Results 261 to 270 of about 3,195,227 (346)

The Aging Blood: Cellular Origins, Circulating Drivers, and Therapeutic Potential

Aging and Cancer, EarlyView.
As a conduit linking all organs, the blood system both reflects and actively drives systemic aging. This review highlights how circulating pro‐aging and antiaging factors and age‐associated hematopoietic stem cell dysfunction contribute to immunosenescence and multi‐organ decline, positioning the hematopoietic system as a target for aging intervention.
Hanqing He, Jianwei Wang
wiley   +1 more source

NAD + metabolism and function in innate and adaptive immune cells. [PDF]

J Inflamm (Lond)
Mann R, Stavrou V, Dimeloe S.
europepmc   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

Decoding SDCBP's role in tumor progression and immune cells infiltration: from databases to macrophage validation. [PDF]

Discov Oncol
Zhao C, Zhang C, Zhang X, Du C, Liu W, Zhou Q, Dong J, Yang F, Dang Y, Yang A, Wang M, Wang C, Li M.   +12 more
europepmc   +1 more source

Visual Recovery Reflects Cortical MeCP2 Sensitivity in Rett Syndrome

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Rett syndrome (RTT) is a devastating neurodevelopmental disorder with developmental regression affecting motor, sensory, and cognitive functions. Sensory disruptions contribute to the complex behavioral and cognitive difficulties and represent an important target for therapeutic interventions.
Alex Joseph Simon, Nathalie Picard, Valeria d'Andrea, Enchi Chang, Joseph Leffler, Eleonora Centofante, Matthew Taylor, Francesca Bardi, Francesca Cavicchiolo, Takao K. Hensch, Stefano Panzeri, Chinfei Chen, Michela Fagiolini   +12 more
wiley   +1 more source

Cholesterol efflux protein, ABCA1, supports anticancer functions of myeloid immune cells. [PDF]

Sci Adv
Bendre SV, Wang Y, Hajyousif B, K C R, Bhogale SG, Pradeep D, Krawczynska N, Schane CP, Weisser E, Singh A, Han S, Kim H, Kockaya L, Das Gupta A, Nelczyk AT, Vidana Gamage HE, Fei Y, Rodríguez-Casiano D, Guo X, Li H, Deaton RJ, Mo F, Sverdlov M, Gann PH, Sinha S, Sahni S, Wang K, Van Bortle K, Tajkorshid E, Woodward WA, Cho W, Nelson ER.   +31 more
europepmc   +1 more source

Systemic T Cell Receptor Profiling Reveals Adaptive Immune Activation and Potential Immune Signatures of Diagnosis and Brain Atrophy in Epilepsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Epilepsy is increasingly associated with immune dysregulation and inflammation. The T cell receptor (TCR), a key mediator of adaptive immunity, shows repertoire alterations in various immune‐mediated diseases. The unique TCR sequence serves as a molecular barcode for T cells, and clonal expansion accompanied by reduced overall TCR ...
Yong‐Won Shin, Sang Bin Hong, Yong Woo Shin, Inpyeong Hwang, Jaeseong Oh, Jihyeon Choi, Narae Kim, Jangsup Moon, Keun‐Hwa Jung, Kyung‐Il Park, Ki‐Young Jung, Kon Chu, Sang Kun Lee   +12 more
wiley   +1 more source

The impact of immune cells on the risk of breast cancer: a Mendelian randomization study. [PDF]

Discov Oncol
Zhang N, Wang H, Huang Z, Shen Z, Zhang P, Zhang G.   +5 more
europepmc   +1 more source

Interleukin‐6 as a Key Biomarker in Facioscapulohumeral Dystrophy: Evidence From Longitudinal Analyses

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Facioscapulohumeral muscular dystrophy type 1 (FSHD1) is a progressive neuromuscular disorder with no approved treatments. Identifying reliable biomarkers is critical to monitor disease severity, activity, and progression. Interleukin‐6 (IL‐6) has been proposed as a candidate biomarker, but longitudinal validation is limited ...
Jonathan Pini, Emanuela Martinuzzi, Sandra Dhifallah, Abderhmane Slioui, Angela Puma, Luisa Villa, Michele Cavalli, Andra Ezaru, Jérémy Garcia, Manuela Gambella, Federico Torre, Luca Jacopo Pavan, Nicolas Glaichenhaus, Sabrina Sacconi   +13 more
wiley   +1 more source

Single-cell landscape of peripheral and tumor-infiltrating immune cells in HPV-negative HNSCC. [PDF]

Oncoimmunology
Galvani RGA, Hidalgo AAR, Biagi-Junior CA, Matuck BF, Krol JMM, Rupp B, Kumar N, Huynh K, Liu J, Sheth S, Maracaja-Coutinho V, Byrd KM, Severino P.   +12 more
europepmc   +1 more source