Results 341 to 350 of about 2,266,569 (385)
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Hematology/Oncology Clinics of North America, 2014
Since the development and approval of Ipilimumab, the first immune checkpoint inhibitor licensed for the treatment of metastatic melanoma, clinicians have gained a better understanding of the mode of action, management of toxicities, and assessment of response to this class of drugs.
Jarushka, Naidoo +2 more
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Since the development and approval of Ipilimumab, the first immune checkpoint inhibitor licensed for the treatment of metastatic melanoma, clinicians have gained a better understanding of the mode of action, management of toxicities, and assessment of response to this class of drugs.
Jarushka, Naidoo +2 more
openaire +2 more sources
Epigenetics Meets Immune Checkpoints
Seminars in Oncology, 2015Epigenetic alterations play a pivotal role in cancer development and progression. Pharmacologic reversion of such alterations is feasible, and second generation "epigenetic drugs" are in development and have been demonstrated to possess significant immunomodulatory properties.
Covre A. +5 more
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Immune Checkpoint Inhibitor Toxicity
Current Oncology Reports, 2018Immune checkpoint inhibitors have revolutionised the treatment of multiple malignancies and have a growing list of indications. As our familiarity with these agents grows, so does our understanding of their unique spectrum of toxicities. Here, we will review the literature regarding the toxicities of checkpoint inhibitors and address challenges ...
David J, Palmieri, Matteo S, Carlino
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Microglial immune checkpoint mechanisms
Nature Neuroscience, 2018Microglia differentiate from progenitors that infiltrate the nascent CNS during early embryonic development. They then remain in this unique immune-privileged environment throughout life. Multiple immune mechanisms, which we collectively refer to as microglial checkpoints, ensure efficient and tightly regulated microglial responses to perturbations in ...
Aleksandra Deczkowska +2 more
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Immune checkpoint inhibitor myocarditis
Current Opinion in Cardiology, 2019The purpose of this study is to summarize and highlight the recent literature regarding immune checkpoint inhibitor myocarditis.The use of immune checkpoint inhibitors, a promising form of immunotherapy, is rapidly increasing in oncology. These drugs have been recently found to cause a fulminant myocarditis associated with a high-case fatality rate ...
Jayant, Raikhelkar, Nir, Uriel
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Immune checkpoint for pregnancy
Seminars in ImmunopathologyA successful pregnancy relies on the precise regulation of the maternal immune system to recognize and tolerate the allogeneic fetus, while simultaneously preventing infection. Immune checkpoint molecules (ICMs), such as programmed death receptor 1 (PD-1), cytotoxic T-lymphocyte antigen 4 (CTLA-4), T cell immunoglobulin, and mucin-domain containing-3 ...
Xiaohui Hu, Siying Lai, Aihua Liao
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Combined Immune Checkpoint Blockade
Seminars in Oncology, 2015There are very few tumor types for which chemotherapy regimens are regularly curative; notable exceptions include testicular cancer and Hodgkin's lymphoma. In both cases combination chemotherapy approaches are required. Thus, it would seem only logical that combination immunotherapy approaches will be required to induce long-term remissions in the ...
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Managing Resistance to Immune Checkpoint Inhibitors in Lung Cancer: Treatment and Novel Strategies.
Journal of Clinical Oncology, 2022A proportion of patients with lung cancer experience long-term clinical benefit with immune checkpoint inhibitors (ICIs). However, most patients develop disease progression during treatment or after treatment discontinuation.
A. Passaro +4 more
semanticscholar +1 more source
Immune Checkpoint Inhibitor–Induced Lipodystrophy
JAMA DermatologyThis case series describes lipodystrophy, a rare adverse event associated with immune checkpoint inhibitor therapy.
Riganti J. +15 more
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2017
Tumor cell transformation prompts to activation of adaptive and innate immune responses, which had a crucial role in eliminating and controlling early cancer growth. Over the past 10 years, there has been a greater understanding of the immune response to tumors which has led to the development of a huge number of immunotherapeutic strategies [1, 2 ...
Angela Esposito, Giuseppe Curigliano
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Tumor cell transformation prompts to activation of adaptive and innate immune responses, which had a crucial role in eliminating and controlling early cancer growth. Over the past 10 years, there has been a greater understanding of the immune response to tumors which has led to the development of a huge number of immunotherapeutic strategies [1, 2 ...
Angela Esposito, Giuseppe Curigliano
openaire +1 more source