Results 91 to 100 of about 289,221 (311)

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Flocculation reactions with hemolytic immune sera.

Experimental Biology and Medicine, 1924
As mentioned in the proceedings of the last meeting of this Society, the hemolytic action of the immune sera prepared by injection of alcoholic blood extracts is inhibited by the addition of these same extracts. In analogy to the Forssman heterogenetic antibodies (Sordelli and Pico, Sachs and Guth) these sera were found to give a very distinct ...
K. Landsteiner, J. V. D. Scheer
openaire   +1 more source

Novel screening methods for the detection of Yersinia enterocolitica in infected blood used for transfusion : a thesis presented in partial fulfilment of the requirements for the degree of Master of Science in Microbiology at Massey University [PDF]

, 2000
Between 1991-1996, 8 patients experienced rare life-threatening reactions that followed the transfusion of blood infected with Yersinia enterocolitica.
Kendrick, Christopher John
core  

Detection of antibodies to Sendai virus by enzyme-linked immunosorbent assay (ELISA) [PDF]

, 1979
An enzyme-linked immunosorbent assay (ELISA) for the detection of antibodies to Sendai virus, a paramyxovirus, is described. The assay was found to be about 20-fold more sensitive than the hemagglutination inhibition assay.
Avrameas, Bennink, Doherty, Doherty, Ertl, Gerhard, Hunter, Koszinowski, Koszinowski, Koszinowski, Leinikki, Lowry, Nakane, Ornstein, Roberts, Salk, Svenag, White   +17 more
core   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Cancer biomarkers, and novel techniques for detection [PDF]

, 2017
Technologies for early detection of tumors is critical for better therapy outcome and overall change in cancer survival. These assays must be capable of detecting tumors at early stages in order to prevent metastasis of the tumor and help reduce ...
Jamal, Tameem
core  

Immune-Complex Mimics as a Molecular Platform for Adjuvant-Free Vaccine Delivery [PDF]

, 2013
Protein-based vaccine development faces the difficult challenge of finding robust yet non-toxic adjuvants suitable for humans. Here, using a molecular engineering approach, we have developed a molecular platform for generating self-adjuvanting immunogens
A Demissie, A Raja, A Regnault, A Williams, AF Cunningham, AN Antoniou, AR Berengian, AS Mustafa, B Heyman, BC Schalke, CK Kennaway, Craig van Dolleweerd, CT Cady, D Chargelegue, D Matheoud, DH Schuurhuis, E Celis, E Celis, EJ Wiersma, Elena Stylianou, EM Leyten, F Manca, F Pinheiro da Silva, F Villinger, F Winau, G Falero-Diaz, G Terres, GG Klaus, Gil Reynolds Diogo, H Boesen, Ilaria Pepponi, J Laissue, JM den Haan, Julian K.-C. Ma, K Osato, KB Reid, M Jacobsen, Matthew J. Paul, MF Bachmann, N Caccamo, N Polyanskaya, P Andersen, Pascal M. W. Drake, PD Simitsek, Pere-Joan Cardona, PM Guyre, PM Hogarth, PS Jackett, Q Li, R Jemmerson, R Pal, R Reljic, R Reljic, Rajko Reljic, RG Taylor, RJ Eisenberg, RJ Wilkinson, S Marusic-Galesic, SA Moreno-Mendieta, SA Plotkin, U Abdel-Motal, V Roupie, W Phoolcharoen, WE Houston, WR Heath, Y Yuan, Y Yuan, YM Wen, Z Chang   +68 more
core   +2 more sources

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Immunoreactive proteins of Bifidobacterium longum ssp. longum CCM 7952 and Bifidobacterium longum ssp. longum CCDM 372 identified by gnotobiotic mono-colonized mice sera, immune rabbit sera and nonimmune human sera.

Frontiers in Microbiology, 2016
The Bifidobacteria show great diversity in the cell surface architecture which may influence the physicochemical properties of the bacterial cell and strain specific properties.
Sabina Górska, Ewa Dylus, Angelika Rudawska, Ewa Brzozowska, Dagmar Srutkova, Martin Schwarzer, Agnieszka Razim, Hana Kozakova, Andrzej Gamian   +8 more
doaj   +1 more source