Results 221 to 230 of about 241,317 (354)

NKAIN1 expression relates to the immune evasion and prognosis of gastric cancer. [PDF]

Sci Rep
Zhou L, Cheng Y, Liu P, Jin X, Xu Q, Li X.   +5 more
europepmc   +1 more source

Gram-Negative Microflora Dysbiosis Facilitates Tumor Progression and Immune Evasion by Activating the CCL3/CCL5–CCR1–MAPK–PD-L1 Pathway in Esophageal Squamous Cell Carcinoma

Huiqin Yang, Jiahao Cai, Xiao Huang, Cheng Zhan, Chunlai Lu, Jie Gu, Teng Ma, Hongyu Zhang, Tao Cheng, F. Xu, Di Ge   +10 more
openalex   +1 more source

Enzymatic Remodelling of Tumour Microenvironment Enhances Anti‐CEACAM5 CAR T‐Cell Efficacy Against Colorectal Cancer

Advanced Science, EarlyView.
This study shows anti‐CEACAM5 CAR T‐cells are ineffective against colorectal cancer (CRC) because of CEACAM5 sequestration at intercellular junctions and the thick tumour cell glycocalyx. Enzymatic treatments of CRC cell monolayer/tissue section with trypsin or hyaluronidase restore CEACAM5 availability, enhance CAR T‐cell activation, increase ...
Debasis Banik, Christopher J. Ward, Soura Chakraborty, Ziwei Zhang, Daniel Heraghty, Prasanna Suresh, Bing Li, Shekhar Kedia, Jhuma Pramanik, Simon J. Davis, James P. Roy, Michael A. Chapman, Bidesh Mahata, David Klenerman   +13 more
wiley   +1 more source

A Spatiotemporal Model of CXCL10 as a Master Regulator of Immune Evasion and Metastasis in Osteosarcoma. [PDF]

Int J Mol Sci
Gyau BB, Man TK.
europepmc   +1 more source

Lactylation‐Driven YTHDC1 Alleviates MASLD by Suppressing PTPN22‐Mediated Dephosphorylation of NLRP3

Advanced Science, EarlyView.
In MASLD, YTHDC1 undergoes increased lactylation and ubiquitination, reducing its expression. AARS1 mediates lactylation at lysine 565, while disrupted binding to LDHA further promotes lactylation, suppressing YTHDC1. This downregulation enhances PTPN22 mRNA stability, leading to NLRP3 dephosphorylation and activation, which exacerbates inflammation ...
Feng Zhang, Linghua Zeng, Kunkun Zou, Keying Lin, Fangting Yao, Jinglun Song, Shumeng Zhang, Hanshu Feng, Zhichao Yang, Chunlei Wang, Hongtao Diao, Xue Kong, Tengfei Pan, Joonki Kim, Tianqi Duo, Linqiang Li, Yu Bian   +16 more
wiley   +1 more source

PARPi Combining Nanoparticle LIN28B siRNA for the Management of Malignant Ascites

Advanced Science, EarlyView.
This study demonstrates that co‐inhibition of LIN28B and PARP using siLin28b/DSSP@lip‐PEG‐FA nanoparticles in combination with the PARP inhibitor BMN673 effectively suppresses the accumulation of malignant ascites associated with advanced cancers.
Yan Fang, Qian Shen, Yao Lin, Jing Zhu, Xiaolan Zhu, Rui Huang, Yijia Wu, Feiyang Shen, Qian Li, Guopei Zheng, Zhe Zhang, Qian Chu, Junhao Hu, Jianfeng Shen   +13 more
wiley   +1 more source

Glycosylation as a strategic mechanism for measles virus and mumps virus immune evasion. [PDF]

Front Immunol
Galvan C, Ovsyannikova IG, Kennedy RB.
europepmc   +1 more source

Type I Interferon Pathway Activation Disrupts Monocyte Maturation and Enhances Immune Evasion in Multiple Myeloma

Advanced Science, EarlyView.
This study shows that monocytes in multiple myeloma display an excessive interferon response, leading to transcriptional reprogramming and altered differentiation. Using single‐cell sequencing, coculture experiments, and patient samples before and after therapy, the authors demonstrate that induction treatment reduces this interferon response ...
Jian Cui, Jingwei Wang, Xiaoyun Li, Lina Wang, Xuehan Mao, Rui Lyv, Wenqiang Yan, Jingyu Xu, Jieqiong Zhou, Chenxing Du, Shuhui Deng, Mu Hao, Yan Xu, Shuhua Yi, Dehui Zou, Tao Cheng, Xin Gao, Lugui Qiu, Gang An   +18 more
wiley   +1 more source

STING single amino acid polymorphisms modulate iridovirus immune evasion and pathogenicity spectrum. [PDF]

Proc Natl Acad Sci U S A
Qin X, Liang M, Pan W, Zhan Z, Li C, You Y, Weng S, He J, Guo C.   +8 more
europepmc   +1 more source

Supplementary Table S1 from Kindlin-2–Mediated Hematopoiesis Remodeling Regulates Triple-Negative Breast Cancer Immune Evasion [PDF]

Wei Wang, Rahul Chaudhary, Justin Szpendyk, Lamyae El Khalki, Neelum Aziz Yousafzai, E. Ricky Chan, Amar Desai, Khalid Sossey‐Alaoui   +7 more
openalex   +1 more source