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Mechanisms of transgenerational immune priming in insects
Developmental & Comparative Immunology, 2021Parents invest in their offspring by preparing them for defense against pathogens and parasites that only the parents have encountered, a phenomenon known as transgenerational immune priming (TGIP). The priming effect can be passed maternally or paternally to the next generation, thus increasing the survival of offspring exposed to the same pathogen ...
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Male Pregnancy and Biparental Immune Priming
The American Naturalist, 2012In vertebrates, maternal transfer of immunity via the eggs or placenta provides offspring with crucial information on prevailing pathogens and parasites. Males contribute little to such transgenerational immune priming, either because they do not share the environment and parasite pressure of the offspring or because sperm are too small for transfer of
Olivia, Roth +4 more
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Immune Priming of the Tumor Microenvironment by Radiation
Trends in Cancer, 2016Ionizing irradiation can induce a multitude of alterations within the tumor microenvironment. Unlike targeted therapies, radiation delivered to the tumor bed can prompt phenotypic changes in both normal stromal and cancer cells, leading to molecular and physiological alterations within the tumor microenvironment.
Wen, Jiang +4 more
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Immune priming: An overview in insects
Insect Environment, 2022A characteristics feature of living systems is the ability to provide protection from different kinds of infection and various toxins. Importantly in insects, innate immune response is the most fascinating phenomenon. Though vertebrates' specific adaptive immune system is lacking in invertebrates including insects, defence priming is integral to many ...
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Meningeal lymphatics prime tumor immunity in glioblastoma
Cancer Cell, 2021The notion of the brain as an immune-privileged organ has been challenged by the discovery of functional lymphatic vessels in the meninges of the dorsal and basal skull. A study published in Nature in 2020 shows that meningeal lymphatics play an important role in the sensing of brain tumor antigens.
Maya S, Graham, Ingo K, Mellinghoff
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Priming Microglia for Innate Immune Memory in the Brain
Trends in Immunology, 2019Microglia, the resident macrophages of the brain, are highly plastic and well known to be pre-activated or 'primed' by active inflammatory processes, resulting in amplified responses to a second inflammatory insult. Furthermore, the capacity of microglia to develop 'innate immune memory' (IIM), that is, long-lasting molecular reprogramming, has ...
Jonas Neher, Colm Cunningham
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Stimulation of Primed Neutrophils by Soluble Immune Complexes
Biologicals, 1996Soluble IgG-containing immune complexes are unable to initiate oxidant production in unprimed neutrophils. However, priming of the neutrophils with either granulocyte-macrophage colony-stimulating factor (GM-CSF) or cytochalasin B prior to exposure to these complexes results in activation of a rapid and extensive secretion of reactive oxidants. In this
F, Watson, S W, Edwards
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Priming and expression of immune responses in the gastric mucosa
Microbes and Infection, 2003This review deals with the induction and expression of immune responses in the human stomach following mucosal immunisation. As prerequisites for developing a Helicobacter pylori vaccine, the role of gastric inflammation, in particular inflammation induced by H. pylori infection, as well as lymphocyte homing within the common mucosal immune system, and
Ann-Mari, Svennerholm +1 more
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Priming of the immune response by schistosome eggs
Parasite Immunology, 2005SUMMARY Schistosomiasis mansoni is a chronic disease caused by infection with helminths of the genus Schistosoma mansoni. Adult schistosomes live intravascularly, and for transmission of this infection it is necessary for parasite eggs to traverse the endothelium, and migrate to the intestinal lumen, from where they can exit the body to continue the ...
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Danger, diversity and priming in innate antiviral immunity
Cytokine & Growth Factor Reviews, 2014The prototypic response to viral infection involves the recognition of pathogen-associated molecular patterns (PAMPs) by pattern recognition receptors (PRRs), leading to the activation of transcription factors such as IRF3 and NFkB and production of type 1 IFN. While this response can lead to the induction of hundreds of IFN-stimulated genes (ISGs) and
Susan E. Collins, Karen L. Mossman
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