Results 71 to 80 of about 7,705,750 (254)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Artificial Intelligent‐Enhanced Metabolite Profiling for Intraoperative IDH1 Genotyping in Glioma Using an Orthogonally Responsive SERS Probe

Advanced Science
Intraoperative identification of the isocitrate dehydrogenase type 1 (IDH1) genotype, a key molecular marker in glioma, is essential for optimizing surgical strategies and tailoring post‐surgical treatments.
Hang Yin, Xin Zhang, Zheng Zhao, Chong Cao, Minhua Xu, Suhongrui Zhou, Tian Xuan, Ziyi Jin, Limei Han, Yang Fan, Cong Wang, Xiao Zhu, Ying Mao, Jinhua Yu, Cong Li   +14 more
doaj   +1 more source

Research advancements on the diversity and host interaction of gut microbiota in chickens

Frontiers in Veterinary Science
The maintenance of host health and immune function is heavily dependent on the gut microbiota. However, the precise contribution of individual microbial taxa to regulating the overall functionality of the gut microbiome remains inadequately investigated.
Yong Yue, Yong Yue, Pichitpon Luasiri, Pichitpon Luasiri, Jiezhang Li, Phanthipha Laosam, Papungkorn Sangsawad, Papungkorn Sangsawad   +7 more
doaj   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

An Overview of Artificial Immune Systems [PDF]

, 2004
The immune system is highly distributed, highly adaptive, self-organising in nature, maintains a memory of past encounters and has the ability to continually learn about new encounters.
E. Hart, Timmis, Jon, de Castro, Leandro N., L. N. de Castro, Knight, Thomas, Hart, Emma, J. Timmis, T. Knight   +7 more
core   +1 more source

Immune Function in Critically Ill Septic Children

, 2021
The inflammatory response in pediatric sepsis is highly dynamic and includes both pro- and anti-inflammatory elements that involve the innate and adaptive immune systems.
Mark W. Hall, Katherine Elizabeth Bline
core   +1 more source

IMMUNE DYSFUNCTION IN THE ELDERLY: THE ROLE OF NUTRITION

Iranian Journal of Allergy, Asthma and Immunology, 2000
Elderly people experience significantly greater morbidity and mortality from infectious diseases than the general population. This apparent susceptibility to infection in the elderly has been attributed to a decline of immune function with age, termed ...
M.A. I'ahlavani
doaj  

Engineered zwitterion-nanodelivery for precision targeting of brain metastases

Nature Communications
The central nervous system is a critical reservoir for cancer metastasis, underscoring the urgent need for effective strategies for targeted drug delivery that minimize systemic side effects.
Haibao Peng, Youming Zeng, Yang Huang, Chenyu Lin, Zeyu Lei, Peixin Sun, Jiahui Yang, Shaoqi Sheng, Yuxin Huang, Xiaohui Li, Jiaxu Zhao, Rui Zeng, Cheng Li, Wanqi Yang, Xiangjie Di, Sisi He, Yongsheng Wang, Hanting Yang, Wuli Yang, Yudan Chi   +19 more
doaj   +1 more source

Effects of moringa polysaccharides on growth performance, immune function, rumen morphology, and microbial community structure in early-weaned goat kids

Frontiers in Veterinary Science
The aim of this research was to investigate the effects of adding moringa polysaccharides (MOP) on the growth performance, immune function, rumen tissue morphology, and rumen microbial community in early-weaned goat kids.
Jinyang Liu, Jinyu Chen, Sicheng Fang, Baoli Sun, Yaokun Li, Yongqing Guo, Ming Deng, Duoen Zhou, Dewu Liu, Guangbin Liu   +9 more
doaj   +1 more source