Results 111 to 120 of about 187,871 (305)
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Response of the tegument of Fasciola hepatica to infection and immunization sera in vitro
ParasitologyThe migratory phase is a critical time for Fasciola hepatica as it must locate, penetrate and migrate through the alimentary tract to the liver parenchyma whilst under attack from the host immune response.
Clive E. Bennett +3 more
doaj +1 more source
Flocculation reactions with hemolytic immune sera.
Experimental Biology and Medicine, 1924 As mentioned in the proceedings of the last meeting of this Society, the hemolytic action of the immune sera prepared by injection of alcoholic blood extracts is inhibited by the addition of these same extracts. In analogy to the Forssman heterogenetic antibodies (Sordelli and Pico, Sachs and Guth) these sera were found to give a very distinct ...
K. Landsteiner, J. V. D. Scheer
openaire +1 more source
Humoral immune parameters of cultured Atlantic halibut (Hippoglossus hippoglossus L.)
, 2001 Several humoral immune factors were studied in a group of cultured halibut (Hippoglossus hippoglossus L.). The serum protein and IgM concentration was comparable to levels seen in other teleost species.
Lange, S. +2 more
core +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Parasite, 2006 Sera from individuals suffering from leishmaniasis have been shown to strongly react against conserved proteins from the parasite, such as ribosomal, histones and heat-shock proteins.
Carmelo E. +3 more
doaj +1 more source
Characterization of antibodies purified from immune and control mouse sera.
, 2013 Total immunoglobulin pool was affinity purified from immune or control sera collected at the peak time point of neutralizing activity (figure 3B). The ELISA-binding (A) and NAb (B) activities were then measured as described in Figure 3 and showed that ...
Suganthi Suppiah (353571) +14 more
core +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
, 2009 Dengue viruses (DENV) are the etiological agents of dengue fever (DF) and dengue hemorrhagic fever (DHF). The DENV complex consists of four closely related viruses designated DENV serotypes 1 through 4.
Kraus, Annette A. +4 more
core +1 more source
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source