Results 31 to 40 of about 3,611,485 (197)

A New Strategy Toward B Cell-Based Cancer Vaccines by Active Immunization With Mimotopes of Immune Checkpoint Inhibitors

Frontiers in Immunology, 2020
Therapeutic monoclonal antibodies (mAbs), targeting tumor antigens, or immune checkpoints, have demonstrated a remarkable anti-tumor effect against various malignancies.
Joshua Tobias, Claire Battin, Annika De Sousa Linhares, Michael Lebens, Karin Baier, Katharina Ambroz, Mirjana Drinić, Sandra Högler, Aleksandra Inic-Kanada, Erika Garner-Spitzer, Matthias Preusser, Lukas Kenner, Lukas Kenner, Michael Kundi, Christoph C. Zielinski, Peter Steinberger, Ursula Wiedermann   +16 more
doaj   +1 more source

Short- and Long-Term Immunological Responses in Chronic HCV/HIV Co-Infected Compared to HCV Mono-Infected Patients after DAA Therapy

Pathogens, 2021
Background: Direct-acting antivirals (DAAs) treatment, although highly efficacious for the treatment of hepatitis C virus (HCV) infection, may not completely reconstitute the HCV-mediated dysregulated immune system, especially in patients co-infected ...
Stefania Farcomeni, Sonia Moretti, Caterina Fimiani, Lucia Fontanelli Sulekova, Fenicia Vescio, Leonardo Sernicola, Maria T. Maggiorella, Anna Lisa Remoli, Orietta Picconi, Luciana Mosca, Rozenn Esvan, Elisa Biliotti, Massimo Ciccozzi, Marco Sgarbanti, Gloria Taliani, Alessandra Borsetti   +15 more
doaj   +1 more source

Opioids exacerbate inflammation in people with well-controlled HIV

Frontiers in Immunology, 2023
IntroductionPeople with HIV (PWH) are known to have underlying inflammation and immune activation despite virologic control. Substance use including opioid dependence is common in this population and is associated with increased morbidity and reduced ...
Christine M. Dang, C. Mindy Nelson, Daniel J. Feaster, Alexander Kizhner, David W. Forrest, Nobuyo Nakamura, Akshay Iyer, Priya P. Ghanta, Dushyantha T. Jayaweera, Allan E. Rodriguez, Rajendra N. Pahwa, Hansel E. Tookes, Suresh Pallikkuth, Savita G. Pahwa   +13 more
doaj   +1 more source

The role of coronin 1 during cell mediated immune responses [PDF]

, 2013
Coronin 1 is one of 7 mammalian isoforms member of the evolutionary conserved WD40-repeat proteins that are involved in a variety of activities such a cell migration and cytokinesis.
Tchang, Vincent Sam Yong
core   +1 more source

Effects of maternal immune activation on offspring neuroimmune function at postnatal day 7

, 2023
Schwarz, Jaclyn M.Neurodevelopment of the offspring can be affected by changes in maternal health, particularly associated with inflammation and systemic immune activation during pregnancy.
Starr, Alexandra
core   +1 more source

Transcriptional reprogramming via signaling domains of CD2, CD28, and 4-1BB

iScience
Summary: Costimulatory signals provided to T cells during antigen encounter have a decisive role in the outcome of immune responses. Here, we used chimeric receptors harboring the extracellular domain of mouse inducible T cell costimulator (mICOS) to ...
Annika De Sousa Linhares, Sumana Sharma, Peter Steinberger, Judith Leitner   +3 more
doaj   +1 more source

High seroprevalence of Leishmania infantum is linked to immune activation in people with HIV: a two-stage cross-sectional study in Bahia, Brazil

Frontiers in Microbiology, 2023
Visceral leishmaniasis is an opportunistic disease in HIV-1 infected individuals, unrecognized as a determining factor for AIDS diagnosis. The growing geographical overlap of HIV-1 and Leishmania infections is an emerging challenge worldwide, as co ...
Laise de Moraes, Laise de Moraes, Luciane Amorim Santos, Luciane Amorim Santos, Luciane Amorim Santos, Liã Bárbara Arruda, Maria da Purificação Pereira da Silva, Márcio de Oliveira Silva, José Adriano Góes Silva, José Adriano Góes Silva, José Adriano Góes Silva, André Ramos, Marcos Bastos dos Santos, Felipe Guimarães Torres, Cibele Orge, Antonio Marcos dos Santos Teixeira, Thiago Santos Vieira, Laura Ramírez, Manuel Soto, Maria Fernanda Rios Grassi, Maria Fernanda Rios Grassi, Isadora Cristina de Siqueira, Dorcas Lamounier Costa, Carlos Henrique Nery Costa, Bruno de Bezerril Andrade, Bruno de Bezerril Andrade, Kevan Akrami, Kevan Akrami, Camila Indiani de Oliveira, Camila Indiani de Oliveira, Camila Indiani de Oliveira, Viviane Sampaio Boaventura, Viviane Sampaio Boaventura, Viviane Sampaio Boaventura, Manoel Barral-Netto, Manoel Barral-Netto, Aldina Barral, Aldina Barral, Anne-Mieke Vandamme, Anne-Mieke Vandamme, Johan Van Weyenbergh, Ricardo Khouri, Ricardo Khouri, Ricardo Khouri   +43 more
doaj   +1 more source

The application of exosomes in the early diagnosis and treatment of osteoarthritis

Frontiers in Pharmacology, 2023
With the increase in human lifespan and the aggravation of global aging, the incidence of osteoarthritis (OA) is increasing annually. To better manage and control the progression of OA, prompt diagnosis and treatment for early-stage OA are important ...
Anjing Chen, Anjing Chen, Yangmengfan Chen, Xiao Rong, Xuanhe You, Diwei Wu, Xinran Zhou, Weinan Zeng, Zongke Zhou, Zongke Zhou   +9 more
doaj   +1 more source

Dietary fatty acids modulate inflammatory cytokine production through activation of MAP kinases [PDF]

, 2007
Polyunsaturated fatty acids (PUFA) have therapeutic effects in inflammatory diseases, however the specific mechanisms by which they exert these effects have not yet been defined.
Braddish, Della
core   +1 more source

Development of a Human Cytomegalovirus (HCMV)-Based Therapeutic Cancer Vaccine Uncovers a Previously Unsuspected Viral Block of MHC Class I Antigen Presentation

Frontiers in Immunology, 2019
Human cytomegalovirus (HCMV) induces a uniquely high frequency of virus-specific effector/memory CD8+ T-cells, a phenomenon termed “memory inflation”.
Mohammed O. Abdelaziz, Sophia Ossmann, Andreas M. Kaufmann, Judith Leitner, Peter Steinberger, Gerald Willimsky, Gerald Willimsky, Gerald Willimsky, Martin J. Raftery, Günther Schönrich   +9 more
doaj   +1 more source