Results 51 to 60 of about 2,310,452 (384)

Markers of immune dysregulation in pediatric patients with severe bronchiolitisMarker of immune dysregulation in bronchiolitis [PDF]

Journal of Human Immunity
Children with bronchiolitis exhibit a unique immunophenotype. We identify a significant difference in plasmacytoid dendritic cells and eosinophils in hospitalized patients as compared to controls, as well as cytokines involved in airway inflammation that
Katherine Hickey, Conor Gruber, Sofija Buta-Panov, Jo Hsuan Lee, Guillaume Stoffels, Sandeep Gangadharan, Alfin Vicencio, Dusan Bogunovic   +7 more
doaj   +1 more source

Microvascular significance of TGF-β axis activation in COVID-19

Frontiers in Cardiovascular Medicine, 2023
As 2023 approaches, the COVID-19 pandemic has killed millions. While vaccines have been a crucial intervention, only a few effective medications exist for prevention and treatment of COVID-19 in breakthrough cases or in unvaccinated or immunocompromised ...
Lauren M. Arguinchona, Caterina Zagona-Prizio, Megan E. Joyce, Edward D. Chan, Edward D. Chan, Edward D. Chan, James P. Maloney   +6 more
doaj   +1 more source

Gain-of-function IKZF1 variants in humans cause immune dysregulation associated with abnormal T/B cell late differentiation

Science immunology, 2022
IKZF1/IKAROS is a key transcription factor of lymphocyte development expressed throughout hematopoiesis. Heterozygous germline IKZF1 haploinsufficient (IKZF1HI) and dominant-negative (IKZF1DN) variants in humans cause B cell immune deficiency and ...
A. Hoshino, D. Boutboul, Yuan Zhang, H. Kuehn, J. Hadjadj, N. Özdemir, T. Celkan, C. Walz, C. Picard, C. Lenoir, N. Mahlaoui, C. Klein, Xiao Peng, A. Azar, E. Reigh, M. Cheminant, A. Fischer, F. Rieux-Laucat, I. Callebaut, F. Hauck, J. Milner, S. Rosenzweig, S. Latour   +22 more
semanticscholar   +1 more source

Immune dysregulation in immunoglobulin G4–related disease

Japanese Dental Science Review, 2023
(IgG4-RD) is an immune-mediated fibrotic disorder characterized by severe resolution of inflammation and dysregulation of wound healing. IgG4-RD has been considered a unique disease since 2003, and significant progress has been achieved in the ...
Takashi Maehara, Risako Koga, Seiji Nakamura   +2 more
doaj   +1 more source

Association of a MET genetic variant with autism-associated maternal autoantibodies to fetal brain proteins and cytokine expression. [PDF]

, 2011
The contribution of peripheral immunity to autism spectrum disorders (ASDs) risk is debated and poorly understood. Some mothers of children with ASD have autoantibodies that react to fetal brain proteins, raising the possibility that a subset of ASD ...
Ashwood, P, Braunschweig, D, Campbell, DB, Heuer, L, Van de Water, J   +4 more
core   +2 more sources

Diagnostic Challenges in Patients with Inborn Errors of Immunity with Different Manifestations of Immune Dysregulation

Journal of Clinical Medicine, 2022
Inborn errors of immunity (IEI), formerly known as primary immunodeficiency disorders (PIDs), are inherited disorders caused by damaging germline variants in single genes, which result in increased susceptibility to infections and in allergic, autoimmune,
Karolina Pieniawska-Śmiech, Gerard Pasternak, A. Lewandowicz-Uszyńska, M. Jutel   +3 more
semanticscholar   +1 more source

Immune dysregulation in Down syndrome

Nature Reviews Immunology, 2023
The immune system in individuals with Down syndrome is characterized by steady state increases in cytokine expression, T cell activation, atypical B cell responses and the presence of numerous autoantibodies.
openaire   +2 more sources

Mass Cytometry Reveals Global Immune Remodeling with Multi-lineage Hypersensitivity to Type I Interferon in Down Syndrome

Cell Reports, 2019
Summary: People with Down syndrome (DS; trisomy 21) display a different disease spectrum relative to the general population, including lower rates of solid malignancies and higher incidence of neurological and autoimmune conditions.
Katherine A. Waugh, Paula Araya, Ahwan Pandey, Kimberly R. Jordan, Keith P. Smith, Ross E. Granrath, Santosh Khanal, Eric T. Butcher, Belinda Enriquez Estrada, Angela L. Rachubinski, Jennifer A. McWilliams, Ross Minter, Tiana Dimasi, Kelley L. Colvin, Dmitry Baturin, Andrew T. Pham, Matthew D. Galbraith, Kyle W. Bartsch, Michael E. Yeager, Christopher C. Porter, Kelly D. Sullivan, Elena W. Hsieh, Joaquin M. Espinosa   +22 more
doaj   +1 more source

In silico modeling guides identification of novel JAK1 variants associated with immune dysregulation. [PDF]

EMBO Mol Med
Jeanpierre M, Debeaupuis O, Brunaud C, Yancoski J, Riller Q, Hadjadj J, Stolzenberg MC, Villarreal G, Katsicas MM, Villa M, Neves JF, Stephan JL, Léonard C, Lazaro E, Ciron J, Boussard C, Mazerolles F, Magerus A, Olivier P, Masson C, Schmitt Y, Hoareau B, Vinit A, Neven B, Quartier P, Isambert H, Oleastro M, Danielian S, Parlato M, Rieux-Laucat F.   +29 more
europepmc   +2 more sources

Epigenetics and immunometabolism in diabetes and aging [PDF]

, 2018
Significance: A strong relationship between hyperglycemia, impaired insulin pathway and cardiovascular disease in type 2 diabetes (T2D) is linked to oxidative stress and inflammation.
Cosentino, Francesco, Guzik, Tomasz J.
core   +2 more sources