Results 31 to 40 of about 2,500,076 (170)

Improved migration of tumor ascites lymphocytes to ovarian cancer microenvironment by CXCR2 transduction

OncoImmunology, 2018
Chemokines are essential mediators of cellular trafficking, interactions and tumor development. Though adoptive cell therapy (ACT) has been a tremendous success in the treatment of metastatic melanoma (MM), a major obstacle for successful ACT, is limited
Manja Idorn, Maria Olsen, Hólmfrídur Rósa Halldórsdóttir, Signe Koggersbøl Skadborg, Magnus Pedersen, Claus Høgdall, Estrid Høgdall, Özcan Met, Per thor Straten   +8 more
doaj   +1 more source

Modeling Alzheimer’s disease related phenotypes in the Ts65Dn mouse: impact of age on Aβ, Tau, pTau, NfL, and behavior

Frontiers in Neuroscience, 2023
IntroductionPeople with DS are highly predisposed to Alzheimer’s disease (AD) and demonstrate very similar clinical and pathological features. Ts65Dn mice are widely used and serve as the best-characterized animal model of DS.MethodsWe undertook studies
Cassia Overk, Emma Fiorini, Chiara Babolin, Marija Vukicevic, Catherine Morici, Rime Madani, Valerie Eligert, Marie Kosco-Vilbois, Amanda Roberts, Ann Becker, Andrea Pfeifer, William C. Mobley   +11 more
doaj   +1 more source

U-Shaped Association of Visceral Fat Area With Diabetic Peripheral Neuropathy

Journal of Diabetes Research
Conclusions: A U-shaped association exists between VFA and DPN prevalence in T2DM patients, suggesting clinical relevance of moderate visceral adiposity.
Xianhua Li, Yingxiang Wang, Xiaotong Feng, Lin Mao, Jing Ke, Dong Zhao   +5 more
doaj   +1 more source

Endogenous Expression of the Human CD83 Attenuates EAE Symptoms in Humanized Transgenic Mice and Increases the Activity of Regulatory T Cells

Frontiers in Immunology, 2019
The CD83 is a type I membrane protein and part of the immunoglobulin superfamily of receptors. CD83 is involved in the regulation of antigen presentation and dendritic cell dependent allogeneic T cell proliferation.
Elisabeth Zinser, Ronald Naumann, Andreas B. Wild, Julia Michalski, Andrea Deinzer, Lena Stich, Christine Kuhnt, Alexander Steinkasserer, Ilka Knippertz   +8 more
doaj   +1 more source

A Prediction Model for Sight-Threatening Diabetic Retinopathy Based on Plasma Adipokines among Patients with Mild Diabetic Retinopathy

Journal of Diabetes Research, 2023
Background. Accumulating evidence has suggested a link between adipokines and diabetic retinopathy (DR). This study is aimed at investigating the risk factors for sight-threatening DR (STDR) and establishing a prognostic model for predicting STDR among a
Yaxin An, Bin Cao, Kun Li, Yongsong Xu, Wenying Zhao, Dong Zhao, Jing Ke   +6 more
doaj   +1 more source

Therapeutic potential of T-cell receptor targeting the HLA-A*11:01-restricted KRASG12V neoantigen without cross-recognition of the self-antigen RAB7B in solid tumors

Journal for ImmunoTherapy of Cancer
Background Public neoantigens, including KRAS, TP53, and PIK3CA mutations, which are shared across various tumor types, have demonstrated significant immunogenicity and offer great promise for cancer immunotherapy.
Wang Wang, Jingjing Huang, Yanan Hao, Lin Zou, Xiaxia Han, Tong Chen, Meiying Shen, Bozhi Wang, Luo Li, Siyin Chen, Shengchun Liu, Xiaojian Han, Aishun Jin   +12 more
doaj   +1 more source

CD83 expression characterizes precursor exhausted T cell population

Communications Biology, 2023
CD83, a member of the immunoglobulin superfamily, is a novel marker to discriminate precursor exhausted T cells from terminally exhausted and bystander tumor-infiltrating T-lymphocytes.
Zhiwen Wu, Toshiaki Yoshikawa, Satoshi Inoue, Yusuke Ito, Hitomi Kasuya, Takahiro Nakashima, Haosong Zhang, Saki Kotaka, Waki Hosoda, Shiro Suzuki, Yuki Kagoya   +10 more
doaj   +1 more source

Immunization Update IV

Advances in Pediatrics, 2009
With all the new vaccines and strategies for prevention, the most important challenge that one continues to talk about globally and at home is the one presented by ongoing transmission of diseases for which excellent vaccines already exist. As pediatricians, this presents a constant reminder to keep the conversation about the importance of vaccine ...
Department of Pediatrics, University of Florida, Pediatric Infectious Diseases, Immunology West 8th Street, LRC 3rd Floor, L-13 Jacksonville, FL 32209, USA ( host institution ), Mirza, Ayesha, Rathore, Mobeen H.   +3 more
openaire   +9 more sources

Immune Logics ain't that Immune

Logic and Logical Philosophy, 2022
Da Ré and Szmuc argue that while there is a symmetry between ‘infectious’ and ‘immune’ logics, this symmetry fails w.r.t. extending an algebra with an immune or an infectious element. In this paper, I show that the symmetry also fails w.r.t. defining a new logical operation from a given set of primitive (Boolean) operations.
openaire   +2 more sources

Subsets of mononuclear phagocytes are enriched in the inflamed colons of patients with IBD

BMC Immunology, 2019
Background Myeloid cells, especially mononuclear phagocytes, which include monocytes, macrophages and dendritic cells (DC), play vital roles in innate immunity, and in the initiation and maintenance of adaptive immunity.
Hong Liu, Suryasarathi Dasgupta, Yu Fu, Brandi Bailey, Christian Roy, Eric Lightcap, Benjamin Faustin   +6 more
doaj   +1 more source