Results 261 to 270 of about 241,317 (354)

PBRM1 Deficiency Reshapes an Immune Suppressive Microenvironment Through Epigenetic Tuning of PBRM1‐KDM5C‐IL6 Axis in ccRCC

Advanced Science, EarlyView.
PBRM1 ranks as the second most commonly mutated gene in ccRCC. This study reveals that PBRM1 loss promotes an immunosuppressive microenvironment by elevating M2 TAMs via the KDM5C–IL‐6 axis. These M2 TAMs, along with CAFs, form a barrier that excludes CD8+ T cells. Targeting IL‐6 synergizes with anti‐PD1 therapy, offering a promising strategy for PBRM1‐
Wenjiao Xia, Hongru Wang, Yu Dong, Zitong Yang, Yiyang Zhou, Zhinan Xia, Qinchen Li, Liangliang Ren, Yichun Zheng, Junliang Yan, Dongmei Ma, Zhi Chen, Xingang Cui, Guixin Zhu, Cheng Zhang   +14 more
wiley   +1 more source

Deubiquitinating enzyme JOSD2 modulates cGAS to facilitate immune evasion in colorectal cancer. [PDF]

Oncoimmunology
Du J, Fan Y, Fu J, Ge F, Zhu H, Yang S, Dai J, Yuan T, He Q, Yang B, Zhu H, Dong X.   +11 more
europepmc   +1 more source

Immune Evasion Strategies

, 2018
Aguirre-Garcia, M. Magdalena, Escalona-Montaño, Alma R., Wilkins-Rodríguez, Arturo A., Gutiérrez-Kobeh, Laila   +3 more
openaire   +3 more sources

CLinNET: An Interpretable and Uncertainty‐Aware Deep Learning Framework for Multi‐Modal Clinical Genomics

Advanced Science, EarlyView.
Identifying disease‐causing genes in neurocognitive disorders remains challenging due to variants of uncertain significance. CLinNET employs dual‐branch neural networks integrating Reactome pathways and Gene Ontology terms to provide pathway‐level interpretability of genomic alterations.
Ivan Bakhshayeshi, Mohammad Mahdi Hosseini, Ahmadreza Argha, Roxana Zahedi, Nigel H. Lovell, Hamid Alinejad‐Rokny   +5 more
wiley   +1 more source

The roles of the mtDNA-cGAS-STING axis in tumor immunity: from immune activation to immune evasion. [PDF]

Front Immunol
Huang N, Liu Z, Lei H, Liu X.
europepmc   +1 more source

Disrupting the Formation of YAP Condensates Promotes the Activation of AMPKα to Inhibit the Progression of Primary Liver Cancer

Advanced Science, EarlyView.
This study systematically investigates the function and molecular mechanisms of YAP phase separation in multiple primary liver cancers. These findings provide novel insights into phase separation‐mediated primary liver cancer development and validate targeted disruption of this process as an effective therapeutic strategy for primary liver cancer ...
Shuang‐Zhou Peng, Jia‐Jia Liang, Yun‐Feng Zhan, Wei‐Xun Wu, Wan‐Li Xu, Xiao‐Kun Zhang, Li‐Jun Cai, Fu‐Quan Jiang   +7 more
wiley   +1 more source

Editorial: Targeting cancer-associated fibroblasts: disrupting immune evasion and therapy resistance. [PDF]

Front Immunol
Wang T, Zhou Z, Lu Q.
europepmc   +1 more source

Epstein–Barr Viruses: Their Immune Evasion Strategies and Implications for Autoimmune Diseases [PDF]

Yuehong Zhao, Qi Zhang, Botian Zhang, Yihao Dai, Yifei Gao, Chenzhong Li, Yijing Yu, Conglei Li, Conglei Li, Conglei Li   +9 more
openalex   +1 more source

Stress‐Programmed Immune Niches Fuel TNFR2+ Treg Activation and Drive Neoadjuvant Chemotherapy Resistance in Breast Cancer

Advanced Science, EarlyView.
Single‐cell sequencing reveals stress‐programmed immune states driving TNFα–TNFR2–mediated Treg activation and therapy resistance in breast cancer, while targeting this axis restores antitumor immunity. ABSTRACT The tumor microenvironment (TME) harbors diverse immune cell states that shape therapeutic outcomes in breast cancer.
Zhibo Shao, Xuliren Wang, Han Zhu, Ling Yao, Qi Zhang, Zihan Zhai, Xinyi Lv, Xinyuan Xia, Yi Zhang, Xinya Lu, Xinyi Quan, Jiawen Yang, Xinwei Li, Jieyi Dong, Zhi‐ming Shao, Ruoxi Wang, Bingqiu Xiu, Jiong Wu, Sheng Chen   +18 more
wiley   +1 more source

Network toxicology and multiomics reveal bisphenol A-mediated immune evasion in breast cancer. [PDF]

J Int Med Res
Fang Y, Yan JL, Zhang W.
europepmc   +1 more source