Results 41 to 50 of about 44,461 (250)

Cellular and molecular insights into incomplete immune recovery in HIV/AIDS patients

Frontiers in Immunology, 2023
Highly active antiretroviral therapy (ART) can effectively inhibit virus replication and restore immune function in most people living with human immunodeficiency virus (HIV).
Liting Yan, Liting Yan, Kaiju Xu, Kaiju Xu, Qing Xiao, Lin Tuo, Lin Tuo, Tingting Luo, Tingting Luo, Shuqiang Wang, Shuqiang Wang, Renguo Yang, Renguo Yang, Fujie Zhang, Xingxiang Yang, Xingxiang Yang   +15 more
doaj   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Identifying risk factors of immune reconstitution inflammatory syndrome in AIDS patients receiving highly active anti-retroviral therapy

Brazilian Journal of Infectious Diseases, 2013
Immune reconstitution inflammation syndrome typically occurs within days after patients undergo highly active anti-retroviral therapy and is a big hurdle for effective treatment of AIDS patients.
Bo He, Yuhuang Zheng, Meng Liu, Guoqiang Zhou, Xia Chen, Diallo Mamadou, Yan He, Huaying Zhou, Zi Chen   +8 more
doaj  

Immune reconstitution inflammatory syndrome associated with acquired immunodeficiency syndrome-related gastrointestinal limited Kaposi's sarcoma presenting as acute intestinal obstruction: a case report

Journal of Medical Case Reports, 2011
Introduction Immune reconstitution inflammatory syndrome during anti-retroviral treatment of acquired immunodeficiency syndrome (AIDS) -associated gastrointestinal Kaposi's sarcoma has rarely been reported.
Pathak Hari, Shrivastav Ankit, Pal Jyotirmoy, Sarkar Dipendra   +3 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Tuberculosis/HIV Co-Infection: features of the immune response and management challenges

Каразінський імунологічний журнал
Background. Co-infection of tuberculosis and HIV is a global challenge exacerbated by the mutual influence of these diseases. HIV increases the risk of tuberculosis by 25–30 times, while tuberculosis accelerates HIV progression. According to WHO, 443,000
І.І. Hrek, O.S. Konstantynovska, V.B. Kushnir   +2 more
doaj   +1 more source

Baseline Naive CD4+ T-cell Level Predicting Immune Reconstitution in Treated HIV-infected Late Presenters

Chinese Medical Journal, 2016
Background: Among HIV-infected patients initiating antiretroviral therapy (ART), early changes in CD4+ T-cell subsets are well described. However, HIV-infected late presenters initiating treatment present with a suboptimal CD4+ T-cell reconstitution and ...
Fu-Ping Guo, Yi-Jia Li, Zhi-Feng Qiu, Wei Lv, Yang Han, Jing Xie, Yan-Ling Li, Xiao-Jing Song, Shan-Shan Du, Vikram Mehraj, Tai-Sheng Li, Jean-Pierre Routy   +11 more
doaj   +1 more source

Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy

FEBS Open Bio, EarlyView.
This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan, Ikram A. Burney, Shika Hanif Malgundkar, Siva Ramamoorthy, Ressin Varghese, Mohamed A. Al‐Kindi, Hamad Al Riyami, Shadia Al Bahlani, Sergey Dobretsov, Syed Imran Hassan, Benjamin K. Tsang, Yahya Tamimi   +11 more
wiley   +1 more source

Rapid CD4 decline prior to antiretroviral therapy predicts subsequent failure to reconstitute despite HIV viral suppression

Journal of Infection and Public Health, 2018
HIV-1 infection is characterized by loss of CD4 T cells, leading to immunodeficiency. Initiation of antiretroviral therapy (ART) results in suppression of the viral load and increased CD4 counts.
Majid Darraj, Leigh A. Shafer, Shanna Chan, Ken Kasper, Yoav Keynan   +4 more
doaj   +1 more source

Regulation of Gut Microbiota on Immune Reconstitution in Patients With Acquired Immunodeficiency Syndrome

Frontiers in Microbiology, 2020
Human immunodeficiency virus type 1 (HIV-1) infection of CD4+ T cells in the gut plays an insidious role in acquired immunodeficiency syndrome (AIDS) pathogenesis. Host immune function is closely related to gut microbiota.
Shi-Tao Geng, Shi-Tao Geng, Shi-Tao Geng, Zun-Yue Zhang, Zun-Yue Zhang, Yue-Xin Wang, Yue-Xin Wang, Yue-Xin Wang, Danfeng Lu, Danfeng Lu, Juehua Yu, Juehua Yu, Jian-Bo Zhang, Yi-Qun Kuang, Yi-Qun Kuang, Kun-Hua Wang, Kun-Hua Wang, Kun-Hua Wang   +17 more
doaj   +1 more source