Results 61 to 70 of about 128,938 (315)

Inositol phosphatase SHIP1 is a primary target of miR-155 [PDF]

, 2009
MicroRNA-155 (miR-155) has emerged as a critical regulator of immune cell development, function, and disease. However, the mechanistic basis for its impact on the hematopoietic system remains largely unresolved.
Baltimore, David, Chaudhuri, Aadel A., O'Connell, Ryan M., Rao, Dinesh S.   +3 more
core   +3 more sources

Reconstitution of CXCR3+ CCR6+ Th17.1‐Like T Cells in Response to Ofatumumab Therapy in Patients With Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Objectives Ofatumumab, a fully human anti‐CD20 monoclonal antibody, is effective in reducing relapses and disability progression in patients with multiple sclerosis. This study aimed to examine immune profile changes associated with ofatumumab in a prospective cohort of Chinese patients with relapsing–remitting multiple ...
Shu Yang, Tian‐Xiang Zhang, Jia Liu, Zhirui Liu, Lijie Zhu, Yan‐Yan Li, Bin Feng, Moli Fan, Fu‐Dong Shi, Chao Zhang   +9 more
wiley   +1 more source

Combining CD34+ stem cell selection with prophylactic pathogen and leukemia directed T‐cell immunotherapy to simultaneously reduce graft versus host disease, infection, and leukemia recurrence after allogeneic stem cell transplant

American Journal of Hematology, Volume 98, Issue 1, Page 159-165, January 2023., 2023
Donor stem cell product undergoes CD34 stem cell selection. CD34 positive stem cells are used for transplantation. Pathogen‐ and leukemia‐specific T‐cells are manufactured from CD34 negative fraction and infused prophylactically 21 days after transplant.
David J. Gottlieb, Gaurav Sutrave, Wei Jiang, Selmir Avdic, Janine A. Street, Renee Simms, Leighton E. Clancy, Vicki Antonenas, Brian S. Gloss, Caroline Bateman, David C. Bishop, Kenneth P. Micklethwaite, Emily Blyth   +12 more
wiley   +1 more source

Non-relativistic expansion of Dirac equation with spherical scalar and vector potentials by similarity renormalization group [PDF]

Phys. Rev. C 99, 054324 (2019), 2019
By following the conventional similarity renormalization group (SRG) expansion of the Dirac equation developed in [J.-Y. Guo, Phys. Rev. C \textbf{85}, 021302 (2012)], we work out the analytic expression of the ${1}/{M^4}$ order and verify the convergence of this method.
arxiv   +1 more source

Adoptive T Cell Therapy Following Haploidentical Hematopoietic Stem Cell Transplantation

Frontiers in Immunology, 2019
Delayed immune reconstitution and the consequently high rates of leukemia relapse and infectious complications are the main limitations of haploidentical hematopoietic stem cell transplantation.
Ping Zhang, Siok-Keen Tey, Siok-Keen Tey, Siok-Keen Tey   +3 more
doaj   +1 more source

Torque Teno Virus as a Potential Biomarker for Complications and Survival After Allogeneic Hematopoietic Stem Cell Transplantation

Frontiers in Immunology, 2020
Impaired immune reconstitution after allogeneic hematopoietic stem cell transplantation (HSCT) contributes to increased risk of cancer relapse and infection resulting in significant morbidity and mortality.
Amandine Pradier, Stavroula Masouridi-Levrat, Carine Bosshard, Carole Dantin, Diem-Lan Vu, Marie-Céline Zanella, Elsa Boely, Caroline Tapparel, Laurent Kaiser, Yves Chalandon, Federico Simonetta, Federico Simonetta, Eddy Roosnek   +12 more
doaj   +1 more source

Current knowledge of the immune reconstitution inflammatory syndrome in Whipple disease: a review

Frontiers in Immunology, 2023
Immune reconstitution inflammatory syndrome (IRIS) is characterized by exaggerated and dysregulated inflammatory responses that occur as a result of reconstitution of adaptive or innate immunity.
Xiangyi Song, Ruifeng Duan, Liwei Duan, Lijuan Wei   +3 more
doaj   +1 more source

Interleukin-7 deficiency in rheumatoid arthritis: consequences for therapy-induced lymphopenia [PDF]

, 2004
We previously demonstrated prolonged, profound CD4+ T-lymphopenia in rheumatoid arthritis (RA) patients following lymphocyte-depleting therapy. Poor reconstitution could result either from reduced de novo T-cell production through the thymus or from poor
Bingham, S.J., Brown, A.K., Buch, M., Douglas, S.H., Emery, P., Fearon, U., Field, S.L., Isaacs, J.D., Lawson, C.A., Ma, D., Maltby, S.L., Markham, A.F., Masurel, A., McGonagle, D., Moore, J., Morgan, A.W., Papadaki, H.A., Patel, P., Ponchel, F., Protheroe, A., Quinn, M., Short, K., Snowden, J., Straszynski, L., van Laar, J.M., Veale, D.J., Verburg, R.J.   +26 more
core   +2 more sources

Mesenchymal Stem Cells‐Derived Extracellular Vesicles Mimetics as Osteoinductive Mediators for Bone Healing

Advanced Functional Materials, EarlyView.
Mesenchymal stem cell‐derived nanoghosts (MSC‐NGs) mimic naturally secreted extracellular vesicles (MSC‐EVs) in structure and physicochemical properties but can be synthesized at more translatable yields. As osteogenic agents, MSC‐NGs demonstrate superior outcomes compared to MSC‐EVs.
Antoine Karoichan, Ling Li, Celine J. Agnes, Bettina M. Willie, Maryam Tabrizian   +4 more
wiley   +1 more source

Lovo‐cel gene therapy for sickle cell disease: Treatment process evolution and outcomes in the initial groups of the HGB‐206 study

American Journal of Hematology, Volume 98, Issue 1, Page 11-22, January 2023., 2023
Treatment process evolution. *The target TNC for BMH was ≥6 × 108/kg per patient. The Group B1 patient received lovo‐cel produced using both the original and refined manufacturing process, and the Group B2 patient received lovo‐cel produced using only the refined manufacturing process.
Julie Kanter, Alexis A. Thompson, Francis J. Pierciey Jr, Matthew Hsieh, Naoya Uchida, Philippe Leboulch, Manfred Schmidt, Melissa Bonner, Ruiting Guo, Alex Miller, Jean‐Antoine Ribeil, David Davidson, Mohammed Asmal, Mark C. Walters, John F. Tisdale   +14 more
wiley   +1 more source