Results 141 to 150 of about 328,224 (217)

Elevation of Eosinophil Proportion After Pembrolizumab Increases the Risk of Immune-Related Adverse Events in Patients With Bladder Cancer. [PDF]

Cancer Med
Odagiri K, Tasaki Y, Naiki T, Morikawa T, Iida K, Noda Y, Banno R, Isobe T, Shimizu N, Aoki M, Mimura Y, Sugiyama Y, Nagai T, Etani T, Hamamoto S, Ando R, Kawai N, Furukawa-Hibi Y, Yasui T.   +18 more
europepmc   +1 more source

Probiotic‐Derived Vesicles Rectally Delivered via Thermo‐Gelling Copolymer Promote Mucosal Healing and Reduce Inflammation in Ulcerative Colitis

Advanced Science, EarlyView.
A thermo‐responsive rectal delivery platform integrating probiotic‐derived extracellular vesicles within a hyaluronic acid‐based copolymer enables localized and sustained therapy for ulcerative colitis. The formulation effectively suppresses inflammation, promotes macrophage polarization toward a regenerative phenotype, restores epithelial barrier ...
Ayushi Mairal, Ubaid Tariq, Shreya Mehrotra, Saravanan Matheshwaran, Jan Marsal, Ashok Kumar   +5 more
wiley   +1 more source

Immune-related adverse events in the treatment of Hodgkin lymphoma with immune checkpoint inhibitors. [PDF]

Br J Haematol
Argnani L, Stefoni V, Casadei B, Pelusi C, Preiato VL, Pagotto U, Buganè A, Pellegrini C, Broccoli A, Zinzani PL.   +9 more
europepmc   +1 more source

Membrane‐Active Peptide Protects Against Inflammation by Targeting NLRP3 Activation at the Trans‐Golgi Network

Advanced Science, EarlyView.
The membrane‐active peptide Pep19‐2.5 reduces harmful inflammation by blocking activation of the NLRP3 inflammasome at trans‐Golgi network membranes. By targeting key membrane interactions, Pep19‐2.5 suppresses inflammatory IL‐1β production and alleviates allergic airway inflammation in mice, leading to reduced immune cell infiltration and improved ...
Jonas Engelhardt, Nico Kirsch, Aileen Kerfin, Lars P. Lunding, Dominic Ferber, Hannes Buthmann, Ilka Schreier, Carlotta Bosio, Ann‐Kathrin Dobbelstein, Anna Klawonn, Rebecca C. Coll, Lena Bauernhofer, Sandro Keller, Matthias Geyer, Michael Wegmann, Andra B. Schromm, Günther Weindl   +16 more
wiley   +1 more source

Risk factors for cutaneous immune-related adverse events: a systematic scoping review. [PDF]

Front Immunol
Su Z, Zhang L, Lian X, Wang Y.
europepmc   +1 more source

scTIDE: Deciphering Critical Transitions Through Cell‐Perturbed Manifold Graphs and Optimal Transport Conditional Flow Matching

Advanced Science, EarlyView.
scTIDE identifies single‐cell tipping points by combining manifold‐based graph representations with optimal‐transport conditional flow matching, which preserves intrinsic topology and models distributional dynamics. It supports critical‐transition detection at individual‐cell resolution, prediction of unseen cells, and dimensionality reduction and ...
Jiayuan Zhong, Bowen Niu, Yongbo Yu, Shiyang Nie, Xuerong Gu, Pei Chen, Rui Liu   +6 more
wiley   +1 more source

Risk modifiers of immune-related adverse events in patients with NSCLC undergoing immunotherapy: a retrospective cohort study. [PDF]

J Pharm Health Care Sci
Watanabe T, Suzuki N, Yamauchi M, Iinuma N, Shiozawa M, Arima Y, Sasaki T, Shimodaira H, Kanno SI, Okada K.   +9 more
europepmc   +1 more source

Neuropeptide Y—Graphene Oxide Complexes Inhibit Amygdala NPY‐Receptor Expressing Glutamatergic Pathways and Selectively Remove Aversive Memory In Vivo

Advanced Science, EarlyView.
A graphene oxide nanocarrier presents neuropeptide Y specifically to NPY receptor‐expressing pathways in the amygdala, whose activation selectively suppresses aversive memory formation, without modulating anxiety responses. This circuit‐restricted drug release strategy may impact future design of neuropsychiatric therapies with limited off‐target ...
Elisa Pati, Audrey Franceschi Biagioni, Raffaele Casani, Luis M. Arellano, Tommaso Battisti, Gloria Garcia‐Ortega, Neus Lozano, Alberto Bianco, Kostas Kostarelos, Laura Ballerini, Giada Cellot   +10 more
wiley   +1 more source

Integrated cellular, proteomic and metabolomic profiling of immune-related adverse events in non-small cell lung cancer. [PDF]

Front Immunol
Smith NJ, Gunasegaran B, McLean A, Kohonen-Corish MRJ, Bucca A, Checkley J, Lee JH, Liu JJ, Kao S, Boyer M, Mander K, Brown B, Wang XS, O'Sullivan JF, Fazekas de St Groth B, McGuire HM.   +15 more
europepmc   +1 more source

CA9‐Targeted PET Imaging for Noninvasive Discrimination of Clear Cell Renal Cell Carcinoma and Associated Tumor Biological Features

Advanced Science, EarlyView.
CA9‐targeted PET imaging could be a noninvasive approach to characterize clear cell renal cell carcinoma and associated tumor biology. PET uptake correlates with tumor CA9 expression and is linked to angiogenic activity, immune remodeling, and metabolic reprogramming.
Kailei Chen, Sixuan Cheng, Jian Shi, Ruijie Liu, Yilong Wu, Xin Zheng, Xinlun Song, Yunxuan Zhang, Lei Liu, Zhihao Wei, Qi Wang, Xinwei Li, Zirui Dong, Yuenan Liu, Hongmei Yang, Xiaoli Lan, Chunxia Qin, Dawei Jiang, Keshan Wang, Xiaoping Zhang   +19 more
wiley   +1 more source