Results 191 to 200 of about 1,305,369 (291)

Dynamic Immune Reconstitution and Clinical Outcomes of Three Different Protocols for Haploidentical Hematopoietic Stem Cell Transplantation. [PDF]

MedComm (2020)
Ma XD, Ji J, Xu ZL, Xu LP, Wang Y, Zhang XH, Sun YQ, Mo XD, Cheng YF, Guo HD, Dong T, Huang XJ.   +11 more
europepmc   +1 more source

USP4‐Dependent CHAF1B Stabilization Regulates Distinct SETDB1 Ubiquitin States Linked to AKT T308 Signaling and Lipogenic Remodeling in HCC

Advanced Science, EarlyView.
USP4 stabilizes CHAF1B by limiting K48‐linked ubiquitination. Stabilized CHAF1B supports UHRF1‐associated K63‐linked SETDB1 ubiquitination and cytoplasmic redistribution, whereas CHAF1B loss favors VHL‐dependent K11‐associated degradative ubiquitination and proteasomal loss of SETDB1.
Saiyan Bian, Yun Tong, Wenkai Ni, Zhangzhi Tang, Weiting Chen, Kexin Ma, Lihan Jiang, Jiayu Shao, Xuyang He, Wenjie Zheng   +9 more
wiley   +1 more source

Impact of post-transplant cyclophosphamide and anti-thymocyte globulin on immune reconstitution in MUD allo-HCT. [PDF]

Front Immunol
Furnari G, Wais V, Francesio A, Strauss K, Piemontese S, Schnell J, Gianni P, Greco R, Stegelmann F, Ruggeri A, Assanelli A, Bunjes D, Ciceri F, Döhner H, Lupo-Stanghellini MT, Sala E.   +15 more
europepmc   +1 more source

Mitochondrial Protection and Neural Repair via ROS‐Responsive Biomimetic Nanoparticles in Intracerebral Hemorrhage

Advanced Science, EarlyView.
A ROS‐responsive biomimetic nanoparticle platform co‐delivers DIDS and Mdivi‐1 to protect mitochondria and promote neural repair after intracerebral hemorrhage. By targeting LPAR1/VDAC1‐related mitochondrial dysfunction, the nanotherapy reduces oxidative injury, neuronal apoptosis, and blood‐brain barrier disruption, improving neurological recovery and
Ling Gao, Li Peng, Xiaobin Zheng, Cong Tan, Chuang Wang, Qijiang Xiong, Weiming Chen, Zhao Yang   +7 more
wiley   +1 more source

Torque Teno Virus (TTV) Viremia as a Biomarker of Immune Reconstitution and Outcomes in Pediatric Allogeneic Hematopoietic Stem Cell Transplantation. [PDF]

J Med Virol
Mozo Y, Del Rosal T, Falces-Romero I, Al-Akioui Sanz K, Atucha J, Pertiñez L, Losantos I, Moreno Hidalgo MÁ, Balas A, Vicario JL, Díez-Picazo C, Cid M, Sisinni L, Bueno D, Corral Sánchez D, Olivas-Mazón R, Bravo-Gallego LY, Sánchez-Zapardiel E, López-Granados E, Sainz T, Calvo C, Pérez-Martínez A.   +21 more
europepmc   +1 more source

NCOA4 Accelerates Abdominal Aortic Aneurysm Formation by Regulating Macrophage Activation and Ferroptosis via STAT1–CH25H Axis

Advanced Science, EarlyView.
Under pathological stimulation, NCOA4 in macrophages interacts with STAT1 to promote CH25H transcription. The subsequent increase in 25‐HC production activates macrophages, triggers inflammatory responses and ferroptosis, and accelerates the progression of AAA.
Zhinan Wu, Yuxuan Qian, Wenyi Xu, Fei Liao, Xueliang Liu, Xiao Kuang, Guqing Luo, Xinjie He, Lixian Jiang, Song Ding   +9 more
wiley   +1 more source

Mpox in a 49-year-old man with possible immune reconstitution inflammatory syndrome. [PDF]

CMAJ
Goto T, Maruno M, Sakamoto N.
europepmc   +1 more source

Decoding Biomolecular Phase Separation: From Physiological Roles to Pathological Mechanisms and Therapeutic Biomaterials Design

Advanced Science, EarlyView.
This review systematically elaborates on the mechanisms underlying physiological regulation and pathological dysregulation of biomolecular phase separation. It also summarizes advances in phase‑separation‑targeted therapeutic strategies and the design of functional biomaterials inspired by this process.
Jiawei Zhu, Jingbo Dong, Qiufang Gong, Xuejiao Song, Zhifa Shen, Chao Liang   +5 more
wiley   +1 more source

Co-receptor usage in distinct phylogenetic clusters of HIV-1 CRF01_AE is associated with differential immune reconstitution after antiretroviral therapy. [PDF]

Microbiol Spectr
Liu Y, Lu J, Qiu T, Hu Z, Li W, Li X, Du G, Zhao M, Ma H, Wei P, Yang D, Ge Y.   +11 more
europepmc   +1 more source

CD112 Lactylation Drives Dual Immune Evasion From CD8+ T Cells and NK Cells

Advanced Science, EarlyView.
AARS2 functions as an intracellular lactate sensor and lactyltransferase, catalyzing CD112 K412 lactylation to block ubiquitination‐dependent degradation and stabilize CD112. This pathway suppresses CD8+ T‐cell and NK‐cell cytotoxicity, enabling dual immune evasion.
Zhuoshuo Xu, Xinyu Zhang, Fang Dong, Nenghao Shen, Jun Zhou, Zihan Xi, Zhenghao Wu   +6 more
wiley   +1 more source