Results 71 to 80 of about 187,871 (305)
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Novel proteins of Plasmodium falciparum identified by differential immunoscreening using immune and patient sera [PDF]
, 1994 A differential serological screen of a λgt11 cDNA expression library of Plasmodium falciparum was performed in an attempt to identify novel and putative host-protective antigens of the parasite.
Kar, S. K. +4 more
core +1 more source
Effects of clodronate-liposomes on protective efficacy against 2009 H1N1 virus by M2 immune sera.
, 2013 (A) A representative flow cytometry profile of DC and macrophage cell gates. Naive mice were intranasally treated with PBS (i) or clodronate-liposome (ii), and DC cells (CD11b+CD11c+) and macrophage cells (CD11b+CD11c−) in lungs were analyzed by flow ...
Kyoung-Mi Park (329009) +9 more
core +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Protective efficacy against influenza A H3N2 virus of M2 VLP immune sera.
, 2013 Immune sera collected from M2 VLP vaccinated mice at 4 weeks after boost vaccination were incubated with a lethal dose of A/Philippines/82 (H3N2) influenza virus at room temperature for 30 min.
Kyoung-Mi Park (329009) +9 more
core +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Immune complexes in blood serum of calves with clinical symptoms of bronchopneumonia [PDF]
Veterinarski Glasnik, 2011 Pneumonia in preruminant calves is a multifactorial disease. Infectious agents, the environment, management and the immune status of the calves are all important factors in determining the outcome of an infection.
Fratrić Natalija +4 more
doaj +1 more source
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Analysis of B. burgdorferi-specific immune sera by immunoblotting.
, 2013 The whole-cell lysates of B. burgdorferi WT, sVlsE, and ΔVlsE clones (106 cells/lane) were treated with anti-WT, anti-sVlsE, or anti-ΔVlsE (panel A, B, and C, respectively) immune sera collected from C3H mice at day 28 post infection.
Troy Bankhead (70620) +1 more
core +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source