Results 61 to 70 of about 3,611,485 (197)

Activation of transforming growth factor beta by malaria parasite-derived metalloproteinases and a thrombospondin-like molecule [PDF]

, 2003
Much of the pathology of malaria is mediated by inflammatory cytokines (such as interleukin 12, interferon gamma, and tumor necrosis factor alpha), which are part of the immune response that kills the parasite.
Riley, Eleanor M, Sultan, Ali A, J. Brian de Souza, de Souza, J Brian, Eleanor M. Riley, Corran, Patrick H, Patrick H. Corran, Omer, Fakhreldin M, Riley, EM, Sultan, AA, Corran, PH, Ali A. Sultan, Omer, FM, de Souza, JB, Fakhreldin M. Omer   +14 more
core   +1 more source

The innate immune response to HSV-1: glycoprotein mediated activation of dendritic cells [PDF]

, 2009
Herpes Simplex Virus (HSV) – 1 also known as Human Herpes Virus (HHV) – 1 is a common infectious agent of humans which can cause a wide variety of clinical outcomes, ranging from mild mucocutaneous lesions to long term morbidity and possible mortality.
Reske, A., Reske, A
core  

Ethane-β-Sultam Modifies the Activation of the Innate Immune System Induced by Intermittent Ethanol Administration in Female Adolescent Rats [PDF]

, 2014
Intermittent ethanol abuse or ‘binge drinking’ during adolescence induces neuronal damage, which may be associated with cognitive dysfunction. To investigate the neurochemical processes involved, rats were administered either 1 g/kg or 2 g/kg ethanol in ...
Colivicchi Ma, Stefanini C, Hemmings, K., Colivicchi, M.A., Stefanini, C., Della Corte, L., Dexter, D T, De Witte, P, Colivicchi, Stefanini C, Nayak, K., de Witte, Philippe, Pitard, A., Page, M.I., Corte, Della, Pittard, A., Lallemand, f, Ward, Roberta, Ward, Roberta J., Hemmings, Karl, Hemming, Karl, Lallemand, Frederic, Page, Michael I., Dexter, D. T., Dexter, David T., Page, Michael, Nayak, K, Corte, Laura Della   +25 more
core   +1 more source

Evaluation of LIGHT-derived peptides to disrupt the HVEM/LIGHT immune checkpoint

Scientific Reports
Immune checkpoints are critical regulators of immune homeostasis and have become prominent targets in the treatment of various malignancies and autoimmune disorders. While monoclonal antibodies currently dominate checkpoint-targeted therapies, there is a
Piotr Ciura, Simon Gumpelmair, Sylwia Rodziewicz-Motowidło, Peter Steinberger, Marta Spodzieja, Adam K. Sieradzan   +5 more
doaj   +1 more source

Inflammation, iron and vitamin D metabolism in different cardiomyopathy aetiologies

Pteridines, 2020
Immune activation coincides with disturbances in iron and vitamin D metabolism in patients with cardiomyopathy. In this study, we investigated whether there are differences regarding immune activation, iron and vitamin D metabolism between the different ...
Lanser Lukas, Nemati Nada, Seifert Markus, Fuchs Dietmar, Weiss Günter, Pölzl Gerhard, Kurz Katharina   +6 more
doaj   +1 more source

Serum Neopterin Levels and the Clinical Presentation of COVID-19

Pteridines, 2020
In Coronavirus disease 2019 (COVID-19), it is important to evaluate disease activity and investigate possible biomarkers. Therefore, in this study, we investigated the relationship between disease activity and serum levels of possible immune activation ...
Koç Deniz Öğütmen, Sipahi Hande, Sürmeli Cemile Dilşah, Çalık Mustafa, Bireroğlu Nilgün, Öksüz Sıla, Baydar Terken, Şahin Gönül   +7 more
doaj   +1 more source

Cullin-5 deficiency promotes chimeric antigen receptor T cell effector functions potentially via the modulation of JAK/STAT signaling pathway

Nature Communications
Chimeric antigen receptor (CAR) T cell is a promising therapy for cancer, but factors that enhance the efficacy of CAR T cell remain elusive. Here we perform a genome-wide CRISPR screening to probe genes that regulate the proliferation and survival of ...
Yoshitaka Adachi, Seitaro Terakura, Masahide Osaki, Yusuke Okuno, Yoshitaka Sato, Ken Sagou, Yuki Takeuchi, Hirofumi Yokota, Kanae Imai, Peter Steinberger, Judith Leitner, Ryo Hanajiri, Makoto Murata, Hitoshi Kiyoi   +13 more
doaj   +1 more source

Suppression of adaptive immunity to heterologous antigens during Plasmodium infection through hemozoin-induced failure of dendritic cell function [PDF]

, 2005
Background: Dendritic cells (DCs) are central to the initiation and regulation of the adaptive immune response during infection. Modulation of DC function may therefore allow evasion of the immune system by pathogens. Significant depression of the host'
Owain R Millington, R Phillips, Di Lorenzo, Caterina, Phillips, R. Stephen, Millington, Owain R., Paul Garside, Brewer, James M., Caterina Di Lorenzo, Garside, Paul, James M Brewer, Brewer James M, Phillips R, Millington Owain R, Garside Paul, Di Lorenzo Caterina   +14 more
core   +1 more source

Peptide-based inhibitors targeting the PD-1/PD-L1 axis: potential immunotherapeutics for cancer

Translational Oncology
The PD-1/PD-L1 complex belongs to the group of inhibitory immune checkpoints and plays a critical role in immune regulation. The PD-1/PD-L1 axis is also responsible for immune evasion of cancer cells, and this complex is one of the main targets of ...
Magdalena Bojko, Katarzyna Węgrzyn, Emilia Sikorska, Piotr Ciura, Claire Battin, Peter Steinberger, Katarzyna Magiera-Mularz, Grzegorz Dubin, Adam Kulesza, Adam K. Sieradzan, Marta Spodzieja, Sylwia Rodziewicz-Motowidło   +11 more
doaj   +1 more source

Self‐Assembling Glycopeptide Conjugate as a Versatile Platform for Mimicking Complex Polysaccharides

Advanced Science, 2020
Polysaccharides are a class of carbohydrates that play pivotal roles in living systems such as being chemical messengers in many vital biological pathways.
Hanxuan Wang, Zhichao Liu, Chuanjing An, Haoting Li, Fanlei Hu, Suwei Dong   +5 more
doaj   +1 more source