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Immune-mediated necrotizing myopathy: clinical features and pathogenesis
Nature Reviews Rheumatology, 2020Immune-mediated necrotizing myopathy (IMNM) is a group of inflammatory myopathies that was distinguished from polymyositis in 2004. Most IMNMs are associated with anti-signal recognition particle (anti-SRP) or anti-3-hydroxy-3-methylglutaryl-coA reductase (anti-HMGCR) myositis-specific autoantibodies, although ~20% of patients with IMNM remain ...
Allenbach, Yves +3 more
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Management of immune‐mediated necrotizing myopathy
Muscle & NerveAbstractThe immune‐mediated necrotizing myopathies (IMNM) are autoimmune myositides clinically characterized by proximal predominant weakness and elevated creatine kinase (CK). They may be associated with autoantibodies (anti‐HMGCR, anti‐SRP), triggered by statin use (e.g., anti‐HMGCR myopathy), associated with cancer, or may be idiopathic ...
Joome, Suh, Anthony A, Amato
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[Immune-Mediated Necrotizing Myopathy(IMNM)].
Brain and nerve = Shinkei kenkyu no shinpo, 2021Immune-mediated necrotizing myopathy (IMNM) has recently been classified from polymyositis, and it clinically shows subacute progressive proximal dominant muscle weakness. Laboratory examinations show a great increase in serum creatine kinase and prominent necrotic muscle fibers without any pathological invasion of inflammatory cells.
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Immune-Mediated Necrotizing Myopathies: Current Landscape
Current Neurology and Neuroscience ReportsImmune-mediated necrotizing myopathy (IMNM), characterized by acute or subacute onset, severe weakness, and elevated creatine kinase levels, poses diagnostic and therapeutic challenges. This article provides a succinct overview of IMNM, including clinical features, diagnostic strategies, and treatment approaches.Recent insights highlight the different ...
Christoforos, Koumas +1 more
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HLA-DRB1 alleles in immune-mediated necrotizing myopathy
Neurology, 2016Immune-mediated necrotizing myopathy (IMNM), also known as necrotizing autoimmune myopathy, is a histologic entity characterized by marked necrosis in the absence of prominent lymphocytes.1 Risk factors or triggers for IMNM include statin treatment, cancer, and connective tissue disease (CTD).1,2 Although autoantibodies against signal recognition ...
Yuko, Ohnuki +11 more
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Updates in the Management of Immune-Mediated Necrotizing Myopathy
Rheumatic Disease Clinics of North AmericaWhile the treatment landscape of immune-mediated necrotizing myopathy continues to advance, current approaches still rely heavily on expert consensus, given a lack of robust clinical trial data. A deeper understanding of immunopathogenesis remains essential for more effective treatments.
Suur, Biliciler, Eleni, Tiniakou
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Immune-Mediated Necrotizing Myopathy: Update on Diagnosis and Management
Current Rheumatology Reports, 2015The idiopathic inflammatory myopathies (IIMs) comprise a group of autoimmune disorders that target skeletal muscle. They are characterized by typical laboratory and clinical features including muscle weakness, elevated muscle enzymes, characteristic histopathology of muscle biopsies, as well as electromyography abnormalities.
Pari, Basharat, Lisa, Christopher-Stine
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Immune-Mediated Necrotizing Myopathy (IMNM)
2019Immune-mediated necrotizing myopathy (IMNM) is a distinct subset of the idiopathic inflammatory myopathies, characterized by proximal muscle weakness and muscle atrophy, markedly elevated CK levels, and myocyte necrosis with minimal inflammatory infiltrate on muscle biopsy.
Brittany Adler, Lisa Christopher-Stine
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Journal of Clinical Neuromuscular Disease, 2008
ABSTRACT Objective: To describe the clinical course and steroid responsiveness of a patient with subacute proximal symmetric weakness, very high serum creatine kinase activity, and myopathic pattern with fibrillations in the electromyogram, whose muscle biopsy showed necrotizing myopathy, with practically no ...
Menachem, Sadeh, Ron, Dabby
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ABSTRACT Objective: To describe the clinical course and steroid responsiveness of a patient with subacute proximal symmetric weakness, very high serum creatine kinase activity, and myopathic pattern with fibrillations in the electromyogram, whose muscle biopsy showed necrotizing myopathy, with practically no ...
Menachem, Sadeh, Ron, Dabby
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Statins and immune-mediated necrotizing myopathy: Variability in the risk
TherapiesImmune-mediated necrotizing myopathy (IMNM) is a form of statin myopathy characterized by the presence of antibodies against 3-hydroxy-3-methylglutaryl-coenzyme A reductase (anti HMGCR).The aim of this study was to investigate the relationship between the different statins and the risk of IMNM.A two-time approach was used.
Thierry Trenque +5 more
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