Results 311 to 320 of about 1,940,572 (373)

Single‐Cell and Spatial Transcriptomics Reveals a Stereoscopic Response of Rice Leaf Cells to Magnaporthe oryzae Infection

Advanced Science, EarlyView.
By employing a combination of single cell and spatial transcriptomic sequencing, this study presents a stereoscopic response of rice leaf to Magnaporthe oryzae infection. The vascular tissues mount defenses by producing phytoalexins. The immune strength is stronger toward the rice leaf tip than that of the leaf base.
Wei Wang, Xianyu Zhang, Yong Zhang, Zhe Zhang, Chang Yang, Wen Cao, Yuqin Liang, Qinzheng Zhou, Qian Hu, Yimai Zhang, Yu Wang, Yingying Xing, Wenfeng Qian, Nan Yao, Ning Xu, Jun Liu   +15 more
wiley   +1 more source

The JN.1 variant of COVID-19: immune evasion, transmissibility, and implications for global health. [PDF]

Ther Adv Infect Dis
Naveed Siddiqui A, Musharaf I, Gulumbe BH.   +2 more
europepmc   +1 more source

Natural Enzyme‐Loaded Polymeric Stealth Coating‐Armed Engineered Probiotics by Disrupting Tumor Lactate Homeostasis to Synergistic Metabolism‐Immuno‐Enzyme Dynamic Therapy

Advanced Science, EarlyView.
Engineered Lactobacillus acidophilus (LH@LA) is developed via in situ polymerization to co‐load lactate oxidase (LOx) and horseradish peroxidase (HRP). This system preserves LA activity, evades macrophage phagocytosis, and synergizes LA metabolism with enzyme cascades to enhance immunity, reduce tumor ATP, suppress PD‐L1 expression and AKT‐mTOR ...
Liuzhou Mao, Bahriman Xarpidin, Rui Shi, Yuting Lin, Haohua Hu, Caisheng Wu, Zheng Luo, Yun‐Long Wu   +7 more
wiley   +1 more source

Molecular mimicry as a mechanism of viral immune evasion and autoimmunity. [PDF]

Nat Commun
Maguire C, Wang C, Ramasamy A, Fonken C, Morse B, Lopez N, Wylie D, Melamed E.   +7 more
europepmc   +1 more source

Targeting PFKFB4 Biomimetic Codelivery System Synergistically Enhances Ferroptosis to Suppress Small Cell Lung Cancer and Augments the Efficacy of Anti‐PD‐L1 Immunotherapy

Advanced Science, EarlyView.
In this study, a targeting PFKFB4 biomimetic codelivery system is developed to improve paclitaxel efficacy by inducing ferroptosis in SCLC. This system enhances immune cell infiltration and cytokine secretion, activating anti‐tumor immunity. Combined with anti‐PD‐L1, it boosts immune responses, offering a novel therapeutic strategy for overcoming ...
Xiang Liu, Jingjun He, Haoxuan Ying, Cuiying Chen, Chongyang Zheng, Peng Luo, Weiliang Zhu, Ting Wei, Bufu Tang, Jian Zhang   +9 more
wiley   +1 more source

Histone lactylation-driven B7-H3 expression promotes tumor immune evasion. [PDF]

Theranostics
Ma Z, Yang J, Jia W, Li L, Li Y, Hu J, Luo W, Li R, Ye D, Lan P.   +9 more
europepmc   +1 more source

Locoregional Immune Checkpoint Blockade and Remodeling of Lymph Nodes by Engineered Dendritic Cell‐Derived Exosomes for Suppressing Tumor Progression and Metastasis

Advanced Science, EarlyView.
The study develops engineered exosomes (EmDEX@GA) for locoregional immunomodulation of tumor‐draining lymph node (TDLN). EmDEX@GA can actively target to TDLN and remodel its immunosuppressive microenvironment through the synergistic effects of PD‐1/PD‐L1 blockade and STING pathway activation, subsequently enhance anti‐tumor immunity and suppress tumor ...
Yizhen Wang, Xiaomin Guo, Jingya Qin, Yifan Xue, Peng Zhang, Yadong Liu, Moyang Chen, Guanghao Zhu, Xinqiu Song, Lili Cheng, Bo Liu, Jie Liu, Jie Ren   +12 more
wiley   +1 more source

Rapid Deletion of Antigen-Specific CD4+ T Cells following Infection Represents a Strategy of Immune Evasion and Persistence for Anaplasma marginale

, 2008
Sushan Han, Junzo Norimine, Guy H. Palmer, Waithaka Mwangi, Kevin K. Lahmers, Wendy C. Brown   +5 more
openalex   +1 more source

SARS-CoV-2 serotyping based on spike antigenicity and its implications for host immune evasion. [PDF]

EBioMedicine
Ruan W, Gao P, Qu X, Jiang J, Zhao Z, Qiao S, Zhang H, Yang T, Li D, Du P, Lu X, Wang Q, Zhao X, Gao GF.   +13 more
europepmc   +1 more source

STING Agonists and How to Reach Their Full Potential in Cancer Immunotherapy

Advanced Science, EarlyView.
STING agonists show promise in preclinical studies in boosting an anti‐tumor response using the immune system. However, different limitations remain, and future research is needed to better understand how STING activation impacts the tumor microenvironment, identify effective combination strategies, and determine the best tumor types for STING agonist ...
Laura Gehrcken, Christophe Deben, Evelien Smits, Jonas R.M. Van Audenaerde   +3 more
wiley   +1 more source