Results 21 to 30 of about 3,611,485 (197)

PD-1 Blockade Promotes Emerging Checkpoint Inhibitors in Enhancing T Cell Responses to Allogeneic Dendritic Cells

Frontiers in Immunology, 2017
Immune checkpoint inhibitors, which target coinhibitory T cell molecules to promote anticancer immune responses, are on the rise to become a new pillar of cancer therapy.
Carmen Stecher, Claire Battin, Judith Leitner, Markus Zettl, Katharina Grabmeier-Pfistershammer, Christoph Höller, Gerhard J. Zlabinger, Peter Steinberger   +7 more
doaj   +1 more source

Neuropilin-1 Acts as a Receptor for Complement Split Products

Frontiers in Immunology, 2019
Complement split products (CSPs), such as the fragments C4d and C3d, which are generated as a consequence of complement regulatory processes, are established markers for disease activity in autoimmunity or antibody-mediated graft rejection.
Claire Battin, Annika De Sousa Linhares, Wolfgang Paster, Wolfgang Paster, David E. Isenman, Markus Wahrmann, Judith Leitner, Gerhard J. Zlabinger, Peter Steinberger, Johannes Hofer   +9 more
doaj   +1 more source

Immune Activation in Sepsis

Critical Care Clinics, 2018
Sepsis is caused by a dysregulated host response to infection. Immune responses determine the characteristics of sepsis. The body's protection against infection involves danger signal surveillance and recognition from nonself, effector functions in response to sensing danger signals, homeostatic regulation, and generation of immunologic memory.
Conway-Morris, Andrew, Wilson, Julie, Shankar-Hari, Manu   +2 more
openaire   +3 more sources

Tumor growth inhibition and immune system activation following treatment with thorium-227 conjugates and PD-1 check-point inhibition in the MC-38 murine model

Frontiers in Medicine, 2022
Targeted thorium-227 conjugates comprise the combination of a monoclonal antibody with specificity for a tumor cell antigen and a 3,2-HOPO chelator enabling complexation of thorium-227 (Th-227).
Axel Berg-Larsen, Anne Mobergslien, Ingrid Moen, Gebregziabher Petros, Alexander Kristian, Kristine Sponheim Gunvaldsen, Véronique Cruciani, Katrine Wickstroem, Roger Malerbakken Bjerke, Jenny Karlsson, Alan Cuthbertson   +10 more
doaj   +1 more source

ACTIVE IMMUNIZATION AGAINST POLIOMYELITIS [PDF]

Journal of Experimental Medicine, 1932
1. A single intracutaneous inoculation with a subinfective dose of the virus of poliomyelitis produces considerable immunity. 2. Virus-serum combinations produce an appreciable immunity, providing just sufficient serum is used to protect the animal from paralysis.
openaire   +4 more sources

Hemophagocytic Lymphohistiocytosis after ChAdOx1 nCoV-19 Coronavirus Vaccination in a Patient with no Known Comorbidities

Indian Journal of Medical Specialities, 2022
Hemophagocytic lymphohistiocytosis (HLH) is an inflammatory condition where there is marked cytopenia and large-scale activation of macrophages and CD8+ cytotoxic T cells.
Nitin Rai, Saumitra Misra, Shashank Prajapati, Shubhajeet Roy, Geeta Yadav   +4 more
doaj   +1 more source

Activation of natural killer cells during microbial infections. [PDF]

, 2011
Natural killer (NK) cells are large granular lymphocytes that express a diverse array of germline encoded inhibitory and activating receptors for MHC Class I and Class I-like molecules, classical co-stimulatory ligands, and cytokines.
Riley, Eleanor M, Eleanor M Riley, Amir eHorowitz, Horowitz, Amir, Stegmann, Kerstin A, Kerstin eStegmann, Amir Horowitz, Eleanor M. Riley, Kerstin A. Stegmann   +8 more
core   +1 more source

Impact of immune activation and inflammation on the susceptibility to HIV infection and disease progression in HIV serodiscordant and seroconcordant couples [PDF]

, 2014
Includes bibliographical references.The biological correlates of protection against HIV infection remain poorly characterized, hindering the development of an effective prevention strategy. Studies of individuals who resist HIV infection or progress more
Jaumdally, Shameem Zaer
core   +1 more source

A Vaccine Construction against COVID-19-Associated Mucormycosis Contrived with Immunoinformatics-Based Scavenging of Potential Mucoralean Epitopes

Vaccines, 2022
Mucormycosis is a group of infections, caused by multiple fungal species, which affect many human organs and is lethal in immunocompromised patients. During the COVID-19 pandemic, the current wave of mucormycosis is a challenge to medical professionals ...
Muhammad Naveed, Urooj Ali, Mohmed Isaqali Karobari, Naveed Ahmed, Roshan Noor Mohamed, Shahabe Saquib Abullais, Mohammed Abdul Kader, Anand Marya, Pietro Messina, Giuseppe Alessandro Scardina   +9 more
doaj   +1 more source

Myosin II Synergizes with F-Actin to Promote DNGR-1-Dependent Cross-Presentation of Dead Cell-Associated Antigens

Cell Reports, 2018
Summary: Conventional type 1 DCs (cDC1s) excel at cross-presentation of dead cell-associated antigens partly because they express DNGR-1, a receptor that recognizes exposed actin filaments on dead cells.
Oliver Schulz, Pavel Hanč, Jan P. Böttcher, Robbert Hoogeboom, Sandra S. Diebold, Pavel Tolar, Caetano Reis e Sousa   +6 more
doaj   +1 more source