Results 1 to 10 of about 80,115 (117)

Nutritional and hematological determinants of immune reconstitution and development of a predictive model among virologically suppressed people living with HIV [PDF]

Frontiers in Nutrition
BackgroundDespite effective viral suppression achieved through antiretroviral therapy (ART), a substantial proportion of people living with HIV (PLWH) fail to achieve adequate immune reconstitution and remain at increased risk of adverse clinical ...
Ke Xin, Ke Xin, Lijing Wang, Yuxin Feng, Jianhua Lu, Xiaojing Qu, Yingxia Li, Xingyi Yao, Beilei Li, Erhei Dai, Yuling Wang, Huixia Gao, Huixia Gao   +12 more
doaj   +2 more sources

Fish Collagen Peptides Protect against Cisplatin-Induced Cytotoxicity and Oxidative Injury by Inhibiting MAPK Signaling Pathways in Mouse Thymic Epithelial Cells

Marine Drugs, 2022
Thymic epithelial cells (TECs) account for the most abundant and dominant stromal component of the thymus, where T cells mature. Oxidative- or cytotoxic-stress associated injury in TECs, a significant and common problem in many clinical settings, may ...
Won Hoon Song, Hye-Yoon Kim, Ye Seon Lim, Seon Yeong Hwang, Changyong Lee, Do Young Lee, Yuseok Moon, Yong Jung Song, Sik Yoon   +8 more
doaj   +1 more source

Recent advances in poor HIV immune reconstitution: what will the future look like?

Frontiers in Microbiology, 2023
Combination antiretroviral therapy has demonstrated proved effectiveness in suppressing viral replication and significantly recovering CD4+ T cell count in HIV type-1 (HIV-1)-infected patients, contributing to a dramatic reduction in AIDS morbidity and ...
Wenyuan Zhang, Lianguo Ruan
doaj   +1 more source

Fish Collagen Peptides Enhance Thymopoietic Gene Expression, Cell Proliferation, Thymocyte Adherence, and Cytoprotection in Thymic Epithelial Cells via Activation of the Nuclear Factor-κB Pathway, Leading to Thymus Regeneration after Cyclophosphamide-Induced Injury

Marine Drugs, 2023
Prolonged thymic involution results in decreased thymopoiesis and thymic output, leading to peripheral T-cell deficiency. Since the thymic-dependent pathway is the only means of generating fully mature T cells, the identification of strategies to enhance
Do Young Lee, Won Hoon Song, Ye Seon Lim, Changyong Lee, Lata Rajbongshi, Seon Yeong Hwang, Byoung Soo Kim, Dongjun Lee, Yong Jung Song, Hwi-Gon Kim, Sik Yoon   +10 more
doaj   +1 more source

Identifying risk factors of immune reconstitution inflammatory syndrome in AIDS patients receiving highly active anti-retroviral therapy

Brazilian Journal of Infectious Diseases, 2013
Immune reconstitution inflammation syndrome typically occurs within days after patients undergo highly active anti-retroviral therapy and is a big hurdle for effective treatment of AIDS patients.
Bo He, Yuhuang Zheng, Meng Liu, Guoqiang Zhou, Xia Chen, Diallo Mamadou, Yan He, Huaying Zhou, Zi Chen   +8 more
doaj   +3 more sources

The role of pyroptosis in incomplete immune reconstitution among people living with HIV：Potential therapeutic targets

Pharmacological Research, 2023
Globally, HIV infection causes significant morbidity and mortality, and is a major public health problem. Despite the fact that widespread use of antiretroviral therapy (ART) has substantially altered the natural history of HIV infection from originally ...
Chao Xia, Xue Zhang, Vijay Harypursat, Jing Ouyang, Yaokai Chen   +4 more
doaj   +1 more source

Is immunological recovery clinically relevant at 100 days after allogeneic transplantation? [PDF]

The Korean Journal of Internal Medicine, 2020
Background/Aims Immune reconstitution following allogeneic hematopoietic stem cell transplantation (HSCT) is affected by multiple variables during the transplantation.
Jin Park, Sung Hee Lim, Se Hyung Kim, Jina Yun, Chan Kyu Kim, Sang Cheol Lee, Jong Ho Won, Dae Sik Hong, Seong Kyu Park   +8 more
doaj   +1 more source

Comparison of immune reconstitution after allogeneic vs. autologous stem cell transplantation in 182 pediatric recipients

Pediatric Hematology Oncology Journal, 2017
Background: Hematopoietic stem cell transplantation (HSCT) is a life-saving procedure for children with a variety of malignant and non-malignant conditions. However, even if immune reconstitution after HSCT has been studied in extensively, until now data
V. Wiegering, M. Eyrich, B. Winkler, P.G. Schlegel   +3 more
doaj   +1 more source

Immune reconstitution after hematopoietic stem cell transplantation

Frontiers in Immunology, 2016
The reconstitution and the regaining of function of a healthy, transplanted immune system is of utmost importance for the recovery and long term survival of patients after HSCT.
Justyna Ogonek, Mateja Kralj Juric, Sakhila Ghimire, Pavankumar Varanasi, Ernst Holler, Hildegard Greinix, Eva Weissinger   +6 more
doaj   +1 more source

Subdividing ART patients and analyzing the medical burden by modeling of CD4 cell count

Journal of Family Medicine and Primary Care, 2023
Objective: To subdivide the antiretroviral therapy (ART) human immunodeficiency virus (HIV)/acquired immune deficiency syndrome (AIDS) patients by modeling the CD4 cell count variable, with an aim to reduce the medical burden from lifelong ART. Materials
Li Min, Wang Qunwei
doaj   +1 more source