Results 161 to 170 of about 268,746 (338)

461 Circadian control of the tumor immune microenvironment determines immune checkpoint inhibitor efficacy [PDF]

Jake Lichterman, Tarun Srinivasan, Ruheng Wang, Chaitanya Dende, Mitchell S. von Itzstein, Jialiang Liu, Jorge H Ramírez, Wenling Li, Laura Coughlin, Nicole Poulides, Parastoo Sabaeifard, Tian Zhang, Hans J. Hammers, Xin Li, Bret M. Evers, Xiaowei Zhan, David E. Gerber, Lora V. Hooper, Andrew Y. Koh   +18 more
openalex   +1 more source

Comparative Effectiveness of Immune Checkpoint Inhibitors vs Chemotherapy by Tumor Mutational Burden in Metastatic Castration-Resistant Prostate Cancer [PDF]

, 2022
Ryon P. Graf, Virginia Fisher, Janick Weberpals, Ole Gjoerup, Marni Brisson Tierno, Richard S.P. Huang, Nicolas Sayegh, Douglas I. Lin, Kira Raskina, Alexa B. Schrock, Eric A. Severson, James Haberberger, Jeffrey S. Ross, James Creeden, Mia Levy, Brian M. Alexander, Geoffrey R. Oxnard, Neeraj Agarwal   +17 more
openalex   +1 more source

Decellularized Extracellular Matrix Scaffolds to Engineer the Dormant Landscape of Microscopic Colorectal Cancer Liver Metastasis

Advanced Healthcare Materials, EarlyView.
Decellularized liver extracellular matrix scaffolds provide a platform to study dormant liver‐metastatic colorectal cancer. They induce reversible dormancy, in combination with nutrient depletion and low dose chemotherapy, through cell cycle arrest and chemotherapy resistance.
Sabrina N. VandenHeuvel, Lucia L. Nash, Abigail J. Clevenger, Claudia A. Collier, Oscar R. Benavides, Sanjana Roy, Brinlee Goggans, Aelita Salikhova, Anvitha Tharakesh, Svasti Haricharan, Amber N. Stratman, Scott Kopetz, Alex J. Walsh, Shreya A. Raghavan   +13 more
wiley   +1 more source

Basal cell carcinoma: Management of advanced or metastatic cancer with checkpoint inhibitors and concurrent paradoxical development of new superficial tumors. [PDF]

, 2020
Cohen, Philip R, Kurzrock, Razelle
core   +1 more source

Bioengineered Pancreatic Cancer Immunosuppressive Microenvironment Models for Screening Immunotherapies

Advanced Healthcare Materials, EarlyView.
Bioengineering tumor‐stroma pancreatic cancer models with potential to emulate the native immunosuppressive tumor microenvironment. Cancer‐on‐a‐bead models exhibited higher relevance for screening immunotherapies and modulating the protumoral PDAC microenvironment. ABSTRACT Pancreatic cancer is notably resistant to treatment, primarily due to its dense
Maria V. Monteiro, Margarida Henriques‐Pereira, Bruno M. Neves, Vítor M. Gaspar, João F. Mano   +4 more
wiley   +1 more source

Remote‐Controllable Immune‐Priming Spot Formation Via Nanocomplexed Hydrogel‐Assisted Histotripsy: Immunoasis

Advanced Materials, EarlyView.
A novel immunotherapeutic strategy combines injectable, adjuvant‐loaded hydrogels with externally controlled histotripsy to create immune‐priming sites within tumors. This approach generates millimeter‐sized immune‐activated lesions with flexible, patient‐tailored treatment scheduling, enabling precise immune activation through tumor ablation‐mediated ...
Sung Hoon Kim, Wonseok Choi, Yurim Kim, Hyeongmin Kim, Gu Won Jeong, Hyewon Park, Inchan Youn, Yoon Park, Sungmin Han, Young‐Min Kim   +9 more
wiley   +1 more source

Supplementary Materials and Methods from Activation of the IFN Signaling Pathway is Associated with Resistance to CDK4/6 Inhibitors and Immune Checkpoint Activation in ER-Positive Breast Cancer [PDF]

, 2023
Carmine De Angelis, Xiaoyong Fu, Maria Letizia Cataldo, Agostina Nardone, Resel Pereira, Jamunarani Veeraraghavan, Sarmistha Nanda, Lanfang Qin, Vidyalakshmi Sethunath, Tao Wang, Susan G. Hilsenbeck, Matteo Benelli, Ilenia Migliaccio, Cristina Guarducci, Luca Malorni, Lacey M. Litchfield, Jiangang Liu, Joshua Donaldson, Pier Selenica, D. N. Brown, Britta Weigelt, Jorge S. Reis‐Filho, Ben Ho Park, Sara A. Hurvitz, Dennis J. Slamon, Mothaffar F. Rimawi, Valerie M. Jansen, Rinath Jeselsohn, C. Kent Osborne, Rachel Schiff   +29 more
openalex   +1 more source

Immune Checkpoint Inhibitor Use in Sepsis: Monitoring Immune Checkpoint Inhibitor Toxicity

Critical Care Medicine, 2019
Karthik, Suresh, Franco, D'Alessio
openaire   +3 more sources

Multiphysics‐Driven Assembly of Biomimetic Vesicles

Advanced Materials, EarlyView.
Artificial extracellular vesicles, derived from cell membranes, are manufactured using a multiphysics‐integrated microfluidic platform that combines nanoknife membrane rupture, herringbone chaotic mixing, and acoustothermal modulation. This standardizable workflow enables the predictable control of vesicle formation and therapeutic loading, while ...
Timofei Solodko, Ian Gimino, Aastha Chandiwala, Bayan Alkotoub, Ali Bashiri Dezfouli, Heiko Reith, Asjad Bakhtiar, Rojda Hicsanmaz, Johann Brenner, Christoph J. O. Kaiser, Elena Belli, Shilpi Pandey, Samuel D. Rabkin, Kornelius Nielsch, Gabriele Multhoff, Oliver Hayden, Morteza Hasanzadeh Kafshgari   +16 more
wiley   +1 more source

Smart REASSURED Sensors via Machine‐Augmented Printable On‐Paper Arrays

Advanced Sensor Research, EarlyView.
This perspective highlights the emerging role of pattern‐recognition, printable on‐paper sensor arrays for intelligent PoC diagnostics. It discusses how paper's inherent limitations can be overcome through surface modification and scalable printing, and how machine‐learning analysis of cross‐reactive arrays enables multiplexed, low‐cost, and REASSURED ...
Naimeh Naseri, Saba Ranjbar
wiley   +1 more source