Results 51 to 60 of about 128,938 (315)

Inhibitor of DNA binding‐1 is a key regulator of cancer cell vasculogenic mimicry

Molecular Oncology, EarlyView.
Elevated expression of transcriptional regulator inhibitor of DNA binding 1 (ID1) promoted cancer cell‐mediated vasculogenic mimicry (VM) through regulation of pro‐angiogenic and pro‐cancerous genes (e.g. VE‐cadherin (CDH5), TIE2, MMP9, DKK1). Higher ID1 expression also increased metastases to the lung and the liver.
Emma J. Thompson, Emma L. Dorward, Kristyn Jurrius, Nathalie Nataren, Markus Tondl, Kay K. Myo Min, Michaelia P. Cockshell, Anahita Fouladzadeh, John Toubia, Mark DeNichilo, Delphine Merino, Claudine S. Bonder   +11 more
wiley   +1 more source

Regulation of Gut Microbiota on Immune Reconstitution in Patients With Acquired Immunodeficiency Syndrome

Frontiers in Microbiology, 2020
Human immunodeficiency virus type 1 (HIV-1) infection of CD4+ T cells in the gut plays an insidious role in acquired immunodeficiency syndrome (AIDS) pathogenesis. Host immune function is closely related to gut microbiota.
Shi-Tao Geng, Shi-Tao Geng, Shi-Tao Geng, Zun-Yue Zhang, Zun-Yue Zhang, Yue-Xin Wang, Yue-Xin Wang, Yue-Xin Wang, Danfeng Lu, Danfeng Lu, Juehua Yu, Juehua Yu, Jian-Bo Zhang, Yi-Qun Kuang, Yi-Qun Kuang, Kun-Hua Wang, Kun-Hua Wang, Kun-Hua Wang   +17 more
doaj   +1 more source

Reconstitution of hepatitis B virus (HBV)-specific T cell responses with treatment of human immunodeficiency virus/HBV coinfection [PDF]

, 2003
Liver-related mortality is an increasing problem in human immunodeficiency virus (HIV)/hepatitis B virus (HBV)-coinfected patients receiving highly active antiretroviral therapy (HAART).
Bertoletti, A, Gilson, RJ, Lascar, RM, Lopes, AR, Maini, MK   +4 more
core   +1 more source

MIF as an oncogenic driver of low‐heterogeneity melanomas

Molecular Oncology, EarlyView.
Shvefel and colleagues identified tumor‐secreted macrophage migration inhibitory factor (MIF) as an upregulated cytokine that mediates immune resistance in melanomas with low‐intratumoral heterogeneity. MIF and its functional paralogue D‐dopachrome tautomerase (D‐DT or MIF‐2) have overlapping but nonidentical signaling functions and are hypothesized to
Thuy T. Tran, Gabriela Athziri Sánchez‐Zuno, Rajan P. Kulkarni, Harriet M. Kluger, Richard Bucala   +4 more
wiley   +1 more source

Role of reduced intensity conditioning in T-cell and B-cell immune reconstitution after HLA-identical bone marrow transplantation in ADA-SCID

Haematologica, 2010
The treatment of choice for severe combined immunodeficiency is bone marrow transplantation from an HLA-identical donor sibling without conditioning.
Caterina Cancrini, Francesca Ferrua, Alessia Scarselli, Immacolata Brigida, Maria Luisa Romiti, Graziano Barera, Andrea Finocchi, Maria Grazia Roncarolo, Maurizio Caniglia, Alessandro Aiuti   +9 more
doaj   +1 more source

Thymus transplantation for complete DiGeorge syndrome: European experience [PDF]

, 2017
Background: Thymus transplantation is a promising strategy for the treatment of athymic complete DiGeorge syndrome (cDGS). Methods: Twelve patients with cDGS were transplanted with allogeneic cultured thymus.
Adrian J. Thrasher, Alina Papadopol, Amrolia, Anderson, Anna Furmanski, Austen Worth, Blythe Devlin, David M. Sansom, Davies, Despina Moshous, E. Graham Davies, Elizabeth McCarthy, Furmanski, H. Bobby Gaspar, Hans Christian Erichsen, Hassan, Hassan, Heino, Ida Ricciardelli, Janda, Jesmeen Maimaris, Joe Curry, Jolanta Bernatoniene, Kathryn L. Parsley, Kim Neuling, Kimberly Gilmour, King, Konstantinos Mengrelis, Lizzie Hutchison, Luigi Poliani, M. Louise Markert, Malgorzata Pac, Marianne Ifversen, Markert, Markert, Markert, Markert, Markert, Markert, Markert, McGhee, Melissa Cheung, Michael Browning, Morbach, Morbach, Neil Halliday, Neil Sebire, Poliani, Ronald Bremner, Rucci, Ryan, Schubert, Shearer, Shearer, Stuart Adams, T. Ronan Leahy, Tessa Crompton, Tiia Voor, Winnie Ip, Yang   +59 more
core   +2 more sources

CINs of the cytoplasm: dissecting dsRNA signaling in chromosomal instability

Molecular Oncology, EarlyView.
Micronuclei, formed during cell division in chromosomal instability settings, rupture and lead to the accumulation of immunogenic double‐stranded RNA in the cytoplasm, activating MAVS‐dependent interferon signaling and innate antitumor immunity.
Aglaia Skolariki, Rose L. Jady‐Clark, Eileen E. Parkes   +2 more
wiley   +1 more source

The immune reconstitution inflammatory syndrome

Indian Journal of Dermatology, 2011
A paradoxical clinical worsening of a known condition or the appearance of a new condition after initiating antiretroviral therapy in HIV-infected patients is defined as immune reconstitution inflammatory syndrome (IRIS).
Sanjay S Bosamiya
doaj   +1 more source

Comparative study of adenosine 3′‐pyrophosphokinase domains of MuF polymorphic toxins

FEBS Open Bio, EarlyView.
With the ultimate goal of understanding the association of toxin‐immunity modules to temperate phages, we characterized toxins from three prophages and examined cross‐protection from immunity proteins. The toxins exhibit adenosine 3′‐pyrophosphokinase activity and are toxic in Escherichia coli.
Eloïse M. Paulet, Julia Bartoli, Atakan Kabtan, Chloé M. Piras, Audrey C. Tempier, Eric Cascales, Julie P. Viala   +6 more
wiley   +1 more source

Phase Transition in Reconstituted Chromatin [PDF]

Europhysics Letters, Vol. 69, Iss. 6, pp. 1024-1030 (2005), 2004
By observing reconstituted chromatin by fluorescence microscopy (FM) and atomic force microscopy (AFM), we found that the density of nucleosomes exhibits a bimodal profile, i.e., there is a large transition between the dense and dispersed states in reconstituted chromatin. Based on an analysis of the spatial distribution of nucleosome cores, we deduced
arxiv   +1 more source