Results 1 to 10 of about 1,232 (144)

Integrative Transcriptomic and Target Metabolite Analysis as a New Tool for Designing Metabolic Engineering in Yeast [PDF]

Biomolecules
Precision fermentation processes, especially when using edited microorganisms, demand accuracy in the bioengineering process to maximize the desired outcome and to avoid adverse effects.
Alejandro Lopez-Barbera, Nerea Abasolo, Helena Torrell, Nuria Canela, Salvador Fernández-Arroyo   +4 more
doaj   +3 more sources

Antimicrobial Potential of Hydroxymethylglutaryl-Coa Reductases Inhibitors

The 1st International Electronic Conference on Clinical Medicine, 2021
This study proposes the contemplation of an ecumenical scenario on the antimicrobial potential of statins, based on a scientific narrative review, providing subsidies for research and possibilities in the face of this public health problem.
Hélida Maravilha Dantas e Sousa Almeida, Sávio Benvindo Ferreira, Igor de Sousa Oliveira   +2 more
core   +2 more sources

Diagnosis of Statin-Induced Necrotizing Myopathy: Contribution of Anti-HMGCR Antibodies

Acta Médica Portuguesa, 2022
Over the last few years, several cases of statin-induced necrotizing myopathy have been described. This myopathy is characterized by the necrosis of muscle fibers and the presence of anti-3-hydroxy-3-methylglutaryl-coenzyme A reductase (anti-HMGCR ...
Cláudia Fidalgo, Alice Mendes, Rosário Cunha, Fernando Rodrigues   +3 more
doaj   +1 more source

Statins: a tale of two pathways—cardiovascular savior, renal ineffectual [PDF]

Precision and Future Medicine
Statins are effective in improving outcomes in the general population. However, in patients with chronic kidney disease (CKD), clinical outcomes and therapeutic approaches require careful interpretation from multiple perspectives.
Jihyun Yang
doaj   +1 more source

Peroxisome Proliferator-Activated Receptor Alpha Target Genes [PDF]

, 2010
The peroxisome proliferator-activated receptor alpha (PPARα) is a ligand-activated transcription factor involved in the regulation of a variety of processes, ranging from inflammation and immunity to nutrient metabolism and energy homeostasis.
Rakhshandehroo, M., Rakhshandehroo, Maryam, Knoch, Bianca, Kersten, A.H., Müller, Michael, Bianca Knoch, Maryam Rakhshandehroo, Sander Kersten, Michael Müller, Knoch, B., Kersten, Sander, Müller, M.R.   +11 more
core   +1 more source

Water-Soluble Fish Protein Intake Led to Lower Serum and Liver Cholesterol Concentrations in Obese Zucker fa/fa Rats

Marine Drugs, 2018
Proteins from different fish species and different raw materials such as fish fillets and by-products have shown promising cardioprotective effects in rodents and humans, including effects on cholesterol metabolism. Blue whiting is used mainly to produce
Aslaug Drotningsvik, Linn Anja Vikøren, Svein Are Mjøs, Åge Oterhals, Daniela Pampanin, Ola Flesland, Oddrun Anita Gudbrandsen   +6 more
doaj   +1 more source

A UK multicentre audit of the management of patients with primary hypercholesterolaemia or mixed dyslipidaemia with bempedoic acid against published lipid-lowering treatment targets

Drugs in Context
Background: Bempedoic acid, an adenosine triphosphate citrate lyase inhibitor, was introduced to UK practice via a pre-reimbursement access scheme for adults with primary hypercholesterolaemia or mixed dyslipidaemia who are at high risk of cardiovascular
Sudarshan Ramachandran, Amro Maarouf, Karen Mitchell, Tony Avades, Peter Smith, Lee Boulton, Jennifer Kelly, Nitasha Vekaria, Elizabeth Hughes   +8 more
doaj   +1 more source

Uncovering Coenzyme Q10‐Related Genetic Determinants of Statin‐Associated Muscle Symptoms: Evidence from the UK Biobank and the All of Us Research Program

Clinical Pharmacology &Therapeutics, EarlyView.
Statin‐associated muscle symptoms (SAMS) are frequent adverse effects of statin therapy and have been hypothesized to result from impaired coenzyme Q10 (CoQ10) biosynthesis. Although genetic determinants of CoQ10 levels have been reported, genome‐wide association studies (GWASs) conducted specifically in statin users are lacking. Moreover, direct CoQ10
Da Hoon Lee, Yoon‐A Park, Yubin Song, Ji‐Min Han, Kyung Hee Choi, Myeong Gyu Kim, Hye Sun Gwak   +6 more
wiley   +1 more source

A compendium of extracellular vesicle biogenesis inhibitors: From bench to bedside

Interdisciplinary Medicine, EarlyView.
This review explores a decade of research on extracellular vesicles (EVs), detailing their biogenesis and roles in health and disease. It emphasizes EVs' relevance for potential medical applications covering various conditions such as cancer, neurodegeneration, inflammation, and infectious diseases, bridging experimental findings with clinical ...
Stefano Vecchione, Ana Talamillo, Juan M. Falcón‐Pérez   +2 more
wiley   +1 more source

Melatonin Promotes Improvement in Serum Lipid Levels and Liver Histopathology in Hyperlipidemic Rats

Lipids, EarlyView.
ABSTRACT Hyperlipidemia or dyslipidemia is the term used for the increase in lipid levels in blood plasma, usually occurring due to a high‐fat diet associated with a sedentary lifestyle. The increase in lipid levels can cause fatty infiltration in the liver known as hepatic steatosis, which can lead to inflammation, fibrosis, and necrosis consecutively.
Ana Cláudia Carvalho de Sousa, Jaiurte Gomes Martins da Silva, Érique Ricardo Alves, Laís Caroline da Silva Santos, Bruno José do Nascimento, Marcelle Mariana Sales de França, Vanessa Bischoff Medina, Ismaela Maria Ferreira de Melo, Álvaro Aguiar Coelho Teixeira, Valéria Wanderley Teixeira   +9 more
wiley   +1 more source