Results 141 to 150 of about 2,005,391 (219)

Migration of immune cells in tumors and inflammation: molecular mechanisms and therapeutic targets. [PDF]

Signal Transduct Target Ther
Lu Y, Shao D, Xiao Y, Jiang YZ, Shao ZM.
europepmc   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Spectral biophysical cytometry with nanosensors reveals remodelling of immune cells in atherosclerosis. [PDF]

Nat Nanotechnol
Gurdap CO, Aydos D, Andronico LA, Tóth G, Ceker T, Cowgill J, Akbulut Koyuncu IM, Basak N, Mikes J, Klymchenko AS, Pietrocola F, Brodin P, Lanekoff I, Bitirim VC, Sezgin E.   +14 more
europepmc   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Retraction Note: Neuroinflammation is associated with infiltration of T cells in Lewy body disease and α-synuclein transgenic models

Journal of Neuroinflammation
Michiyo Iba, Changyoun Kim, Michelle Sallin, Somin Kwon, Anjali Verma, Cassia Overk, Robert A. Rissman, Ranjan Sen, Jyoti Misra Sen, Eliezer Masliah   +9 more
doaj   +1 more source

Differential Regulation of Granule Release in Platelets and Immune Cells. [PDF]

TH Open
Xia Q, Hu J, Sun H, Zhu Z, Jiang W.
europepmc   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

The impact of effective dose to the immune cells on survival in breast cancer patients. [PDF]

Clin Transl Radiat Oncol
de Boer SA, Spoor DS, Maduro JH, Deseyne PRAJ, Muijs CT, Sijtsema NM, de Vette SPM, van Dijk LV, Schuit E, Langendijk JA, Crijns APG.   +10 more
europepmc   +1 more source

Yeast Gcn2 retains activity following humanization of its auto‐phosphorylation region

FEBS Open Bio, EarlyView.
Using Saccharomyces cerevisiae as a model to study Gcn2 activation and regulation is limited by the lack of antibodies detecting phosphorylated Gcn2. To overcome this, we engineered Gcn2‐HsC, a yeast Gcn2 variant recognizable by commercial anti‐human phospho‐GCN2 antibodies.
Reuben A. Anderson, Anja H. Schiemann, Evelyn Sattlegger   +2 more
wiley   +1 more source

Intercellular mechanical communication drives the directional migration of Jurkat T immune cells. [PDF]

Mechanobiol Med
Liu H, Zhang Q, Guo J, Chen L, Li B, Ouyang M, Deng L.   +6 more
europepmc   +1 more source