Results 61 to 70 of about 7,705,750 (254)

Effects of rare earth-chitosan chelate on growth performance, antioxidative and immune function in broilers

Italian Journal of Animal Science, 2022
This research aims to study the effects of rare earth-chitosan chelates (RECC) on growth performance, immunity and antioxidant function in broilers. A total of 192 one-day-old mixed-sex Arbour Acres (AA) broilers were allotted into 4 treatment groups ...
Yuchen Cheng, Yi Xie, Lulu Shi, Yuanyuan Xing, Shiwei Guo, Yibiao Gao, Zhengya Liu, Sumei Yan, Binlin Shi   +8 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Spindle neurons in human cortex possess distinctive firing properties and transcriptomic signatures

Nature Communications
Spindle neurons (SPNs), also known as von Economo neurons (VENs), are predominantly found in large-brained species including humans. SPNs in human neocortex are implicated in cognitive functions and affected in various brain disorders.
Wei Ke, Shuxuan Lyu, Mengmeng Jin, Shaoqing Jiao, Liang Li, Heyuan Zhang, Kexin Ling, Cuiping Tian, Yiquan Song, Liu Chen, Quansheng He, Yujie Xiao, Suixin Deng, Liu Fan, Huawei Mu, Hui Yang, Hua-Tai Xu, Hao Wang, Ai-Hui Tang, Jiajie Peng, Jie He, Hui Guo, Yousheng Shu   +22 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Quantitative evaluation of IVL: based on the tunica media gypsum calcification model and a prospective animal study

Frontiers in Cardiovascular Medicine
BackgroundIntravascular lithotripsy (IVL), an emerging adjunctive therapeutic modality, demonstrates potential in managing severely calcified lesions. However, its quantitative efficiency in disrupting calcifications with different characteristics, as ...
Zongwei Liu, Zongwei Liu, Zongwei Liu, Chuang Xu, Chuang Xu, Bin Zhao, Bin Zhao, Jiayin Guo, Jiayin Guo, Jingzhong Song, Jingzhong Song, Jiaxue Bi, Jiaxue Bi, Yujun Shen, Yujun Shen, Yujun Shen, Xiangchen Dai, Xiangchen Dai   +17 more
doaj   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Glutathione overproduction mediates lymphoma initiating cells survival and has a sex-dependent effect on lymphomagenesis

Cell Death and Disease
Lymphoid tumor patients often exhibit resistance to standard therapies or experience relapse post-remission. Relapse is driven by Tumor Initiating Cells (TICs), a subset of tumor cells capable of regrowing the tumor and highly resistant to therapy ...
Alberto H.-Alcántara, Omar Kourani, Ana Marcos-Jiménez, Patricia Martínez-Núñez, Estela Herranz-Martín, Patricia Fuentes, María L. Toribio, Cecilia Muñoz-Calleja, Teresa Iglesias, Miguel R. Campanero   +9 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source