Results 261 to 270 of about 292,750 (306)

Immunomics of Immune Rejection

2008
There is overwhelming evidence that the innate and adaptive arms of the human immune system can interact with autologous tumor cells and can, in rare circumstances, clear the host of cancer. Yet, most often tumor cells strike a favorable balance with the host’s immune response and continue their proliferation.
Ena Wang, Marianna Sabatino, Francesco M Marincola   +2 more
openaire   +1 more source

EFFECTIVE IMMUNE REJECTION OF ADVANCED METASTASIZED CANCER

International Journal of Oncology, 1995
A cellular cancer therapy is described with unique efficiency even in late-stage disease. in situ activated tumor-immune T cells, induced in allogeneic, tumor-resistant, MHC identical but superantigen different donor mice (B10.D2) could transfer strong graft-versus-leukemia (GvL) effects accompanied by only mild graft-versus-host (GvH) reactivity ...
V, Schirrmacher, P, Beckhove, A, Kruger, M, Rocha, V, Umansky, K, Fichtner, W, Hull, U, Zangemeisterwittke, A, Griesbach, K, Jurianz, P, Vonhoegen   +10 more
openaire   +2 more sources

Preventing Immune Rejection Through Gene Silencing

2010
Dendritic cells (DCs) comprise a family of professional antigen-presenting cells responsible for the induction of primary immune responses. DCs are also important for the induction of immunological tolerance. Recent research has revealed that DC maturation is associated with activation of the NF-kappaB pathway.
Xusheng, Zhang, Mu, Li, Wei-Ping, Min
openaire   +2 more sources

Immune Mechanisms of Corneal Allograft Rejection

Current Eye Research, 2007
Penetrating keratoplasty has been successfully performed on humans for over 100 years and remains the most common form of solid tissue transplantation. Although corneal allografts enjoy a remarkable degree of immune privilege, immune rejection remains the leading cause of keratoplasty failure.
openaire   +2 more sources

Immune mechanisms of acute and chronic rejection

Clinical Biochemistry, 2016
With the currently available immunosuppression, severe T-cell mediated rejection has become a rare event. With the introduction of modern antibody-detection techniques, such as the L-SAB technology, acute or hyperacute antibody-mediated rejection of the kidney are also seen infrequently. In contrast, chronic antibody-mediated rejection is considered to
Luis Eduardo, Becker, Christian, Morath, Caner, Suesal   +2 more
openaire   +2 more sources

Idiotypic immunization induces immunity to mutated p53 and tumor rejection

Nature Medicine, 1998
The p53 molecule might serve as a common tumor-associated antigen, as the tumor suppressor gene p53 is mutated and the p53 protein is often over-expressed in tumor cells. We report that effective immunity to p53 can be induced through an idiotypic network by immunization of mice with a monoclonal antibody (PAb-240) specific for mutated p53, or with a ...
P J, Ruiz, R, Wolkowicz, A, Waisman, D L, Hirschberg, P, Carmi, N, Erez, H, Garren, J, Herkel, M, Karpuj, L, Steinman, V, Rotter, I R, Cohen   +11 more
openaire   +2 more sources

Immunity and graft rejection in the ear

Immunology Today, 1984
Immunological activity in the ear and nose is often overlooked but can cause disease. Some examples were discussed at a recent conference*. Also considered was one of the most successful applications of tissue transplantation, middle ear reconstruction.
openaire   +2 more sources

Immune Tolerance and Rejection in Organ Transplantation

2019
In this chapter, we describe the history of transplantation, the multiple cell types, and mechanisms that are involved in rejection and tolerance of a transplanted organ, as well as summarize the common and promising new therapeutics used in transplant patients.
Jessica, Stolp, Masaaki, Zaitsu, Kathryn J, Wood   +2 more
openaire   +2 more sources

Xenotransplantation: Immune Barriers beyond Hyperacute Rejection

Clinical Science, 1997
1. The use of organs from animal donors (xenotransplantation) is a potential solution to the chronic shortage of allogeneic organs and currently the pig is thought to be the most suitable donor for man. However, porcine organs are rejected rapidly by a vascular process called hyperacute rejection which has so far prevented clinical xenotransplantation.
Anthony Dorling, Robert I. Lechler
openaire   +1 more source

Immune effector mechanisms in heart transplant rejection

Cardiovascular Research, 1994
It is well established that immunological mechanisms are responsible for the pathophysiology of several heart diseases, some contributing significantly to morbidity and mortality worldwide. Of the multiple cellular and humoral components participating in the overall immune response in heart diseases, this article mainly deals with cellular immunity ...
openaire   +2 more sources