Results 101 to 110 of about 3,195,227 (346)

Multiple Mechanisms of Action of Sulfodyne^®, a Natural Antioxidant, against Pathogenic Effects of SARS-CoV-2 Infection

Antioxidants
Few therapeutic options are available to treat COVID-19. The KEAP1/NRF2 pathway, the major redox-responsive pathway, has emerged as a potential therapeutic target for COVID-19 as it regulates redox homeostasis and inflammation that are altered during ...
Paul-Henri Romeo, Laurine Conquet, Sébastien Messiaen, Quentin Pascal, Stéphanie G. Moreno, Anne Bravard, Jacqueline Bernardino-Sgherri, Nathalie Dereuddre-Bosquet, Xavier Montagutelli, Roger Le Grand, Vanessa Petit, Federica Ferri   +11 more
doaj   +1 more source

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

Gut microbiota diversity is prognostic in metastatic hormone receptor‐positive breast cancer patients receiving chemotherapy and immunotherapy

Molecular Oncology, EarlyView.
In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern, Kristian Holm, Nikolai Kragøe Andresen, Andreas Hagen Røssevold, Corinna Bang, Bjørn Naume, Johannes R. Hov, Jon Amund Kyte   +7 more
wiley   +1 more source

A comprehensive review on potential role of selenium, selenoproteins and selenium nanoparticles in male fertility

Heliyon
Selenium (Se), a component of selenoproteins and selenocompounds in the human body, is crucial for the development of male reproductive organs, DNA synthesis, thyroid hormone, metabolism, and defence against infections and oxidative damage. In the testis,
Shuai Yuan, Ye Zhang, Pei-Yu Dong, Yu-Mei Chen Yan, Jing Liu, Bing-Qiang Zhang, Meng-Meng Chen, Shu-Er Zhang, Xi-Feng Zhang   +8 more
doaj   +1 more source

Identification of Shared Immune Cells and Immune-Related Co-Disease Genes in Chronic Heart Failure and Systemic Lupus Erythematosus Based on Transcriptome Sequencing

Journal of Inflammation Research, 2023
Ziyue Luo,1,* Guifang Lu,2,* Qiang Yang,1 Juncan Ding,1 Tianyu Wang,1 Pengfei Hu3 1Second Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, Zhejiang Province, 310053, People’s Republic of China; 2Department of Rheumatology,
Luo Z, Lu G, Yang Q, Ding J, Wang T, Hu P   +5 more
doaj  

Immune Checkpoint Inhibitor-Induced Limbic Encephalitis during Treatment with Atezolizumab in a Patient with Small-Cell Lung Cancer: A Case Report and Review of the Literature [PDF]

, 2022
Koki Nakashima, Yoshiki Demura, Kosuke Kurokawa, Toshihiro Takeda, Norihiro Jikuya, Masahiro Oi, Toshihiko Tada, Masaya Akai, Tamotsu Ishizuka   +8 more
openalex   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

The diagnostic of PAX1 gene methylation in cervical lesions and its role in the triage of non-16/18 HR-HPV positive

Frontiers in Immunology
ObjectiveThis study aims to systematically evaluate the application value of PAX1 gene methylation detection in cervical lesion screening and its potential advantages in the triage of non-16/18 high-risk human papillomavirus (HR-HPV) positive patients ...
Meng-Meng Chen, Meng-Meng Chen, Bing-Qiang Zhang, Bing-Qiang Zhang, Yan-Song Luan, Guo-Long Sun, Yun-Yuan Zhang, Xiao-Yan Zhou, Xi-Feng Zhang, Feng-Chun Gao, Jun-Mei Yu   +10 more
doaj   +1 more source

In vitro properties of patient serum predict clinical outcome after high dose rate brachytherapy of hepatocellular carcinoma

Molecular Oncology, EarlyView.
Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser, Jan Niklas Schäfer, Shraga Nahum Goldberg, Philipp Maximilian Kazmierczak, Moritz Nikolaus Gröper, Philipp Franz Linden, Elif Öcal, Tanja Burkard, Stefanie Corradini, Najib Ben Khaled, Moritz Wildgruber, Max Seidensticker, Jens Ricke, Matthias Stechele, Marianna Alunni‐Fabbroni   +14 more
wiley   +1 more source

Pathogenicity and host-interacting mechanisms of enterogenic Enterobacter cancerogenus in silkworm

Frontiers in Microbiology
IntroductionEnterobacter cancerogenus (E. cancerogenus) is a facultative anaerobic, gram-negative bacterium that can be utilized for the biological control of pests. However, the molecular mechanisms underlying the pathogenicity of E.
Meng Luo, Linhui Lai, Zailin Wu, Zailin Wu, Zailin Wu, Xiaoli Ren, Xiaoli Ren, Xiaoli Ren, Jiacheng Zhao, Jiacheng Zhao, Jiacheng Zhao, Hongmei Liu, Hongmei Liu, Hongmei Liu, Yaohang Long, Yaohang Long, Yaohang Long   +16 more
doaj   +1 more source