Results 131 to 140 of about 1,447,984 (298)

Immunogenicity of Non-Living Anthrax Vaccine Candidates in Cattle and Protective Efficacy of Immune Sera in A/J Mouse Model Compared to the Sterne Live Spore Vaccine. [PDF]

Pathogens, 2020
Jauro S, Ndumnego OC, Ellis C, Buys A, Beyer W, Heerden HV.   +5 more
europepmc   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Assessing immune evasion potential and vaccine suitability of a feline panleukopenia virus strain

Veterinary Vaccine
Since the introduction of the feline panleukopenia virus (FPV) vaccine in China in 2011, it has played a crucial role in safeguarding the health of numerous pet cats by preventing FPV infections.
Jiakang Li, Yue Zeng, Jiajia Peng, Yongqi Zhou, Luying Li, Ying Wang, Zijun Ye, QingXiu Chen, Quanhui Yan, Qiuyan Li, Shengbo Cao, Dengyuan Zhou   +11 more
doaj   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Immune sera of M2e5x protein with AS04 confer heterosubtypic cross-protection against H1N1 and H5N1 viruses.

, 2015
Mice (n = 4) were intranasally infected with a lethal dose of influenza virus mixed with immune sera (1x) or naive sera (1x). Immune sera collected from vaccinated mice after 3rd immunization were incubated with influenza viruses, reassortants A/Vietnam ...
Cheol Kim (795749), Young-Tae Lee (467116), Hye Suk Hwang (467119), Sang-Moo Kang (329015), Jongsang Lee (795748), Yu-Na Lee (467124), Min-Chul Kim (329007)   +6 more
core   +1 more source

Evaluation of primate anti-pig xenoreactive immune responses using immortalized aortic endothelial cells from genetically modified pigs

Frontiers in Immunology
Porcine vascular endothelial cells are primary targets of humoral and cellular immune responses in pig-to-primate organ xenotransplantation. Although porcine aortic endothelial cells (PAECs) are widely used to evaluate primate anti-pig immune responses ...
Man Zhang, Man Zhang, Man Zhang, Man Zhang, Hao Feng, Hao Feng, Hao Feng, Hao Feng, Junlong Wu, Junlong Wu, Junlong Wu, Junlong Wu, Jie Lian, Mengting Chen, Yong Wang, Song Chen, Song Chen, Song Chen, Song Chen, Lan Zhu, Lan Zhu, Lan Zhu, Lan Zhu, Shaoping Deng, Shaoping Deng, Hong Wu, Jiaxiang Du, Jiaxiang Du, Dengke Pan, Dengke Pan, Dengke Pan, Gang Chen, Gang Chen, Gang Chen, Gang Chen   +34 more
doaj   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Comparison of motif-based and whole-unique-sequence-based analyses of phage display library datasets generated by biopanning of anti-Borrelia burgdorferi immune sera. [PDF]

PLoS One, 2020
Ionov Y, Rogovskyy AS.
europepmc   +1 more source