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Immune suppression and immune activation in depression [PDF]
Brain, Behavior, and Immunity, 2011 Depression has been characterized as a disorder of both immune suppression and immune activation. Markers of impaired cellular immunity (decreased natural killer cell cytotoxicity) and inflammation (elevated IL-6, TNFα, and CRP) have been associated with depression.
Dwight L Evans
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FcγR requirements and costimulatory capacity of Urelumab, Utomilumab, and Varlilumab
Frontiers in Immunology, 2023 IntroductionTargeting costimulatory receptors of the tumor necrosis factor receptor (TNFR) superfamily with agonistic antibodies is a promising approach in cancer immuno therapy.
Judith Leitner +4 more
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Frontiers in Immunology, 2022 Toll-like receptors (TLRs) are primary pattern recognition receptors (PRRs), which recognize conserved microbial components. They play important roles in innate immunity but also in the initiation of adaptive immune responses.
Katharina Radakovics +7 more
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Nature Communications, 2022 Immunoglobulin M (IgM) is the Ig isotype that serves as the first line of host defence during infection. Here, the authors image the full-length IgM pentamer by cryo-EM, revealing the structure and hinge motion of the antigen binding domains.
Qu Chen +4 more
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Interrogating ligand-receptor interactions using highly sensitive cellular biosensors
Nature Communications, 2023 Interactions of membrane-resident proteins are important targets for therapeutic interventions but most methods to study them are either costly, laborious or fail to reflect the physiologic interaction of membrane resident proteins in trans.
Maximilian A. Funk +10 more
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BTLA inhibition has a dominant role in the cis-complex of BTLA and HVEM
Frontiers in Immunology, 2022 The engagement of the herpesvirus entry mediator (HVEM, TNFRSF14) by the B and T lymphocyte attenuator (BTLA) represents a unique interaction between an activating receptor of the TNFR-superfamily and an inhibitory receptor of the Ig-superfamily.
Claire Battin +5 more
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Microorganisms, 2022 Chlamydia trachomatis (Ct) is the most common cause of genital tract infections as well as preventable blindness worldwide. Pattern recognition receptors such as toll-like receptors (TLRs) represent the initial step in recognizing pathogenic ...
Romana Klasinc +8 more
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Discovery of the first PD-1 ligand encoded by a pathogen
Frontiers in Immunology, 2022 Large double-stranded DNA viruses deploy multiple strategies to subvert host immune defenses. Some of these tactics are mediated by viral gene products acquired by horizontal gene transfer from the corresponding hosts and shaped throughout evolution. The
Pablo Martínez-Vicente +8 more
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Active Immunization Against Poliomyelitis [PDF]
American Journal of Public Health and the Nations Health, 1936 Controlled clinical and experimental studies have shown that convalescent serum is inefficacious in the treatment of preparalytic poliomyelitis. 1 The reason for this can be seen from the pathogenesis of the disease, which indicates that poliomyelitis is an infection of the central nervous system exclusively.
M, Brodie, W H, Park
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Cell Reports, 2018 Summary: B cell responses are regulated by antigen acquisition, processing, and presentation to helper T cells. These functions are thought to depend on contractile activity of non-muscle myosin IIa.
Robbert Hoogeboom +6 more
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