Results 251 to 260 of about 128,368 (282)

Natural Products Inspired Scaffold Diversification Leads to Unnatural Molecular Warhead and Covalent Strategy to Modulating Protein Function through Electrophilic Bromine Transfer

Advanced Science, EarlyView.
We report a new thiolate‐reactive α,α‐gem‐dibromo lactam warhead that activates transcription factor Nrf2 and demonstrates anti‐inflammatory activities, which have implications in cancer, neurodegeneration, and cardiovascular diseases. RNA‐seq illuminated detailed transcriptional profiles, and chemical reactions with cysteine‐containing compounds ...
Beau R. Brummel, Sofia Kokkaliari, Qiwen Gao, Jinjing Chen, Larissa Costa de Almeida, Srinivasarao Tenneti, Derek A. Leas, Eli Levit, Lewis S. Alexander, Khalil A. Abboud, Pingrong Wei, Michael D. Cameron, James R. Rocca, Ranjala Ratnayake, Donna D. Zhang, Hendrik Luesch, Robert W. Huigens III   +16 more
wiley   +1 more source

Modular mechanisms of immune priming and growth inhibition mediated by plant effector-triggered immunity

Chhillar H, Yeh P, Nguyen HH, Jones JD, Ding P.   +4 more
europepmc   +1 more source

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Current understanding of immune priming phenomena in insects

Journal of Invertebrate Pathology, 2021
It may seem that the most important issues related to insect immunity have already been described. However, novel phenomena observed in recent years shed new light on the understanding of the immune response in insects.The adaptive abilities of insects helped them to populate all ecological land niches.One important adaptive ability of insects that ...
Michał Sułek, Jakub Kordaczuk, Iwona Wojda   +2 more
exaly   +3 more sources

Priming Microglia for Innate Immune Memory in the Brain

Trends in Immunology, 2019
Microglia, the resident macrophages of the brain, are highly plastic and well known to be pre-activated or 'primed' by active inflammatory processes, resulting in amplified responses to a second inflammatory insult. Furthermore, the capacity of microglia to develop 'innate immune memory' (IIM), that is, long-lasting molecular reprogramming, has ...
Jonas J Neher, Colm Cunningham
exaly   +4 more sources

Immune regulation of disease tolerance and immune priming in Drosophila [PDF]

, 2022
To regain health following infection, hosts must not only identify and eliminate the source of infection, but also be able to reduce the resulting tissue damage in order to tolerate immunopathology. Compared to the mechanisms of pathogen clearance, we currently know less about how the mechanisms of damage prevention and repair contribute to disease ...
Prakash, Arun
openaire   +4 more sources

Specific immune priming in the invasive ctenophore Mnemiopsis leidyi

Biology Letters, 2013
Specific immune priming enables an induced immune response upon repeated pathogen encounter. As a functional analogue to vertebrate immune memory, such adaptive plasticity has been described, for instance, in insects and crustaceans. However, towards the
Olivia Roth, Philip Rosenstiel, Thorsten B H Reusch   +2 more
exaly   +2 more sources

Priming in Systemic Plant Immunity

Science, 2009
Plants possess inducible systemic defense responses when locally infected by pathogens. Bacterial infection results in the increased accumulation of the mobile metabolite azelaic acid, a nine-carbon dicarboxylic acid, in the vascular sap of Arabidopsis that confers local and systemic ...
Ho Won, Jung, Timothy J, Tschaplinski, Lin, Wang, Jane, Glazebrook, Jean T, Greenberg   +4 more
openaire   +2 more sources

Mechanisms of transgenerational immune priming in insects

Developmental & Comparative Immunology, 2021
Parents invest in their offspring by preparing them for defense against pathogens and parasites that only the parents have encountered, a phenomenon known as transgenerational immune priming (TGIP). The priming effect can be passed maternally or paternally to the next generation, thus increasing the survival of offspring exposed to the same pathogen ...
openaire   +2 more sources

Specificity of oral immune priming in the red flour beetle Tribolium castaneum

Biology Letters, 2017
Immune specificity is the degree to which a host's immune system discriminates among various pathogens or antigenic variants. Vertebrate immune memory is highly specific due to antibody responses. On the other hand, some invertebrates show immune priming,
Megan A M Kutzer, Joachim Kurtz
exaly   +4 more sources

Immune Priming of the Tumor Microenvironment by Radiation

Trends in Cancer, 2016
Ionizing irradiation can induce a multitude of alterations within the tumor microenvironment. Unlike targeted therapies, radiation delivered to the tumor bed can prompt phenotypic changes in both normal stromal and cancer cells, leading to molecular and physiological alterations within the tumor microenvironment.
Wen, Jiang, Charles K, Chan, Irving L, Weissman, Betty Y S, Kim, Stephen M, Hahn   +4 more
openaire   +2 more sources