Results 281 to 290 of about 241,317 (354)

Fibrates Inhibit PLTP‐induced M2 Macrophage Infiltration and Increase the Sensitivity of Hepatocellular Carcinoma to ICIs

Advanced Science, EarlyView.
Phospholipid transfer protein(PLTP) plays a critical role in forming a complex with kinase A (AURKA) and P65. This interaction facilitates phosphorylation of P65 at Ser536, leading to the activation of the NF‐κB signaling pathway. Ultimately, this leads to the upregulation of downstream cytokines, including IL‐6, IL‐8, and CSF‐1, which promotes M2 ...
Xinyue Liang, Yaning Li, Jianxun Cai, Lisi Luo, Pengfei Yang, Yutong Chen, Jiancong Zhou, Yan Zeng, Jiaping Yu, Weiyu Zhang, Wenzheng Pang, Yufang Li, Chunhua Wen, Jian Li, Linjuan Zeng   +14 more
wiley   +1 more source

Subtype-specific genetic drivers of immune evasion in breast cancer. [PDF]

Immunooncol Technol
Menyhart O, Győrffy B.
europepmc   +1 more source

Immune Evasion by Staphylococcus aureus: Expanding the Repertoire

, 2018
Nienke W. M. de Jong
openalex   +1 more source

Surface‐Associated Proteins on Extracellular Vesicles Remodel the Tumor Microenvironment by Potentiating TGF‐β Signaling in a Contact‐Dependent Manner

Advanced Science, EarlyView.
Extracellular vesicles (EVs) released from TGF‐β‐activated CAFs are enriched with ECM proteins such as TSG6 and THBS1, which facilitate their binding to recipient cell membranes. This EV–cell interaction promotes the clustering of CD44 and TGF‐β receptors on the target cell surface, thereby potentiating TGF‐β signaling activity. This study highlights a
Chao Li, Agustin Enciso‐Martinez, Lizhe Zhu, Sarah A. Rotman, Peter A. van Veelen, Roman I. Koning, Hailiang Mei, Peter ten Dijke   +7 more
wiley   +1 more source

IGF-1 regulates cancer cell immune evasion in prostate cancer. [PDF]

Sci Rep
Nandakumar AM, Barberis A, Kim J, Lang CR, Mills JV, Rieunier G, Doultsinos D, Taylor A, Jainarayanan A, Phyu SM, Campo L, Easton A, Parkes EE, James T, Hamdy FC, Verrill C, Mills IG, Macaulay VM.   +17 more
europepmc   +1 more source

Cancer Stem Cells Shift Metabolite Acetyl‐Coenzyme A to Abrogate the Differentiation of CD103+ T Cells

Advanced Science, EarlyView.
Lei et al. demonstrate that cancer stem cells (CSCs) play a pivotal role in impairing the differentiation of CD103+ T cells in patients with non‐small‐cell lung cancer. The key mechanism involves CSC‐derived acetyl‐CoA, which disrupts CD103+ T cell differentiation by sequentially inducing acetylation and ubiquitination of the Blimp‐1 protein. Targeting
Jiaxin Lei, Huiyan Ji, Jing Guo, Mengdi Liu, Danhua Su, Yiran Zheng, Lin Xu, Qinghua Cao, Tao Ren, Jun Gui, Zhenke Wen   +10 more
wiley   +1 more source

Epstein-Barr virus functional RNAs as part of its immune evasion strategy: a role for EBER1? [PDF]

Open Biol
Farrell PJ.
europepmc   +1 more source

IL4I1⁺ Macrophages and TDO2⁺ Myofibroblasts Drive AhR‐Mediated Immunosuppression and Ferroptosis Resistance in Solid Predominant Lung Adenocarcinoma

Advanced Science, EarlyView.
Solid predominant lung adenocarcinoma exhibits an immune‐excluded, ferroptosis‐resistant niche enriched with IL4I1⁺ TAMs and TDO2⁺ myCAFs. Spatial and multi‐omics analyses reveal AhR‐driven crosstalk that promotes T cell exhaustion and therapy resistance. Blocking AhR with CH‐223191 restores ferroptosis sensitivity, and its combination with ferroptosis
Zhaoxuan Wang, Weijiao Xu, Lei Zhao, Lin Zhong, Wendan Yu, Shengmin Wang, Lu Sun, Tao Guo, Fengzhou Li, Zhuoshi Li, Lei Fang, Shiqing Wang, Guohui Zhang, Guoqing Xue, Wei Guo, Shilei Zhao, Chundong Gu   +16 more
wiley   +1 more source

Floral stage optimization and immune evasion enhance Agrobacterium-mediated genome editing in Arabidopsis. [PDF]

New Phytol
Liu MS, Huang TK, Wang YC, Wang SC, Wu CH, Kuo CH, Lai EM.   +6 more
europepmc   +1 more source

Data from Prostate Cancer Cells Secrete PD-1 in Exosomes to Enhance Myeloid-Derived Suppressor Cell Activity and Promote Tumor Immune Evasion

Jie Zhang, Weiwu Chen, Chen Zhang, Qian He, Xudong Wang, Jiayu Han, Peng Gao, Kunyu Wang, Hanhui Xie, Feng Gao, Yining Guo, Wenhao Guo, Haofei Jiang, Jing Le, Ruichen Zang, Sisi Mo, Haobo Fan, Xiaoxiao Zhu, Xinrong Jiang, Fengbin Gao, Yanlan Yu, Guoqing Ding, Yicheng Chen   +22 more
openalex   +1 more source