Results 111 to 120 of about 14,522,121 (350)

Global trends in tertiary lymphoid structures: a bibliometric analysis from 2014 to 2023

Frontiers in Immunology
Aim and backgroundTertiary lymphoid structures (TLS) are increasingly recognized for their role in immunity. Despite growing interest, a systematic bibliometric analysis of TLS-related research has been lacking.
Yiwen Bao, Yiwen Bao, Zeming Mo, Shuang Wang, Shuang Wang, Jinhua Long, Honghong Zhang, Honghong Zhang, Yujun Xu, Yujun Xu, Honglian Jiang, Tianbao Qian, Tianbao Qian, Zhu Zeng, Zhu Zeng   +14 more
doaj   +1 more source

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

Molecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez, Pablo Juanes‐Velasco, Marina L. García‐Vaquero, Conrad Droste, Alicia Landeira‐Viñuela, Miguel Alcoceba, Helena Fidalgo‐Gómez, Sara Misiego‐Herrero, Almudena Navarro‐Bailón, Mónica Baile, José M. Bastida, Jose Manuel Sanchez‐Santos, Rafael Góngora, Julia Almeida, Marcos Gonzalez‐Diaz, Alberto Orfao, Javier De Las Rivas, Manuel Fuentes   +17 more
wiley   +1 more source

Mechanisms regulating PD-L1 expression on tumor and immune cells

Journal of Immunotherapy for Cancer, 2019
BackgroundThe PD-1/PD-L1 checkpoint is a central mediator of immunosuppression in the tumor immune microenvironment (TME) and is primarily associated with IFN-g signaling.
Shuming Chen, George A. Crabill, Theresa S. Pritchard, T. McMiller, P. Wei, D. Pardoll, F. Pan, S. Topalian   +7 more
semanticscholar   +1 more source

Expression and DNA methylation of 20S proteasome subunits as prognostic and resistance markers in cancer

Molecular Oncology, EarlyView.
Comprehensive analysis of genomic mutations, gene expression, DNA methylation, and pathway analysis of TCGA data was carried out to define cancer types in which proteasome subunits expression is associated with worse survival. Albeit the effect of specific proteasome subunits on cellular function, the main role of the proteasome is better evaluated ...
Ruba Al‐Abdulla, Simone Venz, Ruslan Al‐Ali, Martin Wendlandt, Mandy Radefeldt, Elke Krüger   +5 more
wiley   +1 more source

Multiple Mechanisms of Action of Sulfodyne^®, a Natural Antioxidant, against Pathogenic Effects of SARS-CoV-2 Infection

Antioxidants
Few therapeutic options are available to treat COVID-19. The KEAP1/NRF2 pathway, the major redox-responsive pathway, has emerged as a potential therapeutic target for COVID-19 as it regulates redox homeostasis and inflammation that are altered during ...
Paul-Henri Romeo, Laurine Conquet, Sébastien Messiaen, Quentin Pascal, Stéphanie G. Moreno, Anne Bravard, Jacqueline Bernardino-Sgherri, Nathalie Dereuddre-Bosquet, Xavier Montagutelli, Roger Le Grand, Vanessa Petit, Federica Ferri   +11 more
doaj   +1 more source

Data‐driven discovery of gene expression markers distinguishing pediatric acute lymphoblastic leukemia subtypes

Molecular Oncology, EarlyView.
This study investigates gene expression differences between two major pediatric acute lymphoblastic leukemia (ALL) subtypes, B‐cell precursor ALL, and T‐cell ALL, using a data‐driven approach consisting of biostatistics and machine learning methods. Following analysis of a discovery dataset, we find a set of 14 expression markers differentiating the ...
Mona Nourbakhsh, Nikola Tom, Anna Schrøder Lassen, Helene Brasch Lind Petersen, Ulrik Kristoffer Stoltze, Karin Wadt, Kjeld Schmiegelow, Matteo Tiberti, Elena Papaleo   +8 more
wiley   +1 more source

ADAPTIVE IMMUNE RESPONSE OF T CELLS IN PERIODONTAL DISEASE

Romanian Journal of Oral Rehabilitation, 2021
Because it is well known that T cells are a heterogeneous population, and a balance between functionally of different T cell subsets is crucial in immune regulation, a series of studies have attempted to associate an impaired balance between each T cell ...
Ancuța Goriuc, Ioana Mârțu, Liliana Foia, Carina Balcoș, Adina Armencia, Ionuț Luchian, Otilia Frăsinariu, Raluca Jipu   +7 more
doaj  

Prognostic value of novel immune-related genomic biomarkers identified in head and neck squamous cell carcinoma [PDF]

, 2020
Yao Yao, Zhongyi Yan, Senlin Lian, Liangnian Wei, Chao Zhou, Dongju Feng, Yuan Zhang, Jianrong Yang, Ming Li, Yun Chen   +9 more
openalex   +1 more source

The role of immune cells and mediators in preeclampsia

Nature Reviews Nephrology, 2023
E. Deer, O. Herrock, N. Campbell, D. Cornelius, S. Fitzgerald, L. Amaral, B. LaMarca   +6 more
semanticscholar   +1 more source

Comprehensive omics‐based classification system in adult patients with B‐cell acute lymphoblastic leukemia

Molecular Oncology, EarlyView.
The COMBAT classification system, developed through multi‐omics integration, stratifies adult patients with B‐cell acute lymphoblastic leukemia(B‐ALL) into three molecular subtypes with distinct surface antigen patterns, immune landscape, methylation patterns, biological pathways and prognosis.
Yang Song, Ting Liu, Qishan Hao, Qiuyun Fang, Xiaoyuan Gong, Yan Li, Zheng Tian, Hui Wei, Min Wang, Jianxiang Wang, Tao Cheng, Yingchang Mi   +11 more
wiley   +1 more source