Results 321 to 330 of about 2,266,569 (385)

Role of microbiota in the outcome of immune checkpoint inhibition therapy of cancer. [PDF]

Explor Target Antitumor Ther
Rijkers GT, Langcauon Y, van Leersum P, Popović L, van Overveld FJ.   +4 more
europepmc   +1 more source

Supplementary Figure 17 from Preclinical Development of SGN-CD47M: Protease-Activated Antibody Technology Enables Selective Tumor Targeting of the Innate Immune Checkpoint Receptor CD47

Matthew R. Levengood, Christopher M. Carosino, Xinqun Zhang, Sasha Lucas, David J. Ortiz, Lori Westendorf, Alice Chin, Arlan D. Martin, Abbie Wong, Shawna Hengel, Hao Sun, Weiping Zeng, Roma Yumul, Melissa M.C. Dominguez, Yufei Chen, Janet H. Zheng, Caroline Karlsson, Vivian H. Trang, Peter D. Senter, Shyra J. Gardai   +19 more
openalex   +1 more source

Flipping the Switch: MeCP2‐Mediated Lactylation Rewires Microglial Metabolism and Inflammation via the HK2/mTOR Axis in Poststroke Neuroinflammation

Advanced Science, EarlyView.
Stroke‐induced lactate accumulation promotes p300‐mediated lactylation of methyl‐CpG binding protein 2 (MeCP2) at lysine 210, which reprograms microglial metabolism toward glycolysis and activates the hexokinase 2 (HK2)/mTOR axis. This cascade promotes proinflammatory responses and impairs neurofunctional outcomes.
Zengyu Zhang, Shanshan Huang, Yong Wang, Zhiwen Jiang, Zhuohang Liu, Chenran Wang, Rong Ji, Yiwen Yuan, Xueyu Mao, Kaicheng Yang, Huicong Niu, Yanqin Gao, Jing Zhao   +12 more
wiley   +1 more source

The impact of immune checkpoint inhibitors on gonadal function in patients with solid tumors. [PDF]

ESMO Open
van Dijk B, de Joode K, Louwers YV, Verheul HMW, Mathijssen RHJ, Chaker L, van der Wal R, van den Berg SAA, Dinkelman-Smit M, Visser JA, van der Veldt AAM.   +10 more
europepmc   +1 more source

Cancer Stem Cells Shift Metabolite Acetyl‐Coenzyme A to Abrogate the Differentiation of CD103+ T Cells

Advanced Science, EarlyView.
Lei et al. demonstrate that cancer stem cells (CSCs) play a pivotal role in impairing the differentiation of CD103+ T cells in patients with non‐small‐cell lung cancer. The key mechanism involves CSC‐derived acetyl‐CoA, which disrupts CD103+ T cell differentiation by sequentially inducing acetylation and ubiquitination of the Blimp‐1 protein. Targeting
Jiaxin Lei, Huiyan Ji, Jing Guo, Mengdi Liu, Danhua Su, Yiran Zheng, Lin Xu, Qinghua Cao, Tao Ren, Jun Gui, Zhenke Wen   +10 more
wiley   +1 more source

Identification and validation of cuproptosis-related immune checkpoint expression for glioblastoma. [PDF]

BMC Cancer
Huang J, Tong S, Liu J, Hua S, Zhang J, Mungur R, Liu S, Feng J, Tang B, Zeng J.   +9 more
europepmc   +1 more source

Supplementary Figure S5 from Autocrine 17-β-estradiol/estrogen receptor-α loop determines the response to immune-checkpoint inhibitors in non-small cell lung cancer

Dario P. Anobile, Iris C. Salaroglio, Fabrizio Tabbò, Sofia La Vecchia, Muhlis Akman, Francesca Napoli, Maristella Bungaro, Federica Benso, Elisabetta Aldieri, Paolo Bironzo, Joanna Kopecka, Francesco Passiglia, Luisella Righi, Silvia Novello, Giorgio V. Scagliotti, Chiara Riganti   +15 more
openalex   +1 more source

Immune Checkpoint Inhibitor Endocrinopathies-Insights From 3 Unusual Cases. [PDF]

JCEM Case Rep
Husebye ES.
europepmc   +1 more source

Figure S11 from A Phase II Trial of Guadecitabine plus Atezolizumab in Metastatic Urothelial Carcinoma Progressing after Initial Immune Checkpoint Inhibitor Therapy

H. Josh Jang, Galen Hostetter, Alexander W. Macfarlane, Zachary Madaj, Eric A. Ross, Toshinori Hinoue, Justin R. Kulchycki, Ryan S. Burgos, Mahvish Tafseer, R. Katherine Alpaugh, Candice L. Schwebel, Rutika Kokate, Daniel M. Geynisman, Matthew R. Zibelman, Pooja Ghatalia, Peter W. Nichols, Woonbok Chung, Jozef Madžo, Noah M. Hahn, David I. Quinn, Jean‐Pierre J. Issa, Michael J. Topper, Stephen B. Baylin, Hui Shen, Kerry S. Campbell, Peter A. Jones, Elizabeth R. Plimack   +26 more
openalex   +1 more source