Results 51 to 60 of about 2,306,505 (335)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

High incidence of cytomegalovirus infection after nonmyeloablative stem cell transplantation: potential role of Campath-1H in delaying immune reconstitution

, 2002
Nonmyeloablative conditioning is increasingly used for transplantation in a wide range of diseases, but little is known about its impact on the incidence of infections and immune reconstitution.
Mahendra, P, Marshall, T, O'Gorman, P, Osman, H., Chakraverty, R, Hale, G., Osman, H, Peggs, K., O'Gorman, P., Mahendra, Premini, Mackinnon, S, Fegan, Christopher, Chopra, Ravinder, Linch, DC, Goldstone, A.H., Chopra, R, Waldmann, H., Milligan, D.W., Chakrabarti, Suparno, Hale, G, Chakrabarti, S., Marshall, T., Chakrabarti, S, Peggs, K, Chakraverty, Ronjon, Chopra, R., Waldmann, H, Kottaridis, P.D., Craddock, C., Milligan, DW, Mackinnon, S., Chakraverty, R., Kottaridis, PD, Yong, K., Kottaridis, P, Milligan, Donald, Mahendra, P., Craddock, Charles; id_orcid, Craddock, C, Yong, K, Goldstone, AH, Waldmann, Herman, Fegan, CD, Fegan, C.D., Linch, D.C.   +44 more
core   +1 more source

Transforming growth factor-β signaling in thymic epithelial cells : its role in development, steady-state and immune reconstitution [PDF]

, 2010
The thymus constitutes the primary lymphoid organ responsible for the generation of naïve T cells. Its stromal compartment is composed of a scaffold of different subsets of epithelial cells that provide soluble and membrane-bound molecules essential for ...
Hauri-Hohl, Mathias Martin
core   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Sequential anti-cytomegalovirus response monitoring may allow prediction of cytomegalovirus reactivation after allogeneic stem cell transplantation

, 2012
Background: Reconstitution of cytomegalovirus-specific CD3+CD8+ T cells (CMV-CTLs) after allogeneic hematopoietic stem cell transplantation (HSCT) is necessary to bring cytomegalovirus (CMV) reactivation under control. However, the parameters determining
Matthias Eder (21135), Borchers, Sylvia, Benno Wölk, Sylvia Borchers, Arnold Ganser, Pabst, Brigitte, Mischak-Weissinger, Eva Maria, Michael Stadler, Elke Dammann, Andrea Jarisch, Lehrnbecher, Thomas, Arnold Ganser (4454), Eva M. Weissinger (111202), Meral Yildiz, Schneider, Gisbert, Matthias Eder, Peter Bader, Melanie Bremm (111153), Koehl, Ulrike, Thomas Klingebiel, Michael Stadler (111171), Ulrike Koehl, Hans Martin, Benno Wölk (111163), Stadler, Michael, Thomas Lehrnbecher, Sylvia Borchers (111150), Wölk, Benno, Hans Martin (111179), Meral Yildiz (111168), Dammann, Elke, Thomas Klingebiel (111191), Brigitte Pabst (111160), Bader, Peter, Eder, Matthias, Jarisch, Andrea, Brigitte Pabst, Gisbert Schneider, Elke Dammann (111158), Gisbert Schneider (17096), Ulrike Koehl (111209), Thomas Lehrnbecher (111156), Klingebiel, Thomas, Esser, Ruth, Eva M. Weissinger, Ruth Esser (111165), Ganser, Arnold, Yildiz, Meral, Melanie Bremm, Peter Bader (111174), Eva M Weissinger, Bremm, Melanie, Andrea Jarisch (111185), Ruth Esser, Weissinger, Eva M., Köhl, Ulrike, Martin, Hans   +56 more
core   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Demodicosis revealing an HIV infection

New Microbes and New Infections, 2019
We report an observation of facial and upper limb demodicosis, revealing a human immunodeficiency virus infection. After an initial improvement with metronidazole, worsening of skin lesions related to immune reconstitution inflammatory syndrome was ...
W. Hachfi, D. Slama, N. Ben Lasfar, K. Mnif, F. Bellazreg, A. Fathallah, A. Letaief   +6 more
doaj   +1 more source

A Severe Case of Molluscum Contagiosum Immune Reconstitution Inflammatory Syndrome in a Patient with Human Immunodeficiency Virus

European Journal of Case Reports in Internal Medicine, 2022
Paradoxical immune reconstitution inflammatory syndrome (IRIS) in human immunodeficiency virus (HIV)-positive patients initiating antiretroviral treatment (ART) is caused by restored immunity to specific antigens, resulting in worsening of a pre-existing
Nida Siddiqui, Brett Stephen Mansfield, Nine-Paula Olmesdahl, Peter Swart, Jeremy Nel   +4 more
doaj   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Incomplete Immune Recovery in HIV Infection: Mechanisms, Relevance for Clinical Care, and Possible Solutions

Clinical and Developmental Immunology, 2012
Treatment of HIV-infected patients with highly active antiretroviral therapy (HAART) usually results in diminished viral replication, increasing CD4+ cell counts, a reversal of most immunological disturbances, and a reduction in risk of morbidity and ...
Julie C. Gaardbo, Hans J. Hartling, Jan Gerstoft, Susanne D. Nielsen   +3 more
doaj   +1 more source