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Integrative Transcriptomic and Target Metabolite Analysis as a New Tool for Designing Metabolic Engineering in Yeast [PDF]
BiomoleculesPrecision fermentation processes, especially when using edited microorganisms, demand accuracy in the bioengineering process to maximize the desired outcome and to avoid adverse effects.
Alejandro Lopez-Barbera +4 more
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Diagnosis of Statin-Induced Necrotizing Myopathy: Contribution of Anti-HMGCR Antibodies
Acta Médica Portuguesa, 2022 Over the last few years, several cases of statin-induced necrotizing myopathy have been described. This myopathy is characterized by the necrosis of muscle fibers and the presence of anti-3-hydroxy-3-methylglutaryl-coenzyme A reductase (anti-HMGCR ...
Cláudia Fidalgo +3 more
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A hydroxymethylglutaryl-CoA reductase inhibitor synthesized by yeasts [PDF]
FEMS Microbiology Letters, 1995 Screening of different yeast species showed that they are able to synthesize hydroxymethylglutaryl-CoA (HMGCoA) reductase inhibitors. Crude methanol extracts and the purified inhibitors from Pichia labacensis and Candida cariosilignicola were tested for their biological activity on the solubilized microsomal HMGCoA reductase from Chinese hamster ovary ...
N, Gunde-Cimerman +2 more
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Statins: a tale of two pathways—cardiovascular savior, renal ineffectual [PDF]
Precision and Future MedicineStatins are effective in improving outcomes in the general population. However, in patients with chronic kidney disease (CKD), clinical outcomes and therapeutic approaches require careful interpretation from multiple perspectives.
Jihyun Yang
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Marine Drugs, 2018 Proteins from different fish species and different raw materials such as fish fillets and by-products have shown promising cardioprotective effects in rodents and humans, including effects on cholesterol metabolism. Blue whiting is used mainly to produce
Aslaug Drotningsvik +6 more
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Regulation of hydroxymethylglutaryl-CoA reductase in rat leukocytes
Journal of Lipid Research, 1977 Methods were developed for the assay of hydroxymethylglutaryl-CoA reductase (NADPH) activity in microsomes from rat leukocytes. The activity in freshly isolated leukocytes is low compared to rat liver but can be assayed reliably. The patterns of response of leukocyte reductase in the assay to variation in substrate concentration, protein concentration,
N L Young, V W Rodwell
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Drugs in ContextBackground: Bempedoic acid, an adenosine triphosphate citrate lyase inhibitor, was introduced to UK practice via a pre-reimbursement access scheme for adults with primary hypercholesterolaemia or mixed dyslipidaemia who are at high risk of cardiovascular
Sudarshan Ramachandran +8 more
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Tomato hydroxymethylglutaryl-CoA reductase is required early in fruit development but not during ripening. [PDF]
The Plant Cell, 1989 The activity of 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGR) and the level of its mRNA have been determined at various stages of tomato fruit development. The HMGR reaction makes mevalonate, a necessary component in the synthesis of all isoprene containing compounds, such as sterols and carotenoids.
J O, Narita, W, Gruissem
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Chinese Journal of Contemporary Neurology and Neurosurgery, 2016 Anti-3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR) antibody is a newly recognized autoantibody, which is associated with the use of statins and is considered as an immunological marker of necrotizing autoimmune myopathy (NAM).
Jing-jing LUO +5 more
doaj
Crystal Structure of a Statin Bound to a Class II Hydroxymethylglutaryl-CoA Reductase
Journal of Biological Chemistry, 2003 Hydroxymethylglutaryl-CoA (HMG-CoA) reductase is the primary target in the current clinical treatment of hypercholesterolemias with specific inhibitors of the "statin" family. Statins are excellent inhibitors of the class I (human) enzyme but relatively poor inhibitors of the class II enzymes of important bacterial pathogens.
Tabernero, Lydia; id_orcid 0000-0001-8867-455X +2 more
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