Results 231 to 240 of about 161,983 (298)

CTLA-4 and targeted immunotherapy-a key link in the systemic influence of periodontitis: a mini review. [PDF]

Front Dent Med
Thanigaimalai A, Ravindran DM, Balaji SK, Bhuvaneswari B, SriSanjhanaa C.   +4 more
europepmc   +1 more source

Dupilumab for the treatment of immune checkpoint blockers' induced pruritus

, 2023
Panou, Evdoxia, Stavridi, Flora, Nikolaou, Christos, Stratigos, Alexander, Nikolaou, Vasiliki   +4 more
openaire   +1 more source

GlycoChat Uncovers Glycan–Lectin Circuits in the Tumor Microenvironment of Pancreatic Cancer

Advanced Science, EarlyView.
Aberrant glycosylation drives cancer progression, yet its role in the tumor microenvironment remains unclear. We developed GlycoChat to map glycan–lectin circuits at single‐cell resolution. We discovered that cancer cells induce immunosuppressive macrophage differentiation and impair phagocytosis through interactions with CLEC10A and SIGLEC3 ...
Dinh Xuan Tuan Anh, Sunanda Keisham, Arun Burramsetty, Lalhaba Oinam, Koichiro Kumano, Akihiro Kuno, Osamu Shimomura, Tatsuya Oda, Hiroaki Tateno   +8 more
wiley   +1 more source

Logic‐Gated HSV‐TK/GCV Suicide Gene Circuit for Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
The BRAS comprises two modular genetic components driven by distinct tumor‐specific promoters and a failsafe layer with the NOT gate. This multi‐input logic gate circuit enables precise, specific expression of HSV‐TK in breast cancer cells with hardly expression in normal cell and effectively inhibits tumor growth in a triple‐negative breast cancer ...
Shasha Tang, Yuan Fang, Lingli Jin, Dongyang Liu, Yicheng Liu, Ruijia Zheng, Liyun Yong, Xin Wu, Longliang Qiao, Meiyan Wang, Fengfeng Cai   +10 more
wiley   +1 more source

Angiotensin receptor-neprilysin inhibitors improve the outcome of lung cancer patients with hypertension undergoing immune checkpoint inhibitors treatment. [PDF]

BMC Cardiovasc Disord
Shang C, Wang H, Chen J, Cao S, Sun Y, Sheng Z, Chu T, Zhao L.   +7 more
europepmc   +1 more source

CD20+FCRL4+ B Cells Activate CD8+ T Cells via MHC‐I Restriction in Nasopharyngeal Carcinoma Anti‐Tumor Immunity

Advanced Science, EarlyView.
CD20⁺FCRL4⁺ B cells in nasopharyngeal carcinoma actively cross‐present exogenous tumor antigens via MHC‐I, enhancing CD8⁺ T‐cell activation, memory formation, and cytotoxicity. IFNγ‐driven WDFY4 upregulation facilitates this process. These findings reveal an unconventional B‐cell–mediated antitumor mechanism and indicate potential relevance to ...
Benjian Zhang, Xiaotian Yuan, Kelei Gao, Bo You, Yaxuan Wang, Lai Meng, Zirong Chen, Shaobing Xie, Yunqing Liu, Zijian Dong, Shumin Xie, Ruohao Fan, Fengjun Wang, Junyi Zhang, Zhihai Xie, Yongzhen Mo, Hua Zhang, Weihong Jiang   +17 more
wiley   +1 more source

Takotsubo Syndrome Triggered by Immune Checkpoint Inhibitor-Induced Pneumonitis: A Multidisciplinary Diagnostic and Therapeutic Challenge. [PDF]

Am J Case Rep
Kaldas M, Shah M, Ivanova V, Alnaimat S, Pashaieva D, Williams R, Radhakrishnan A.   +6 more
europepmc   +1 more source

Parallel Genome‐Wide CRISPR Screens Reveal SORL1 and ZFYVE19 as Sequential Host Determinants of Salmonella Infection

Advanced Science, EarlyView.
To distinguish how Salmonella invades cells vs how it survives long‐term, a parallel CRISPR screening platform is developed. This approach reveals the host proteins that the bacterium exploits at different stages of infection. The study identifies SORL1 as a novel host factor for invasion and demonstrates that blocking it with an antibody effectively ...
Sehee Yun, Seoyeon Kim, Seonggyu Kim, Minsoo Noh, Dae‐Kyum Kim, Eun‐Jin Lee, Hunsang Lee   +6 more
wiley   +1 more source

Pharmacovigilance Insights Into Immune Checkpoint Inhibitor-Induced Risk of Paraneoplastic Syndrome: A Large-Scale Real World Study. [PDF]

CNS Neurosci Ther
Tang B, Song X, Sun Y, Wan J, Hu W, Ma Y, Lin Y, Zhang J, Wang Y, Feng H, Luo P, Guo D, Qu X.   +12 more
europepmc   +1 more source

Supplementary Data1 from Metabolic Tumor Volume Assessed by 18F FDG–PET CT Scan as a Predictive Biomarker for Immune Checkpoint Blockers in Advanced NSCLC and Its Biological Correlates

Filippo Gustavo Dall’Olio, Wael Zrafi, Véronique Roelants, Valentina Ambrosini, Aloÿse Fourquet, Cristina Mitea, Francesco Passiglia, Matteo Bauckneht, G. Bonardel, Nicole Conci, José Carlos Benítez, Vincenzo Arena, Céline Namour, Marie Naigeon, Isabelle Monnet, Kristi Beshiri, Delphine Hoton, Safiye Dursun, François‐Xavier Danlos, Giulia Argalia, Mihaela Aldea, Guido Rovera, Lisa Derosa, Valerio Iebba, Hester A. Gietema, V. Gounant, Valérie Lacroix, Jordi Remón, Daniel Gautheret, Nathalie Chaput, Bastien Job, Patricia Kannouche, Monica Velasco-Nuño, Laurence Zitvogel, Eugenia Cella, J. Freitas, Damien Vasseur, M.A. Bettaieb, Marco Tagliamento, Lizza Hendriks, Antoîne Italiano, David Planchard, Aurélien Marabelle, Fabrice Barlési, Silvia Novello, Désirèe Deandreis, Frank Aboubakar Nana, Andrea Ardizzoni, Gérard Zalcman, Camilo Garcia, Benjamin Besse   +50 more
openalex   +1 more source