Results 111 to 120 of about 1,564,685 (307)

Assessment of infectivity and the impact on neutralizing activity of immune sera of the COVID-19 variant, CAL.20C. [PDF]

Signal Transduct Target Ther, 2021
Zhou Z, Du P, Yu M, Baptista-Hon DT, Miao M, Xiang AP, Lau JY, COVID-19 Immunity Investigation Group, Li G, Zhang K.   +9 more
europepmc   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Humoral immune parameters of cultured Atlantic halibut (Hippoglossus hippoglossus L.)

, 2001
Several humoral immune factors were studied in a group of cultured halibut (Hippoglossus hippoglossus L.). The serum protein and IgM concentration was comparable to levels seen in other teleost species.
Lange, S., Magnadóttir, B., Guđmundsdottir, B.K.   +2 more
core   +1 more source

Direct comparison of SARS-CoV-2 variant specific neutralizing antibodies in human and hamster sera

npj Vaccines
Antigenic characterization of newly emerging SARS-CoV-2 variants is important to assess their immune escape and judge the need for future vaccine updates.
Annika Rössler, Antonia Netzl, Ludwig Knabl, Samuel H. Wilks, Barbara Mühlemann, Sina Türeli, Anna Mykytyn, Dorothee von Laer, Bart L. Haagmans, Derek J. Smith, Janine Kimpel   +10 more
doaj   +1 more source

Reduced SARS-CoV-2 disease outcomes in Syrian hamsters receiving immune sera: Quantitative image analysis in pathologic assessments. [PDF]

Vet Pathol, 2022
Piedra-Mora C, Robinson SR, Tostanoski LH, Dayao DAE, Chandrashekar A, Bauer K, Wrijil L, Ducat S, Hayes T, Yu J, Bondzie EA, McMahan K, Sellers D, Giffin V, Hope D, Nampanya F, Mercado NB, Kar S, Andersen H, Tzipori S, Barouch DH, Martinot AJ.   +21 more
europepmc   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

PMN respiratory burst activity depends on merozoites and immune antibodies.

, 2013
ADRB indexes determined as described in Materials and Methods using a single pool of PMN: with immune (HIS) or non-immune (NIS) sera only (blue); with merozoites and immune (HIS, S2, S3, or S4) or non-immune (NIS, S5, S6) sera (green) or the same with ...
Antoine-Marie Diatta (366058), Hannah E. J. Polson (366056), Laurence Marrama (246603), Ronald Perraut (366061), Charlotte Joos (366055), Jean-François Trape (81719), Shirley Longacre (366060), Sandra Corre (366057), Babacar Diouf (366059), Adama Tall (81717)   +9 more
core   +1 more source

Response of the tegument of Fasciola hepatica to infection and immunization sera in vitro

Parasitology
The migratory phase is a critical time for Fasciola hepatica as it must locate, penetrate and migrate through the alimentary tract to the liver parenchyma whilst under attack from the host immune response.
Clive E. Bennett, Adam P.S. Bennett, Robert E.B. Hanna, Mark W. Robinson   +3 more
doaj   +1 more source

The SARS-CoV-2 spike L452R-E484Q variant in the Indian B.1.617 strain showed significant reduction in the neutralization activity of immune sera. [PDF]

Precis Clin Med, 2021
Li G, Zhou Z, Du P, Yu M, Li N, Xiong X, Huang H, Liu Z, Dai Q, Zhu J, Guo C, Wu S, Baptista-Hon DT, Miao M, Ming LW, Wu Y, Zeng F, Zhang CL, Zhang ED, Song H, Liu J, Lau JY, Xiang AP, Zhang K.   +23 more
europepmc   +1 more source

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source