Results 181 to 190 of about 2,306,505 (335)

Targeting ANGPTL3 and IL‐33/ST2 Ameliorates Diabetic Kidney Disease by Reducing Lipotoxicity, Alleviating Inflammation and Inhibiting Fibrosis

Advanced Science, EarlyView.
Dual targeting of ANGPTL3 and IL‐33/ST2 attenuates diabetic kidney disease by reprogramming lipid–inflammatory crosstalk. This strategy reduces renal lipotoxicity, suppresses inflammatory activation, and limits fibrotic remodeling, thereby preserving kidney structure and function and highlighting a mechanism‐guided therapeutic approach for metabolic ...
Zhuojin Li, Zhonglian Cao, Rongrui Zhou, Xu Cheng, Xiaozhi Hu, Shuwen Xu, Zihan Dou, Ling Du, Dianwen Ju   +8 more
wiley   +1 more source

Tegumentary Leishmaniasis Associated With Immune Reconstitution in an HIV Patient-A Case Report. [PDF]

Parasite Immunol
Xavier MB, Gomes CMC, Sousa RCM, Ishikawa EAY, Brito EB, Müller SFR, Fontes LDS, Brito JAGSM, Alcantara LDS, Corbett CEP.   +9 more
europepmc   +1 more source

Bandgap‐Engineered PtxTey:Ag2Te Composite Quantum Dots Enable Programmable NIR‐II Imaging and Photothermal‐Immune Synergistic Therapy

Advanced Science, EarlyView.
A bandgap‐engineered PtxTey:Ag2Te quantum dot platform enables tunable NIR‐IIb emission for deep‐tissue imaging and mild photothermal therapy. Conjugation with αPD‐L1 confers dual tumor targeting and real‐time monitoring of PD‐L1 dynamics. Mild photothermal modulation induces immune reprogramming, enhancing checkpoint blockade efficacy and achieving ...
Jing Liu, Rui Xu, Quan Wu, Tian‐Xin Xiao, Lai‐Xi Zhao, Lei Sun, Ya‐Wen Zheng, Liang Dong, Zhi‐Quan Tian, Haibo Wang   +9 more
wiley   +1 more source

Novel genetic variants in tuberculosis-associated immune reconstitution inflammatory syndrome. [PDF]

Am J Respir Crit Care Med
Wieder C, Horswell S, Kelly G, Stek C, Moseki R, Rossi-Smith P, Ebbels TMD, Wilkinson RJ, Meintjes G, Lai RPJ.   +9 more
europepmc   +1 more source

Immune reconstitution and survival of 100 SCID patients post-hematopoietic cell transplant: a PIDTC natural history study.

Blood, 2017
J. Heimall, B. Logan, M. Cowan, L. Notarangelo, Linda M Griffith, J. Puck, D. Kohn, M. Pulsipher, S. Parikh, C. Martinez, N. Kapoor, R. O'reilly, M. Boyer, S. Pai, F. Goldman, L. Burroughs, S. Chandra, M. Kletzel, Monica S. Thakar, J. Connelly, G. Cuvelier, B. D. Dávila Saldaña, E. Shereck, A. Knutsen, K. Sullivan, K. Desantes, A. Gillio, E. Haddad, A. Petrovič, Troy C. Quigg, Angela R. Smith, Elizabeth Stenger, Z. Yin, W. Shearer, T. Fleisher, R. Buckley, C. Dvorak   +36 more
semanticscholar   +1 more source

Nucleic Acid Therapeutics for “Undruggable” Cancer Targets: Mechanisms, Challenges, and Prospects

Advanced Science, EarlyView.
Nucleic acid therapeutics bypass the structural limitations of conventional drugs by targeting mRNA rather than proteins. This review examines how antisense oligonucleotides, siRNAs, miRNAs, aptamers, and mRNA vaccines intervene against historically undruggable oncoproteins including Ras, MYC, and p53, highlighting mechanistic advances, delivery ...
Feng Xu, Ke Wang, Kaizhong Lu, Tianlun Hou, Yuan Chen, Xian Wang, Hongchuan Jin   +6 more
wiley   +1 more source

VLA-4 agonist promotes engraftment and immune reconstitution of allogeneic hematopoietic stem cells. [PDF]

Blood Adv
He Q, Sun X, Chen LV, Yang J, Gao Y, Wan L, Cai Y, Zhou X, Shen L, Jiang P, Liu J, Ding X, Li L, Tong Y, Qiu H, Huang C, Dong B, Zhou K, Yang Y, Wang P, Liang X, Zhang Y, Zhou BO, Zhang F, Song X.   +24 more
europepmc   +1 more source

Immune reconstitution post bone marrow transplantation

, 2000
Bibliography: leaves 82-95.The aims of this project were therefore: to document the immune reconstitution following T-cell depleted bone marrow and peripheral blood stem cell transplantation and to compare this with the recovery following autologous ...
Davison, Glenda Mary
core  

IKKβ and USP28 Regulate HEY1 Stability to Promote Cancer Stemness and Immune Evasion in Hepatocellular Carcinoma

Advanced Science, EarlyView.
The uncovered IKKβ‐USP28‐HEY1 axis fuels cancer stemness and immune evasion in hepatocellular carcinoma. USP28 deubiquitinates HEY1 upon IKKβ‐mediated phosphorylation, conferring PD‐1/PD‐L1 blockade resistance. Pharmacological inhibition of USP28 sensitizes resistant tumors to anti‐PD‐1 immunotherapy, revealing a promising therapeutic strategy ...
Na Shao, Lin Zhang, Gufang Shen, Yangfan Lv, Tianshu Fang, Ya Cao, Qiongyi Zhang, Feng Xu, Chungang Liu   +8 more
wiley   +1 more source

Dynamic Immune Reconstitution and Clinical Outcomes of Three Different Protocols for Haploidentical Hematopoietic Stem Cell Transplantation. [PDF]

MedComm (2020)
Ma XD, Ji J, Xu ZL, Xu LP, Wang Y, Zhang XH, Sun YQ, Mo XD, Cheng YF, Guo HD, Dong T, Huang XJ.   +11 more
europepmc   +1 more source