Results 91 to 100 of about 7,705,750 (254)

RNA‐related functions of BRCA2 in transcription, replication, and genome stability

FEBS Letters, EarlyView.
Beyond its role in homologous recombination, BRCA2 regulates R‐loop homeostasis, DNA–RNA hybrid resolution, RNA polymerase II dynamics, and transcriptional activation. Disruption of any of these functions can contribute to genome instability, inflammatory signaling, and tumorigenesis. BRCA2 is a central tumor suppressor protein best known for its roles
Lucia Alvaro‐Aranda, Sreerama Chaitanya Sridhara, Aura Carreira   +2 more
wiley   +1 more source

Black Soldier Fly Larvae Meal as a Sustainable Fishmeal Substitute for Juvenile Hybrid Grouper: Impacts on Growth, Immunity, and Gut Health

Fishes
Background: Aquaculture increasingly seeks sustainable alternatives to fishmeal, a key protein source in fish diets. Black Soldier Fly Larvae (BSFL) meal is a promising substitute, but its effects on fish growth, immunity, and gut health need further ...
Yan Chen, Wenfeng Li, Minyi Zhong, Jun Ma, Bing Chen, Junming Cao, Jiun-Yan Loh, Hai Huang   +7 more
doaj   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

The immunomodulatory properties of helminth-derived products on dendritic cell maturation and function [PDF]

, 2009
Parasitic worms and molecules derived from them drive Th2/Treg immune responses in mammalian hosts and have powerful anti-inflammatory properties which are shown to have therapeutic effects on inflammatory diseases.
Dowling, David J.
core   +2 more sources

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Immune Cell Responses to the Cattle Lungworm, Dictyocaulus viviparus [PDF]

, 2008
The cattle lungworm, Dictyocaulus viviparus, is a parasitic nematode, which can cause severe pulmonary disease. Repeated natural infections result in protective immunity, and a live attenuated vaccine exists.
Hagberg, Malin
core   +1 more source

iTRAQ-based quantitative proteomic profiling of the regulatory mechanisms on immune functions and blood lipids in aged mice fed with Lentinula edodes-derived polysaccharides

Food Science and Human Wellness
The mechanisms of mushroom polysaccharides on immune functions and lipid metabolism of aged mammals have not been fully elucidated. In the present study, after assessing the impacts of one type of Lentinula edodes-derived polysaccharides, named L2, on ...
Xiaofei Xu, Xiaofei Liu, Jin Chen, Jingjing Guan, Donghui Luo   +4 more
doaj   +1 more source

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

Amino acid metabolism-mediated immune cell fate and function in pigs

Animal Nutriomics
Amino acids are fundamental to sustaining life. They are crucial for intracellular processes, such as energy metabolism, biosynthesis of nucleotides, and maintenance of oxidative homeostasis.
Liuqin He, Shunshun Jin, Tiejun Li, Yulong Yin   +3 more
doaj   +1 more source

Peripheral Lymphocyte Subsets Absolute Counts as Feasible Clinical Markers for Predicting Surgical Outcome in Gastric Cancer Patients After Laparoscopic D2 Gastrectomy: A Prospective Cohort Study

Journal of Inflammation Research, 2021
Ci Dian Dan Zeng, Yi Xin Tong, Ai Tang Xiao, Chun Gao, Sheng Zhang Department of Gastrointestinal Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People’s Republic of ChinaCorrespondence: Chun Gao ...
Dan Zeng CD, Tong YX, Xiao AT, Gao C, Zhang S   +4 more
doaj