Results 181 to 190 of about 3,195,227 (346)

Functional roles of immune cells in osteoporosis. [PDF]

Front Immunol
Qi Z, Luo J, Xiao Z, Yang D.
europepmc   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Resveratrol for Cancer Treatment: Effects on Metabolism and Immune Cells. [PDF]

Biomolecules
Bao R, Wang T, Jiang W.
europepmc   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Special Issue "Mesenchymal Stromal and Immune Cells' Involvement in Human Diseases and Their Treatment". [PDF]

Int J Mol Sci
Jerkic M.
europepmc   +1 more source

The causal role between circulating immune cells and diabetic nephropathy: a bidirectional Mendelian randomization with mediating insights [PDF]

Ning Shen, Shangwei Lu, Zhijuan Kong, Ying Gao, Jinxiu Hu, Shuxuan Si, Junlin Wang, Jie Li, Wei Han, Rong Wang, Zhimei Lv   +10 more
openalex   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

IFN-γ Induces Pleural Mesothelial Cells to Recruit Immune Cells via CXCL10-CXCR3 Axis in a Mouse Pleurisy Model

Journal of Inflammation Research
Shu-Feng Dong,1,2,* Xin-Yu Shi,1,* Xiu-Zhi Wu,1 Feng-Shuang Yi1,3 1Department of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine and Beijing Chao-Yang Hospital, Capital Medical University, Beijing, 100020, People’
Dong SF, Shi X, Wu X, Yi FS
doaj  

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Acute exercise rewires the proteomic landscape of human immune cells. [PDF]

Nat Commun
Walzik D, Joisten N, Metcalfe AJ, Proschinger S, Schenk A, Wenzel C, Henneberg AL, Schneider M, Calderazzo S, Groll A, Watzl C, Opitz CA, Helm D, Zimmer P.   +13 more
europepmc   +1 more source