Results 141 to 150 of about 2,089,667 (358)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Role of immune and metabolic processes in pathogenesis of the development of chronic periodontitis and pneumonia and correction of their impairment with quercetin

Journal of Education, Health and Sport, 2017
Chronic periodontitis is one of the most common diseases in dental practice, which shows annual tendency to increase. Nowadays, mechanisms of the formation of this pathology have been substantially studied.
O. O. Chuhai, M. S. Reheda, S. M. Reheda
doaj  

Towards a Point-of-Care Test of CD4⁺ T Lymphocyte Concentrations for Immune Status Monitoring with Magnetic Flow Cytometry

Micromachines
For the treatment of human immunodeficiency virus (HIV)-infected patients, the regular assessment of the immune status is indispensable. The quantification of CD4+ T lymphocytes in blood by gold standard optical flow cytometry is not point-of-care ...
Moritz Leuthner, Mathias Reisbeck, Michael Helou, Oliver Hayden   +3 more
doaj   +1 more source

Immune functions, clinical parameters and hormone receptor status in breast cancer patients

, 1999
Lalita A. Shevde, Narendra Joshi, Sanjay B. Dudhat, Rohini Hawaldar, Jayshree J. Nadkarni   +4 more
openalex   +2 more sources

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Cow serum and colostrum immunoglobulin (IgG1) concentration of five suckler cow breed types and subsequent immune status of their calves [PDF]

, 2004
peer-reviewedB. Murphy would like to gratefully acknowledge receipt of a Walsh Fellowship provided by Teagasc.The objective of this study was to determine the effect of cow breed type on (a) cow serum and colostrum immunoglobulin (IgG1) concentrations
Drennan, Michael J, Earley, Bernadette, Murphy, B.M., O'Mara, Frank P.   +3 more
core  

Editorial to the Special Issue “Homeostasis: Metals and Cellular Redox and Immunity Status” [PDF]

, 2023
Bernhard Michalke, Vivek Venkataramani
openalex   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

PECULIARITIES OF THE IMMUNE STATUS AND CLINICAL FEATURES OF IMMUNODEFICIENCY IN PATIENTS WITH VENTRAL HERNIA

, 2014
E. N. Kologrivova, M. S. Deryugina, S. O. Romanova, V. S. Muravjova   +3 more
openalex   +2 more sources

Lack of association between Rh status, Rh immune globulin in pregnancy and autism [PDF]

, 2007
Judith H. Miles, Tomoo Takahashi
openalex   +1 more source