Results 241 to 250 of about 268,746 (338)

Troponin Surveillance in Patients Receiving Immune Checkpoint Inhibitors. [PDF]

JACC CardioOncol
Ostos-Mendoza KC, L McQuade J, Palaskas NL.   +2 more
europepmc   +1 more source

Notch2 Directs aTreg Cell Fate toward Immunoregulation or Inflammatory Pyroptosis

Advanced Science, EarlyView.
Schematic illustration showing that the Notch2 intracellular domain (NICD2) facilitates pyroptosis resistance in activated Tregs through the RREB1/Foxo1 signaling pathway. In addition, Notch2‐mediated pyroptosis resistance in activated Tregs promotes immunoregulatory capacity, thereby attenuating Th2‐driven inflammatory responses in allergic rhinitis ...
Yue‐Long Qiao, Shan Xu, You Zou, Rui Yang, Han Zheng, Jia‐Yu Liu, Hui‐Ming Fan, Yuan‐Yuan Zhang, Yong‐Gang Kong, Wo‐Er Jiao, Shi‐Ming Chen   +10 more
wiley   +1 more source

Eosinophils and the Efficacy of Immune Checkpoint Inhibitors Across Multiple Cancers: A Retrospective Study. [PDF]

Biomedicines
Suzuki R, Ohkuma R, Watanabe M, Mura E, Tsurui T, Iriguchi N, Ishiguro T, Hirasawa Y, Ikeda G, Shimokawa M, Ariizumi H, Kubota Y, Yoshimura K, Kobayashi S, Tsunoda T, Horiike A, Tsuji M, Kiuchi Y, Oguchi T, Wada S.   +19 more
europepmc   +1 more source

Precision Editing of NLRS Improves Effector Recognition for Enhanced Disease Resistance

Advanced Science, EarlyView.
Precision engineering of plant NLR immune receptors enables rational design of enhanced pathogen resistance through mismatched pairing, domain swapping, and targeted mutagenesis. These approaches achieve multi‐fold expansion in recognition breadth while minimizing autoimmunity risks and fitness penalties.
Vinit Kumar, Vishwa I. P. W. A. Kumara, Pradeepa C. G. Bandaranayake, Dong Yawen, Yang‐Yang Gao, Junfeng Liu, Ge‐Fei Hao, Xiu‐Fang Xin   +7 more
wiley   +1 more source

Testicular Function After Immune-Checkpoint Inhibitors Treatment. [PDF]

Clin Endocrinol (Oxf)
Boutros A, Idan A, Sleiman S, Bacha F, Zhang T, Jayadev V, Menzies AM, Long GV, Handelsman DJ.   +8 more
europepmc   +1 more source

Discontinuation of immune checkpoint inhibitors in hepatocellular carcinoma: a retrospective cohort study

Liuyu Zhou, Yuhong Zhang, Jie Zheng, Minghao Ruan, Jin Zhang, Yao Li, Riming Jin, Dong Wu, Hanyong Sun, Jianjun Zhang, Ruoyu Wang   +10 more
openalex   +1 more source

Elemene Augments the Effects of Anti‐PD‐1 Immunotherapy on Hepatocellular Carcinoma by Regulating the miR‐130a‐5p/SPP/MHC‐I Axis

Advanced Science, EarlyView.
Elemene increases SPP expression by competitively binding with miR‐130a‐5p to suppress SPP mRNA degradation. This led to more antigen/MHC‐I complexes being expressed on the cell surface, which consequently facilitated the recognition and killing of HCC cells by CTLs and enhancing the antitumor immune efficacy of anti‐PD‐1.
Menglan Wang, Mengqing Sun, Heng Dong, Xiaoting Zhang, Jingbo Zhang, Zhengguo Zhang, Mengjie Ni, Lina Li, Yunxin Pei, Xiaoyu Chen, Qian Li, Fangtian Bu, Jiacheng Huang, Liangyu Jiang, Zhuting Fang, Xuliang Chen, Jianxiang Chen, Yiting Qiao, Tian Xie   +18 more
wiley   +1 more source

Multiple or Single Endocrine Abnormalities Associated With Immune Checkpoint Inhibitors.

J Clin Endocrinol Metab
Kamitani F, Nishioka Y, Nakajima H, Kurematsu Y, Okada S, Myojin T, Noda T, Imamura T, Takahashi Y.   +8 more
europepmc   +1 more source

The Search for Predictive Biomarkers in Response to Immune Checkpoint Inhibitors and Associated Adverse Events. [PDF]

J Pers Med
Agostini M, Traldi P, Hamdan M.
europepmc   +1 more source

Author response: Opposing Regulation of TNF Responses by IFN-γ and a PGE2-cAMP Axis that is Apparent in Rheumatoid and Immune Checkpoint Inhibitor-induced Arthritis IL-1β+ Macrophages

Upneet K. Sokhi, Ruoxi Yuan, Bikash Mishra, Yuri Chinenov, Anvita Singaraju, Karmela K Chan, Anne R. Bass, Richard D. Bell, Laura T. Donlin, Lionel B. Ivashkiv   +9 more
openalex   +1 more source