Results 141 to 150 of about 161,983 (298)

Pre‐Encoded IFN‐I Sensitivity Exacerbates Memory T Cell Senescence in Solid Tumors

Advanced Science, EarlyView.
Type I interferon (IFN‐I) signaling promotes p21‐dependent cell cycle arrest in senescent tumor‐specific memory T cells, resulting in poor proliferative responses and solid tumor regression during cancer vaccination. Conversely, IFNα/β receptor blockade reinvigorates T cell proliferation to regress solid tumors and is more effective with increasing ...
Andrew Nguyen, Scott R Walsh, Li Deng, Lan Chen, Yonghong Wan   +4 more
wiley   +1 more source

A1-reprogrammed mesenchymal stromal cells prime potent antitumoral responses

iScience
Summary: Mesenchymal stromal cells (MSCs) have been modified via genetic or pharmacological engineering into potent antigen-presenting cells-like capable of priming responding CD8 T cells.
Marina Pereira Gonçalves, Roudy Farah, Jean-Pierre Bikorimana, Jamilah Abusarah, Nehme EL-Hachem, Wael Saad, Sebastien Talbot, Daniela Stanga, Simon Beaudoin, Sebastien Plouffe, Moutih Rafei   +10 more
doaj   +1 more source

T Cell Glycoengineering to Modulate Immune‐Tumor Crosstalk: A Universal Non‐Genetic Strategy for Enhanced Tumor Immunotherapy

Advanced Science, EarlyView.
This study describes a T cell surface engineering strategy that integrates polymer materials with tumor immunology, aiming to achieve broad‐spectrum anti‐tumor applications of glycopolymer‐engineered T (G‐T) cells via non‐genetic modification. Glycopolymer engineering generally modulates immune‐tumor crosstalk through specific cell‐cell interactions ...
Lihua Yao, He Yang, Fangjian Shan, Xiaomeng Niu, Yichen Wang, Hengyuan Zhang, Sujian Wang, Gaojian Chen, Hong Chen   +8 more
wiley   +1 more source

Additional file 1 of Targeting MUS81 promotes the anticancer effect of WEE1 inhibitor and immune checkpoint blocking combination therapy via activating cGAS/STING signaling in gastric cancer cells

, 2021
Chengguo Li, Qian Shen, Peng Zhang, Tao Wang, Weizhen Liu, Ruidong Li, Xianxiong Ma, Xiangyu Zeng, Yuping Yin, Kaixiong Tao   +9 more
openalex   +1 more source

Integrated Transcriptomics Reveals Evolutionary Trajectories and Cell Density‐Dependent Mechanisms in Aldosterone‐Producing Adenomas

Advanced Science, EarlyView.
Aldosterone‐producing adenomas (APAs) develop via two distinct paths: directly from adrenal zona glomerulosa (zG) cells, or stepwise from zG cells through aldosterone‐producing micronodules (APMs) before progressing to APAs. Advanced single‐cell and spatial analyses identified distinct cell states linked to oxidative stress and cell–cell interactions ...
Zhuolun Sun, Changying Jing, Martina Tetti, Siyuan Gong, Jia Wei, Yingxian Pang, Martin Reincke, Tracy Ann Williams   +7 more
wiley   +1 more source

miR-424(322) reverses chemoresistance via T-cell immune response activation by blocking the PD-L1 immune checkpoint [PDF]

, 2016
Shaohua Xu, Zhen Tao, Bo Hai, Liang Huagen, Ying Shi, Tao Wang, Wen Song, Yong Chen, Jun Ouyang, Jinhong Chen, Fanfei Kong, Yishan Dong, Shi-Wen Jiang, Wei-Yong Li, Ping Wang, Zhiyong Yuan, Xiaoping Wan, Chenguang Wang, Wencheng Li, Xiaoping Zhang, Ke Chen   +20 more
openalex   +1 more source

Additional file 2 of Targeting MUS81 promotes the anticancer effect of WEE1 inhibitor and immune checkpoint blocking combination therapy via activating cGAS/STING signaling in gastric cancer cells

, 2021
Chengguo Li, Qian Shen, Peng Zhang, Tao Wang, Weizhen Liu, Ruidong Li, Xianxiong Ma, Xiangyu Zeng, Yuping Yin, Kaixiong Tao   +9 more
openalex   +1 more source

FAPα+ Macrophages Orchestrate Immune Evasion in Multiple Myeloma by Dual Regulation of PD‐L1 and T Cell Senescence

Advanced Science, EarlyView.
Fibroblast activation protein alpha‐positive (FAPα+) macrophages, a distinct subset of multiple myeloma (MM)‐associated macrophages, drive immune evasion in MM through multi‐faceted mechanisms. FAPα physically interacts with vimentin (VIM) and triggers its phosphorylation at the S72 residue, which in turn induces PD‐L1 transcription. Additionally, FAPα
Huiyao Gu, Zhenfeng Dai, Xi Huang, Enfan Zhang, Xinyuan Dai, Haoguang Chen, Wen Cao, Jinna Zhang, Yifan Hou, Haimeng Yan, Yang Yang, Li Yang, Yi Li, Wenlong Lin, Zhen Cai, Jingsong He   +15 more
wiley   +1 more source

Hypothyroidism During Immune Checkpoint Inhibitor Therapy That Is Not Responsive to Thyroxin Substitution. A Peripheral T4-T3 Conversion Block?

, 2021
Faro R. Verelst, Michiel Beyens, Elke Vandenbroucke, Kathleen Forceville, Marcel Twickler   +4 more
openalex   +1 more source

Interactions of Antibody Drug Conjugate Anti‐Tubulin and Topoisomerase I Inhibitor Payloads with Radiotherapy to Potentiate Immunotherapy

Advanced Science, EarlyView.
Antibody drug conjugates deliver their cytotoxic anti‐tubulin or topoisomerase I inhibitor payloads to tumors through cancer cell receptor targeting. The released drug payloads induce cellular changes that interact with radiotherapy resulting in radiosensitization that improves cancer cell kill and stimulates anti‐tumor immune responses.
Jacqueline Lesperance, Bryan S. Yung, Michael M. Allevato, Marcus M Cheng, Maria F. Camargo, Robert Saddawi‐Konefka, Kanika Dhawan, Ashwyn K. Sharma, Mahsa Mortaja, Sophie Bice, Daniel J. Scanderbeg, Diego Alvarado, Jyoti Mayadev, Ramez N. Eskander, Stephen R. Adams, Pippa F. Cosper, J. Silvio Gutkind, Sunil J. Advani   +17 more
wiley   +1 more source