Results 91 to 100 of about 1,564,685 (307)

Potency and breadth of human primary ZIKV immune sera shows that Zika viruses cluster antigenically as a single serotype - Table 3

, 2020
Potency and breadth of human primary ZIKV immune sera shows that Zika viruses cluster antigenically as a single serotype - Table
Jonathan Salberg (8704146), William B. Messer (8704161), Bettie W. Kareko (8704152), Chad D. Nix (8704143), Brian L. Booty (8704158), Zoe L. Lyski (8704155), Felicity J. Coulter (8704149)   +6 more
core   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Immunoreactive proteins of Bifidobacterium longum ssp. longum CCM 7952 and Bifidobacterium longum ssp. longum CCDM 372 identified by gnotobiotic mono-colonized mice sera, immune rabbit sera and nonimmune human sera.

Frontiers in Microbiology, 2016
The Bifidobacteria show great diversity in the cell surface architecture which may influence the physicochemical properties of the bacterial cell and strain specific properties.
Sabina Górska, Ewa Dylus, Angelika Rudawska, Ewa Brzozowska, Dagmar Srutkova, Martin Schwarzer, Agnieszka Razim, Hana Kozakova, Andrzej Gamian   +8 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Removal of cross-reactive antibodies from primary DENV3-immune sera significantly protects AG129 mice from ADE-induced mortality.

, 2014
Primary DENV3-immune human sera (DT118 and DT105) were depleted with heterotypic DENV2 virus (resulting in depletion of heterotypic anti-DENV1, DENV2 and DENV4 antibodies), transferred to AG129 mice 24 hours prior to administration of 2×105 pfu DENV2 ...
Eva Harris (27355), Ruklanthi de Alwis (216870), Katherine L. Williams (197272), Chih-Yun Lai (108062), James E. Crowe (638220), Wei-Kung Wang (108070), Aravinda M. de Silva (180486), Bhumi Patel (173812), Scott A. Smith (638219), Michael A. Schmid (638218)   +9 more
core   +1 more source

Binding to RBM peptide by mouse immune sera and human neutralizing monoclonal antibodies.

, 2022
A. Binding of serial serum dilutions of immune sera of the day 30 and 45 bleeds on 96-well microtiter plates coated with RBM synthetic peptide 475AGSTPCNGVEGFNCYFPLQSYGFQPT500. B. Binding of HRP-labeled B38 (top) and CC12.1 (bottom) to RBM peptide or RBD
Gonzalo Almanza (246998), Aaron F. Carlin (6167324), Eduardo Olmedillas (3110748), Alex E. Clark (10130709), Erica Ollmann Saphire (10099368), Maurizio Zanetti (112276), Yan Wu (70890), William Bray (11486383), Valentina Kouznetsova (315936), Andrea Castro (7043942), Sandra L. Leibel (5792234), George F. Gao (30860), Igor F. Tsigelny (270708)   +12 more
core   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Serological tests based on viral glycoproteins for detecting neutralizing antibodies to measles, mumps and rubella viruses

Вопросы вирусологии
Introduction. Measles, mumps and rubella viruses are highly contagious viruses that can cause serious clinical outcomes, complications and death.
Firaya G. Nagieva, Elena P. Barkova, Olga S. Kharchenko, Alexander V. Sidorov, Natalia N. Vlasova, Olga A. Trubacheva, Yulia N. Tarakanova, Vladislav V. Semerikov, Alfiya K. Tagirova, Dinora A. Yakovleva, Evgeny A. Pashkov, Ekaterina S. Osipova, Anastasiya M. Polisadova, Oksana A. Svitich, Vitaly V. Zverev   +14 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source