Results 161 to 170 of about 12,890,416 (254)

CART-immune-related adverse events after BCMA CAR-T therapy. [PDF]

Mol Ther Oncol
Paruzzo L, Ho M, Noll JH, Garfall AL, Cohen AD, Fraietta JA, Ruella M.   +6 more
europepmc   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Hematological ratios, immune-related adverse events and mortality in patients treated with immune checkpoint inhibitors

BACKGROUND: Although immune checkpoint inhibitors improve survival in patients with malignancies, a substantial number of patients treated with these agents experience immune-related adverse events.
Regenerative Medicine and Stem Cells, Epi Infectieziekten, Haitjema, Saskia, Hulsbergen-Veelken, Cornelia, Verhaar, Marianne C, CDL Cluster Speciële Diagnostiek, MS Nefrologie, Kaasjager, Karin A H, Khairoun, Meriem, Nefro Vasculaire Geneeskunde, CDL Upod, MS CGO, Circulatory Health, Lekkerkerker, Sophie, Herbschleb, Karin H, Ocak, Gurbey, CDL Cluster Onderzoek en Onderwijs   +16 more
core  

The management of rheumatic immune related adverse events. [PDF]

Best Pract Res Clin Rheumatol
Reid P, Singh N, Braaten T, Cappelli LC.
europepmc   +1 more source

UDP‐Glucose‐6‐Dehydrogenase Mediated O‐GlcNAcylation of Tight Junction Protein 1 Suppresses Metastasis in Renal Cell Carcinoma

Advanced Science, EarlyView.
Our research unveiled a regulatory paradigm wherein TRIM25 orchestrates the ubiquitin‐mediated degradation of UGDH. UGDH modulates the protein stability of TJP1 by regulating O‐GlcNAcylation levels, effectively impeding the metastasis of ccRCC. Our insights elevate UGDH to a pivotal biomarker and tumor suppressor, marking the first demonstration that ...
Xiaolin Chen, Yuhang Bao, Tao Liu, Jianhui Qiu, Yuanyuan Ma, Zedan Zhang, Chuandong Wang, Ruiyi Deng, Zheng Song, Tianyi He, Haode Liu, Jingcheng Zhou, Yizhou Wang, Kan Gong   +13 more
wiley   +1 more source

Seasonal variation in immune-related adverse events in advanced cancer patients. [PDF]

Cancer Immunol Immunother
Liang R, Gao B, Nagrial A, Moujaber T, Carlino MS, Ding PN, Gurney H, Wong M, Habib R, Lo SN, McKeown J, da Silva IP.   +11 more
europepmc   +1 more source

Chiral Nanoparticles Suppress Inflammatory Infiltration to Promote Extracellular Matrix Remodeling for Ectopia Lentis Therapy

Advanced Science, EarlyView.
L‐cysteine‐configured chiral polyurethane nanoparticles suppress ocular inflammation and reduce extracellular matrix (ECM) degradation in ectopia lentis by regulating macrophages polarization and inhibiting nuclear factor kappa B signaling pathway. By promoting zonular fiber‐associated protein restoration and tissue repair, this minimally invasive ...
Yinuo Wen, Yan Yang, Haihan Gao, Yan Liu, Xinyue Wang, Linghao Song, Ruohong Li, Ao Miao, Jie Xu, Zhennan Zhao, Dan Li, Shenjie Peng, Linzhao Li, Min Zhang, Yonghang Liu, Liren Wang, Tianhui Chen, Yongxiang Jiang   +17 more
wiley   +1 more source

Recurrence of Vogt-Koyanagi-Harada Disease as Immune-Related Adverse Events Induced by an Immune Checkpoint Inhibitor. [PDF]

Cureus
Fukushima A, Tabuchi H.
europepmc   +1 more source

Integrative Multi‐Omics Analysis Reveals a Mitochondrial–Immune Axis Associated With Neoadjuvant Chemotherapy Response in High‐Grade Serous Ovarian Cancer

Advanced Science, EarlyView.
Integrative multi‐omics analysis delineates a mitochondrial–immune axis governing neoadjuvant chemotherapy response in high‐grade serous ovarian cancer. Immune‐active tumors exhibit enhanced B‐cell infiltration and favorable sensitivity, whereas metabolically rewired tumors display oxidative phosphorylation dependency and resistance.
Wei Jiang, Yi Wang, Xiaohang Lu, Qianlan Yao, Libing Xiang, Xu Cai, Xiaoyu Tu, Shaoxian Tang, Ying Xu, Yufan Cheng, Liming Shen, Huijuan Yang   +11 more
wiley   +1 more source

Immune-related adverse events with cancer clinical benefits: a systematic review and meta-analysis. [PDF]

BMC Cancer
Li Z, Sun Q, Yang X, Ni J, Zhang Y, Wang J, Ding K, Wang G, Yang H, Yu Q, Li Y.   +10 more
europepmc   +1 more source