Results 111 to 120 of about 128,368 (282)

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Immune mechanisms of protection: can adjuvants rise to the challenge? [PDF]

, 2010
For many diseases vaccines are lacking or only partly effective. Research on protective immunity and adjuvants that generate vigorous immune responses may help generate effective vaccines against such ...
MacLeod Megan KL, Philippa Marrack, Amy S McKee, Marrack, P., Megan KL MacLeod, Marrack Philippa, Kappler, J.W., John W Kappler, MacLeod, M.K.L., Kappler John W, McKee, A.S., McKee Amy S   +11 more
core   +1 more source

Priming of L Cells by Murine Immune Interferon

Intervirology, 1983
Partially purified murine immune interferon (IFN gamma) was found to be equivalent to IFN alpha/beta in its ability to enhance the production of IFN alpha/beta by L-929 cells. While crude preparations were also able to prime, it was apparent that such preparations of IFN contained 'blocking factors' that reduced the priming efficiency of IFN.
S K, Tyring, A D, Luk, S S, Lefkowitz
openaire   +2 more sources

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Immune Priming in A. Mellifera

, 2017
"Trans-generational immune priming (TgIP) is the transfer of maternal immune experience to progeny , producing offspring pathogen resistance and ultimately survival from infections.
Krentz, R. Starling, NC DOCKS at East Carolina University   +1 more
core  

Duration of immune priming and changes in immune parameters following primary and secondary immune challenges in Tenebrio molitor

International audienceThe yellow mealworm (Tenebrio molitor) is a key species in industrial insect farming due to its high nutritional value, low environmental footprint, and efficient feed conversion.
Jehan, Charly, Rigaud, Thierry, Moret, Yannick, Sabarly, Camille   +3 more
core   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Immune Priming in A. Mellifera

, 2018
Trans-generational immune priming (TgIP) is the transfer of maternal immune experience to progeny, producing offspring pathogen resistance and ultimately survival from infections.
Krentz, R. Starling
core  

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Fluorescent imaging of antigen released by a skin-invading helminth reveals differential uptake and activation profiles by antigen presenting cells. [PDF]

, 2009
Infection of the mammalian host by the parasitic helminth Schistosoma mansoni is accompanied by the release of excretory/secretory molecules (ES) from cercariae which aid penetration of the skin.
Ross A Paveley, Ross A. Paveley, Adrian P. Mountford, Aynsley, Sarah A, Sarah A. Aynsley, Cook, Peter C, Adrian P Mountford, Turner, Joseph D, Sarah A Aynsley, Paveley Ross A., Paveley, Ross A, Peter C. Cook, Cook, Peter C; id_orcid, Peter C Cook, Cook Peter C., Mountford Adrian P., Joseph D Turner, Joseph D. Turner, Aynsley Sarah A., Mountford, Adrian P, Turner Joseph D.   +20 more
core   +1 more source