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DIFFERENTIAL DIAGNOSIS IN AUTOIMMUNE MYOPATHIES: A CASE OF IMMUNE-MEDIATED NECROTIZING MYOPATHY (IMNM) AND ITS CLINICAL CHALLENGES

John J. Rossi, Marina Machado, Gabrieli Kaori Alves Ishimatsu, Hélida Monteiro de Andrade, Meline Angélica Cunha Rotter Ferreira, Isabel Cristina Hilgert Genz, Larissa Felcar Hill, Anna Hermínia Castro Gomes de Amorim, Luiz Eduardo de Paula, Cecília Resende Brunow Bazzo, Neide Tomimura Costa, Priscila Beatriz de Souza Medeiros   +11 more
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Immune-mediated necrotizing myopathy: clinical features and pathogenesis

Nature Reviews Rheumatology, 2020
Immune-mediated necrotizing myopathy (IMNM) is a group of inflammatory myopathies that was distinguished from polymyositis in 2004. Most IMNMs are associated with anti-signal recognition particle (anti-SRP) or anti-3-hydroxy-3-methylglutaryl-coA reductase (anti-HMGCR) myositis-specific autoantibodies, although ~20% of patients with IMNM remain ...
Yves Allenbach, Olivier Benveniste, Werner Stenzel   +2 more
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Immune Mediated Necrotizing Myopathy

Brain and nerve = Shinkei kenkyu no shinpo
A 70-year-old male with a two-year history of weakness and dysphagia was diagnosed with immune-mediated necrotizing myopathy (IMNM) (Figure 1) confirmed by biopsy and SRP autoantibody positivity.
Stephen Soloway
semanticscholar   +5 more sources

Management of immune‐mediated necrotizing myopathy

Muscle & Nerve
The immune‐mediated necrotizing myopathies (IMNM) are autoimmune myositides clinically characterized by proximal predominant weakness and elevated creatine kinase (CK).
Joome Suh, Anthony A. Amato
semanticscholar   +3 more sources

Immune-mediated necrotizing myopathy (IMNM): A myopathological challenge

Autoimmunity Reviews, 2022
This review is focused on the myopathological spectrum of immune mediated necrotizing myopathies (IMNMs) and its differentiation with other, potentially mimicking, inflammatory and non-inflammatory myopathies. IMNMs are a subgroup of idiopathic inflammatory myopathies (IIMs) characterized by severe clinical presentation with rapidly progressive ...
Merlonghi G., Antonini G., Garibaldi M.
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Immune-mediated necrotizing myopathy

Zeitschrift für Rheumatologie, 2016
Immune-mediated necrotizing myopathy (IMNM) is a newly identified subgroup of idiopathic inflammatory myopathies. It is defined as a rare and severe disease, with symmetrical and proximal muscle weakness and a characteristic histology. An autoimmune aspect of IMNM is suggested by its association with autoantibodies directed against signal recognition ...
C, Bergua, H, Chiavelli, J P, Simon, O, Boyer, F, Jouen, W, Stenzel, J, Martinet   +6 more
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Granulomatous myopathy co-existent immune-mediated necrotizing myopathy: A case report

Clinical Neurology and Neurosurgery, 2023
Granulomatous myopathy (GM) is a rare disease characterized by non-caseating inflammation of the skeletal muscle, with sarcoidosis as a common cause. Here, we report a case of GM co-existent immune-mediated necrotizing myopathy (IMNM) in which an anti-signal recognition particle (SRP) antibody was positive and a muscle biopsy showed a non-caseating ...
Chunli, Yin, Shimin, Yin, Danfeng, Zheng, Ling, Huang, Qiuzhen, Fu   +4 more
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Immune‐mediated necrotizing myopathy associated with statins

Muscle & Nerve, 2009
Abstract We report patients from two neuromuscular centers who were evaluated between the years 2000 and 2008 and met the following criteria: (1) proximal muscle weakness occurring during or after treatment with statins; (2) elevated serum creatine kinase (CK); (3) persistence of weakness and elevated CK despite discontinuation of the
Phyllis, Grable-Esposito, Hans D, Katzberg, Steven A, Greenberg, Jayashri, Srinivasan, Jonathan, Katz, Anthony A, Amato   +5 more
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HLA-DRB1 alleles in immune-mediated necrotizing myopathy

Neurology, 2016
Immune-mediated necrotizing myopathy (IMNM), also known as necrotizing autoimmune myopathy, is a histologic entity characterized by marked necrosis in the absence of prominent lymphocytes.1 Risk factors or triggers for IMNM include statin treatment, cancer, and connective tissue disease (CTD).1,2 Although autoantibodies against signal recognition ...
Yuko, Ohnuki, Shigeaki, Suzuki, Takashi, Shiina, Akinori, Uruha, Yurika, Watanabe, Shingo, Suzuki, Shunichiro, Izumi, Jin, Nakahara, Kohei, Hamanaka, Kazuko, Takayama, Norihiro, Suzuki, Ichizo, Nishino   +11 more
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[Immune-Mediated Necrotizing Myopathy(IMNM)].

Brain and nerve = Shinkei kenkyu no shinpo, 2021
Immune-mediated necrotizing myopathy (IMNM) has recently been classified from polymyositis, and it clinically shows subacute progressive proximal dominant muscle weakness. Laboratory examinations show a great increase in serum creatine kinase and prominent necrotic muscle fibers without any pathological invasion of inflammatory cells.
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