Results 51 to 60 of about 1,614,132 (267)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Serum IgA, IgG, IgM levels, total protein (TP), albumin (ALB) changes in elderly hip fracture patients after surgery and nutritional support [PDF]

Journal of Medical Biochemistry
Background: This study aimed to evaluate the effects of nutritional support combined with stratified nursing under delirium risk assessment on immune function and postoperative delirium in elderly hip fracture patients.
Jin Fangqin, Zhang Qin, Weng Jiangping, Pan Xuting, Dong Qinyan, Zhao Yuping   +5 more
doaj   +1 more source

Effects of rare earth-chitosan chelate on growth performance, antioxidative and immune function in broilers

Italian Journal of Animal Science, 2022
This research aims to study the effects of rare earth-chitosan chelates (RECC) on growth performance, immunity and antioxidant function in broilers. A total of 192 one-day-old mixed-sex Arbour Acres (AA) broilers were allotted into 4 treatment groups ...
Yuchen Cheng, Yi Xie, Lulu Shi, Yuanyuan Xing, Shiwei Guo, Yibiao Gao, Zhengya Liu, Sumei Yan, Binlin Shi   +8 more
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Growth, carcase characteristics, meat quality, nutrient digestibility and immune function of broilers fed with enzymatically treated or raw dandelion (taraxacum mongolicum hand.-mazz.)

Italian Journal of Animal Science, 2022
This study aims at evaluating the effects of enzymatically treated or raw dandelion (Taraxacum mongolicum Hand.-Mazz.) on growth performance, carcase characteristics, meat quality, apparent nutrient digestibility, and immunity of Arbour Acres broilers ...
Juan Du, Yang Zhao, Yuan Wang, Mingxin Xie, Ruifang Wang, Na Liu, Xiaoping An, Jingwei Qi   +7 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Spindle neurons in human cortex possess distinctive firing properties and transcriptomic signatures

Nature Communications
Spindle neurons (SPNs), also known as von Economo neurons (VENs), are predominantly found in large-brained species including humans. SPNs in human neocortex are implicated in cognitive functions and affected in various brain disorders.
Wei Ke, Shuxuan Lyu, Mengmeng Jin, Shaoqing Jiao, Liang Li, Heyuan Zhang, Kexin Ling, Cuiping Tian, Yiquan Song, Liu Chen, Quansheng He, Yujie Xiao, Suixin Deng, Liu Fan, Huawei Mu, Hui Yang, Hua-Tai Xu, Hao Wang, Ai-Hui Tang, Jiajie Peng, Jie He, Hui Guo, Yousheng Shu   +22 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Quantitative evaluation of IVL: based on the tunica media gypsum calcification model and a prospective animal study

Frontiers in Cardiovascular Medicine
BackgroundIntravascular lithotripsy (IVL), an emerging adjunctive therapeutic modality, demonstrates potential in managing severely calcified lesions. However, its quantitative efficiency in disrupting calcifications with different characteristics, as ...
Zongwei Liu, Zongwei Liu, Zongwei Liu, Chuang Xu, Chuang Xu, Bin Zhao, Bin Zhao, Jiayin Guo, Jiayin Guo, Jingzhong Song, Jingzhong Song, Jiaxue Bi, Jiaxue Bi, Yujun Shen, Yujun Shen, Yujun Shen, Xiangchen Dai, Xiangchen Dai   +17 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source