A high-throughput two-cell assay for interrogating inhibitory signaling pathways in T cells
Life Science AllianceThis work describes a high-throughput cellular assay specifically designed to study the understudied inhibitory signalling pathway in T cells. The recent success of immunotherapies relying on manipulation of T-cell activation highlights the value of ...
Sumana Sharma +9 more
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Age-related impairment of human T lymphocytes' activation: specific differences between CD4+ and CD8+ subsets [PDF]
, 2006 The relevance of physiological immune aging is of great interest with respect to determining disorders with pathologic immune function in aging individuals.
Maurer, Konrad +4 more
core
Prenatal activation of toll-like receptors-3 by administration of the viral mimetic poly(I:C) changes synaptic proteins, N-methyl-D-aspartate receptors and neurogenesis markers in offspring [PDF]
, 2012 Background - There is mounting evidence for a neurodevelopmental basis for disorders such as autism and schizophrenia, in which prenatal or early postnatal events may influence brain development and predispose the young to develop these and related ...
Stone, T.W. +5 more
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CXCL13 as a Biomarker of Immune Activation During Early and Chronic HIV Infection
Frontiers in Immunology, 2019 Background: CXCL13 is preferentially secreted by Follicular Helper T cells (TFH) to attract B cells to germinal centers. Plasma levels of CXCL13 have been reported to be elevated during chronic HIV-infection, however there is limited data on such ...
Vikram Mehraj +31 more
doaj +1 more source
Frontiers in Immunology, 2022 Coronavirus disease 2019 (COVID-19) is an infectious disease caused by beta-coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that has rapidly spread across the globe starting from February 2020.
Elisa Pesce +36 more
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THE RELATIONSHIP BETWEEN RESIDUAL VIREMIA AND CHRONIC INFLAMMATION IN PATIENTS ON LONG-TERM ANTIRETROVIRAL THERAPY [PDF]
, 2013 Since the development of combination antiretroviral therapy, morbidity and mortality due to AIDS-related malignancies has declined significantly. In most patients, daily administration of a multidrug antiretroviral regimen is sufficient to suppress ...
Hilldorfer IV, Benedict B.
core
Immune activation and collateral damage in AIDS pathogenesis
Frontiers in Immunology, 2013 In the past decade, evidence has accumulated that HIV-induced chronic immune activation drives progression to AIDS. Studies among different monkey species have shown that the difference between pathological and non-pathological infection is determined by
Frank eMiedema +5 more
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Immune Activation in Alzheimer Disease
Annual Review of ImmunologyAlzheimer disease (AD) is the most common neurodegenerative disease, and with no efficient curative treatment available, its medical, social, and economic burdens are expected to dramatically increase. AD is historically characterized by amyloid β (Aβ) plaques and tau neurofibrillary tangles, but over the last 25 years chronic immune activation has ...
MARY, Arnaud +2 more
openaire +4 more sources
Inactivation of cytidine triphosphate synthase 1 prevents fatal auto-immunity in mice
Nature CommunicationsDe novo synthesis of the pyrimidine, cytidine triphosphate (CTP), is crucial for DNA/RNA metabolism and depends on the CTP synthetases, CTPS1 and −2. Partial CTPS1 deficiency in humans has previously been shown to lead to immunodeficiency, with impaired ...
Claire Soudais +17 more
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Immune-Mediated Inflammation in Vulnerable Atherosclerotic Plaques
Molecules, 2019 Atherosclerosis is a chronic long-lasting vascular disease leading to myocardial infarction and stroke. Vulnerable atherosclerotic (AS) plaques are responsible for these life-threatening clinical endpoints.
Harald Mangge, Gunter Almer
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