Results 41 to 50 of about 1,305,369 (291)

Immune reconstitution inflammatory syndrome

Indian Journal of Dermatology, Venereology and Leprology, 2008
Immune reconstitution inflammatory syndrome (IRIS) is a paradoxical deterioration in clinical status in a patient on antiretroviral treatment (ART) despite satisfactory control of viral replication and improvement of CD4 count.To study development of IRIS as a part of ART.Hundred patients on antiretroviral treatment were studied prospectively in the ...
Sharma, Ajay, Makrandi, Smita, Modi, Megha, Sharma, Archana, Marfatia, Yogesh   +4 more
openaire   +2 more sources

Immune reconstitution syndrome in HIV: validating a case definition and identifying clinical predictors in persons initiating antiretroviral therapy

, 2006
Background: Clinical deterioration after initiation of antiretroviral therapy may result from restored immunity. There is no standard clinical definition for immune reconstitution syndrome.
Wall, Jennifer, Ying, Jun, Robertson, Jaime, Fichtenbaum, Carl J., Meier, Matthew   +4 more
core   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Immune Reconstitution Bone Loss Exacerbates Bone Degeneration Due to Natural Aging in a Mouse Model( ) [PDF]

, 2021
BACKGROUND: Immune reconstitution bone loss (IRBL) is a common side-effect of antiretroviral therapy (ART) in people with human immunodeficiency virus (PWH).
Weitzmann, M Neale, McGee-Lawrence, Meghan E, Weiss, Daiana, Yu, Kanglun, Chang, Wenhan, Vikulina, Tatyana, Ofotokun, Ighovwerha, Tu, Chia Ling, Roser-Page, Susanne, Meghan E McGee-Lawrence, Kanglun Yu, Ighovwerha Ofotokun, Susanne Roser-Page, M Neale Weitzmann, Daiana Weiss, Chia Ling Tu, Tatyana Vikulina, Wenhan Chang   +17 more
core   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

Incomplete Immune Recovery in HIV Infection: Mechanisms, Relevance for Clinical Care, and Possible Solutions

Clinical and Developmental Immunology, 2012
Treatment of HIV-infected patients with highly active antiretroviral therapy (HAART) usually results in diminished viral replication, increasing CD4+ cell counts, a reversal of most immunological disturbances, and a reduction in risk of morbidity and ...
Julie C. Gaardbo, Hans J. Hartling, Jan Gerstoft, Susanne D. Nielsen   +3 more
doaj   +1 more source

Demodicosis revealing an HIV infection

New Microbes and New Infections, 2019
We report an observation of facial and upper limb demodicosis, revealing a human immunodeficiency virus infection. After an initial improvement with metronidazole, worsening of skin lesions related to immune reconstitution inflammatory syndrome was ...
W. Hachfi, D. Slama, N. Ben Lasfar, K. Mnif, F. Bellazreg, A. Fathallah, A. Letaief   +6 more
doaj   +1 more source

Comparative characteristics of patients presented with unmasking and paradoxical immune-reconstitution syndrome, and patients other than those who presented with unmasking immune-reconstitution syndrome.

, 2016
Comparative characteristics of patients presented with unmasking and paradoxical immune-reconstitution syndrome, and patients other than those who presented with unmasking immune-reconstitution syndrome.
Takahiro Aoki (212477), Tetsuro Kobayashi (308002), Takeshi Nishijima (212471), Yoshimi Kikuchi (212497), Hiroyuki Gatanaga (205448), Katsuji Teruya (212494), Shinichi Oka (205454)   +6 more
core   +1 more source

“Chronic Disseminated Aspergillosis,” a Novel Fungal Immune Reconstitution Inflammatory Syndrome

, 2020
International audienceWe report a case of chronic hepatosplenic aspergillosis following immune reconstitution complicating colic aspergillosis in an AIDS patient with multicentric Castleman disease.
Mira, Jean-Paul, Olivier Lortholary, Estelle Blanc, Marthe Weinandt, Gregory Jouvion, Blanc, Estelle, Boutboul, David, Romain Guery, Rouquette, Alexandre, Lortholary, Olivier, Julie Bruneau, Jouvion, Gregory, Bruneau, Julie, Lecuit, Marc, Rouzaud, Claire, Claire Rouzaud, David Boutboul, Thierry Jo Molina, Pourbaix, Annabelle, Weinandt, Marthe, Guery, Romain, Jérémy Lourenço, Marc Lecuit, Jean-Paul Mira, Lourenço, Jérémy, Alexandre Rouquette, Annabelle Pourbaix, Molina, Thierry Jo   +27 more
core   +1 more source