Results 1 to 10 of about 320,196 (265)
SIGNATURE: A workbench for gene expression signature analysis [PDF]
BMC Bioinformatics, 2011 Background The biological phenotype of a cell, such as a characteristic visual image or behavior, reflects activities derived from the expression of collections of genes.
Chang Jeffrey T +5 more
doaj +3 more sources
EBioMedicine, 2018 Background: Hypoxia is associated with a poor prognosis in prostate cancer. This work aimed to derive and validate a hypoxia-related mRNA signature for localized prostate cancer.
Lingjian Yang +27 more
doaj +3 more sources
A Novel Ferroptosis-Associated Gene Signature to Predict Prognosis in Patients with Uveal Melanoma
Diagnostics, 2021 Background: Uveal melanoma (UM) is the most common intraocular tumor in adults. Ferroptosis is a newly recognized process of cell death, which is different from other forms of cell death in terms of morphology, biochemistry and genetics, and has played a
Huan Luo, Chao Ma
doaj +3 more sources
Construction and validation of a novel gene signature for predicting the prognosis of osteosarcoma
Scientific Reports, 2022 Osteosarcoma (OS) is the most common type of primary malignant bone tumor. The high-throughput sequencing technology has shown potential abilities to illuminate the pathogenic genes in OS.
Jinpo Yang +3 more
doaj +1 more source
Comprehensive analysis reveals a metabolic ten-gene signature in hepatocellular carcinoma [PDF]
PeerJ, 2020 Background Due to the complicated molecular and cellular heterogeneity in hepatocellular carcinoma (HCC), the morbidity and mortality still remains high level in the world.
Zhipeng Zhu +6 more
doaj +2 more sources
Frontiers in Immunology, 2021 Helicobacter pylori is a gram-negative bacterium that colonizes the human gastric mucosa and can lead to gastric inflammation, ulcers, and stomach cancer. Due to the increase in H.
Mohamed Tarek Badr +4 more
doaj +1 more source
Signature Genes as a Phylogenomic Tool [PDF]
Molecular Biology and Evolution, 2008 Gene content has been shown to contain a strong phylogenetic signal, yet its usage for phylogenetic questions is hampered by horizontal gene transfer and parallel gene loss and until now required completely sequenced genomes. Here, we introduce an approach that allows the phylogenetic signal in gene content to be applied to any set of sequences, using ...
Dutilh, B.E. +3 more
openaire +5 more sources
Association between a Prognostic Gene Signature and Functional Gene Sets
Bioinformatics and Biology Insights, 2008 Background The development of expression-based gene signatures for predicting prognosis or class membership is a popular and challenging task. Besides their stringent validation, signatures need a functional interpretation and must be placed in a ...
Manuela Hummel +4 more
doaj +2 more sources
CoMI: consensus mutual information for tissue-specific gene signatures
BMC Bioinformatics, 2022 Background The gene signatures have been considered as a promising early diagnosis and prognostic analysis to identify disease subtypes and to determine subsequent treatments.
Sing-Han Huang +5 more
doaj +1 more source
Pharmaceuticals, 2022 Aberrant expression of genes contributes to the chemoresistance of colorectal cancer (CRC) treatment. This study aimed to identify genes associated with the chemoresistance of oxaliplatin-based chemotherapy in CRC patients and to construct a signature ...
Yixin Yin +5 more
doaj +1 more source