Results 21 to 30 of about 75,329 (259)

Post-transplant cyclophosphamide alters immune signatures and leads to impaired T cell reconstitution in allogeneic hematopoietic stem cell transplant

Journal of Hematology & Oncology, 2022
Despite the increased usage of post-transplant cyclophosphamide (PTCy) in allogeneic hematopoietic stem cell transplantation (allo-HSCT), our knowledge of immune reconstitution post-allo-HSCT in the setting of PTCy is limited.
Chenchen Zhao, Matthew Bartock, Bei Jia, Neal Shah, David F. Claxton, Baldeep Wirk, Kevin L. Rakszawski, Myles S. Nickolich, Seema G. Naik, Witold B. Rybka, W Christopher C. Ehmann, Raymond J. Hohl, Jessica Valentin, Michelle Bernas-Peterson, Emily M. Gerber, Michele Zimmerman, Joseph A. Mierski, Shin Mineishi, Hong Zheng   +18 more
doaj   +1 more source

Immune reconstitution inflammatory syndrome

Indian Journal of Dermatology, Venereology and Leprology, 2008
Immune reconstitution inflammatory syndrome (IRIS) is a paradoxical deterioration in clinical status in a patient on antiretroviral treatment (ART) despite satisfactory control of viral replication and improvement of CD4 count.To study development of IRIS as a part of ART.Hundred patients on antiretroviral treatment were studied prospectively in the ...
Sharma, Ajay, Makrandi, Smita, Modi, Megha, Sharma, Archana, Marfatia, Yogesh   +4 more
openaire   +2 more sources

Rebooting immunity in congenital athymia: Factors impacting reconstitution with thymus implantationFactors impacting reconstitution with thymus implantation [PDF]

Journal of Human Immunity
Allogeneic processed thymus tissue-agdc (RETHYMIC) is approved therapy for treatment of congenital athymia. Study outcomes include changes in T lymphocyte subsets and T cell function.
Samantha Cresoe-Ortiz, Guglielmo Venturi, Elizabeth A. McCarthy, Benjamin Stewart-Bates, Jennifer R. Heimall, Eveline Y. Wu, John W. Sleasman, Geoffrey Hall   +7 more
doaj   +1 more source

Mass Cytometry for the Assessment of Immune Reconstitution After Hematopoietic Stem Cell Transplantation

Frontiers in Immunology, 2018
Mass cytometry, or Cytometry by Time-Of-Flight, is a powerful new platform for high-dimensional single-cell analysis of the immune system. It enables the simultaneous measurement of over 40 markers on individual cells through the use of monoclonal ...
Lauren Stern, Lauren Stern, Lauren Stern, Helen McGuire, Helen McGuire, Helen McGuire, Helen McGuire, Selmir Avdic, Selmir Avdic, Selmir Avdic, Simone Rizzetto, Barbara Fazekas de St Groth, Barbara Fazekas de St Groth, Barbara Fazekas de St Groth, Barbara Fazekas de St Groth, Fabio Luciani, Barry Slobedman, Barry Slobedman, Barry Slobedman, Emily Blyth, Emily Blyth, Emily Blyth, Emily Blyth   +22 more
doaj   +1 more source

Natural Killer Cells in Paediatric Soft Tissue Sarcomas: A Systematic Review

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Paediatric soft tissue sarcomas (pSTS) are a rare and heterogeneous group of malignant tumours arising in tissues of mesenchymal origin. The role of natural killer (NK) cells in pSTS remains poorly understood, with evidence fragmented across small preclinical studies and early‐phase clinical trials.
Raya Dean, Lara V. Graham, Christina Putnam, Rosa Gomes Alves Martins, Daniel T. Harding, Tim J. Underwood, Zoë S. Walters, Matthew D. Blunt   +7 more
wiley   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Demodicosis revealing an HIV infection

New Microbes and New Infections, 2019
We report an observation of facial and upper limb demodicosis, revealing a human immunodeficiency virus infection. After an initial improvement with metronidazole, worsening of skin lesions related to immune reconstitution inflammatory syndrome was ...
W. Hachfi, D. Slama, N. Ben Lasfar, K. Mnif, F. Bellazreg, A. Fathallah, A. Letaief   +6 more
doaj   +1 more source

Opportunities and Obstacles Associated With Sequential Immune Reconstitution Therapy for Multiple Sclerosis: A Case Report

Frontiers in Neurology, 2021
Cladribine is an effective disease-modifying treatment for relapsing-remitting multiple sclerosis that acts as an immune reconstitution therapy and is administered in a pulsed manner.
Riccardo Garbo, Daniela Cutuli, Simone Lorenzut, Gian Luigi Gigli, Gian Luigi Gigli, Daniele Bagatto, Mariarosaria Valente, Mariarosaria Valente   +7 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source