Results 211 to 220 of about 13,335,558 (318)

Complex genetic signatures in immune cells underlie autoimmunity and inform therapy

Nature Genetics, 2020
V. Orrù, M. Steri, C. Sidore, Michele Marongiu, Valentina Serra, S. Olla, G. Sole, Sandra Lai, Mariano Dei, A. Mulas, Francesca Virdis, M. Piras, M. Lobina, M. Marongiu, Maristella Pitzalis, F. Deidda, A. Loizedda, Stefano Onano, M. Zoledziewska, S. Sawcer, M. Devoto, M. Gorospe, G. Abecasis, M. Floris, Mauro Pala, D. Schlessinger, E. Fiorillo, F. Cucca   +27 more
semanticscholar   +1 more source

Antibiofilm activity of a chionodracine‐derived peptide by NMR‐based metabolomics of cell‐free supernatant of Acinetobacter baumannii clinical strains

FEBS Open Bio, EarlyView.
KHS‐Cnd peptide is able to impair biofilm formation and disaggregate mature biofilms in Acinetobacter baumannii clinical isolates. Differences in extracellular metabolites reflect changes in biofilm metabolism due to KHS‐Cnd treatment. Among the differentially represented extracellular metabolites upon KHS‐Cnd treatment, the significantly altered ...
Fernando Porcelli, Enrico Landi, Francesco Maiurano, Irene Paris, Rosanna Papa, Marco Artini, Laura Selan, Stefano Borocci, Francesco Buonocore, Esther Imperlini   +9 more
wiley   +1 more source

Bridging the gap: ferroptosis of immune cells in the tumor microenvironment. [PDF]

Front Immunol
Wang W, Li H, Liang S, Hu Y, Ding J, Wu X, Hua D.   +6 more
europepmc   +1 more source

Targeting CD5 to enhance immune T cell activation and function in treatment of solid tumours

, 2020
Faizah Alotaibi
openalex   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Deciphering metabolic reprogramming of immune cells within the tumor microenvironment. [PDF]

J Transl Med
Wang Y, Chen W, Wang Z, Cai S, Zhao X, Jin J, Gao T, Qu J.   +7 more
europepmc   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Immune cells: the key mediator between the gut microbiota and osteoporosis. [PDF]

Front Immunol
Ma T, Zhang T, Peng C, Liu K, Xiong Y, Chen K, Peng N, Wei Z, Kuang J, Ou L.   +9 more
europepmc   +1 more source

The Chinese Herbal Mixture Tien-Hsien Liquid Augments the Anticancer Immunity in Tumor Cell–Vaccinated Mice [PDF]

, 2016
Pei‐Ming Yang, Jia-Ling Du, George Nian-Kae Wang, Jean‐San Chia, Wei-Bin Hsu, Pin-Ching Pu, Andy Sun, Chun‐Pin Chiang, Won-Bo Wang   +8 more
openalex   +1 more source

Protein Tyrosine Phosphatase 4A1 (PTP4A1) Regulates Early Events in Colorectal Cancer Intraperitoneal Dissemination in the Aged Male Host

Aging and Cancer, EarlyView.
Colorectal cancer (CRC) mortality is highest in aged males. Pre‐clinical data comparing CRC i.p. metastasis in cohorts of young and aged, male and female mice support these finding. Bottom‐up proteomics of peritoneal mesothelial cells identified PTP4A1 as highly expressed in aged males and a role for PTP4A1 in heterotypic cell:cell adhesion was ...
Zhikun Wang, Yueying Liu, Jing Yang, Tyvette S. Hilliard, Reihaneh Safavi‐Sohi, Daniel D. Hu, Elizabeth I. Harper, Gena Dominique, Wanrui Wang, Jeffrey Johnson, Marwa Asem, William Milosevich, Julia Florek Carlson, Yunpeng Bai, Jinmin Miao, Zhong‐Yin Zhang, Matthew M. Champion, M. Sharon Stack   +17 more
wiley   +1 more source